Multicentric clinical and epidemiological comparison of neuromyelitis optica spectrum disorder with multiple sclerosis from India

Gupta, Salil; Rehani, Varun; Acharya, Ritesh; Purohit, Pritam; Anadure, Ravi; Ahmad, Faiz; Soni, Rahul; Gupta, Anirban Sen; Hiremath, Ravi

doi:10.1016/j.msard.2020.102616

Cited by 5 publications

(7 citation statements)

References 18 publications

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“…Part of the data of this project has already been published. [ 8 ] However, the data analysed as a part of the current study has neither been presented nor been published earlier.…”

Section: Ethodsmentioning

confidence: 99%

A Comparative Analysis of Clinical and Imaging Features of Aquaporin 4 (AQP4) Antibody Positive, Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Positive and Double Seronegative Subtypes of Neuro Myelitis Optica Spectrum Disorder (NMOSD)

Gupta¹,

Rehani²,

Dhull³

et al. 2022

Annals of Indian Academy of Neurology

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Objectives: Study was conducted with aim of comparing subtypes types of NMOSD based on serology. Methods: In this retrospective study, patients ≥18 years were included satisfying IPND 2015 criteria. Three groups were created based on seropositivity for AQP4 antibody, MOG antibody or double seronegative. Demographic, clinical and imaging were compared using regression analysis. Results: Forty-six patients, 28 (60.9%) AQP4+, 11 (23.9%) MOG + and remaining 7 (15.2%) double seronegative were included. Thirty-seven patients (80.4%) had presenting symptoms localized to optic nerve and/or cord [AQP4 + 22 (78.5%), MOG + 9 (81.8%) and double seronegative 6 (85.7%)]. Presentation with bilateral optic neuritis was more common in AQP4- patients. Twenty (86.8%) out of the 23 patients who had relapsing disease localized to optic nerve and/or spinal cord [AQP4 + 13/14 (92.8%), MOG + 3/5 (60%) and double seronegative 4/4 (100%)]. Relapses were more common in AQP4+ (77% vs 12% vs10%). In AQP4 negative group disability (EDSS 4.2 vs 3.3) and progression index was relatively less (1.6 vs 1.1). CSF pleocytosis (38.8% vs 17.9%) and raised proteins (66.6% vs 32.1%) were also more common. Optic nerve MRI (>50% optic nerve and chiasma involvement) was more commonly abnormal in AQP4 negative (52.9% vs 31.2%). Regression analysis revealed females to be significantly higher in AQP4 positive NMOSD (89.3%) when compared to MOG positive (36.4%) and double seronegative (42.9%). Conclusion: Gender was the only significant difference between the three groups. There was trend towards greater disability and more relapses in AQP4 + groups.

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“…Part of the data of this project has already been published. [ 8 ] However, the data analysed as a part of the current study has neither been presented nor been published earlier.…”

Section: Ethodsmentioning

confidence: 99%

A Comparative Analysis of Clinical and Imaging Features of Aquaporin 4 (AQP4) Antibody Positive, Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Positive and Double Seronegative Subtypes of Neuro Myelitis Optica Spectrum Disorder (NMOSD)

Gupta¹,

Rehani²,

Dhull³

et al. 2022

Annals of Indian Academy of Neurology

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“…With the recent availability of commercial diagnostic kits (Euroimmun, Germany) for detection of AQP4‐IgG & MOG‐IgG, several papers have been published with definitive diagnosis of seropositive NMOSD from different parts of India. These included studies which described clinical features of AQP4‐IgG‐positive 39,40,45,46 and MOG‐IgG‐positive patients, 43,44,49,51 studies highlighting seroprevalence among patients with atypical demyelinating disorders 42 and comparative studies of demyelinating disorders from different regions of India 48,50 . Pediatric demyelinating disorders have been described from hospital settings 41,47 .…”

Section: Resultsmentioning

confidence: 99%

“…Between 1999 and 2019, search results produced 99 articles related to “Neuromyelitis optica spectrum disorders”, “NMOSD”, “NMO”, “AQP4‐IgG”, “MOG‐IgG” AND India. After excluding reviews and case reports, 13 articles that described clinical, demographic features, investigations including testing for AQP4‐IgG and MOG‐IgG were included 39‐51 . These are listed chronologically in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…After excluding reviews and case reports, 13 articles that described clinical, demographic features, investigations including testing for AQP4-IgG and MOG-IgG were included. [39][40][41][42][43][44][45][46][47][48][49][50][51] These are listed chronologically in Table 2.…”

Section: Demographic and Clinical Features Of Nmosd In Indiamentioning

confidence: 99%

“…These included studies which described clinical features of AQP4-IgG-positive 39,40,45,46 and MOG-IgG-positive patients, 43,44,49,51 studies highlighting seroprevalence among patients with atypical demyelinating disorders 42 and comparative studies of demyelinating disorders from different regions of India. 48,50 Pediatric demyelinating disorders have been described from hospital settings. 41,47 Among AQP4-IgG-positive patients, there was overwhelming female preponderance and onset of disease in the second decade of life.…”

Section: Demographic and Clinical Features Of Nmosd In Indiamentioning

confidence: 99%

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Epidemiology and clinical features of demyelinating disorders in India

Pandit

Mustafa

2021

Neurology & Clinical Neurosc

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In tropical countries like India, noncommunicable diseases have traditionally received less priority over infectious diseases. In recent times, however, demyelinating disorders of the central nervous system have become recognized as an important group of noncommunicable neurological disorders in India. It is possible that increasing awareness among doctors on one hand and availability of magnetic resonance imaging facilities (MRI) in teaching and private hospitals in the metropolitan cities of India on the other have contributed to early diagnosis and treatment.The study of demyelinating disorders of the nervous system in India has been limited by many factors. Kurtzke's 1 epidemiological studies pointed to India as having a low prevalence for multiple sclerosis (MS). Neuromyelitis optica (NMO) was considered a variant of MS. In the pre-MRI era, diagnosis of MS centered around clinical

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Comparisons of clinical phenotype, radiological and laboratory features, and therapy of neuromyelitis optica spectrum disorder by regions: update and challenges

Liu

Shi

Zhu

et al. 2022

Autoimmunity Reviews

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Multicentric clinical and epidemiological comparison of neuromyelitis optica spectrum disorder with multiple sclerosis from India

Cited by 5 publications

References 18 publications

A Comparative Analysis of Clinical and Imaging Features of Aquaporin 4 (AQP4) Antibody Positive, Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Positive and Double Seronegative Subtypes of Neuro Myelitis Optica Spectrum Disorder (NMOSD)

A Comparative Analysis of Clinical and Imaging Features of Aquaporin 4 (AQP4) Antibody Positive, Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Positive and Double Seronegative Subtypes of Neuro Myelitis Optica Spectrum Disorder (NMOSD)

Epidemiology and clinical features of demyelinating disorders in India

Comparisons of clinical phenotype, radiological and laboratory features, and therapy of neuromyelitis optica spectrum disorder by regions: update and challenges

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