Multicentric Granular Cell Tumors With Heart Involvement: A Case Report

Malignant granular cell tumour at the interventricular septum

“…Distant metastasis is reported in half of the cases, and local recurrence is usual [ 1 ]. Only a few GCT cases demonstrate cardiac involvement, mostly observed in the ventricular myocardium, and the patients are asymptomatic [ 3 ]. However, some patients with conduction system involvement, for example, the sinoatrial node, may present with sudden death [ 4 ].…”

Vascular invasion and other invasive features in granular cell tumours of the skin: a multicentre study of 119 cases

“…The granular cells can also involve or replace the musculature, growing along muscle fibres or extending within the sarcolemmal sheath in striated muscle 2. Granular cell tumours have also been described in smooth muscle tissue, in heart muscle, or in fibrous tissue such as tendons, fascia or ligaments 2 7…”

18F-FDG PET/CT and MRI of a Mediastinal Malignant Granular Cell Tumor With Associated Recurrent Pericarditis

“…[1][2][3] Granular cell tumors usually present as (sub)cutaneous nodules but nearly any organ can be involved. [3][4][5][6][7][8] The role of 18 F-FDG PET/CT in granular cell tumors has been reported in few case studies, and the majority of malignant subtypes had a higher FDG avidity compared with benign subtypes. [6][7][8] Therefore, 18 F-FDG PET/CT may play an important role not only to assess the disease extent, but assessing the metabolic activity may be of interest to differentiate between benign and malignant lesions, but warrants further investigation.…”