Multichannel Wireless Neurosensing System for battery-free monitoring of neuronal activity

Moncion, Carolina; Balachandar, Lakshmini; Venkatakrishnan, Satheesh Bojja; Volakis, John L.; Riera, Jorge J.

doi:10.1016/j.bios.2022.114455

Cited by 3 publications

(3 citation statements)

References 32 publications

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“…To record neuronal activity from different brain layers, it is possible to detect individual layers by multiple electrodes and connect all electrodes to the same Voltage Sensing Resonator via a multiplexer [76][77][78] . As a result, the same detector can consecutively encode neuronal voltages from multiple electrodes while continuously encoding MRI signals from the same field-of-view.…”

Section: Discussionmentioning

confidence: 99%

A novel hybrid Wireless Integrated Sensing Detector for simultaneous EEG and MRI (WISDEM)

Chen,

Qian,

Razansky

et al. 2024

Preprint

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Concurrent recording of EEG/fMRI signals reveals cross-scale neurovascular dynamics that are crucial for elucidating fundamental linkage between function and behaviors. However, MRI scanners generate tremendous artifacts for EEG detection. Despite existing denoising methods, cabled connections to EEG receivers are susceptible to environmental fluctuations inside MRI scanners, creating baseline drifts that complicate EEG signal retrieval from the noisy background. Here, a Wireless Integrated Sensing Detector for simultaneous EEG and MRI (WISDEM) is developed to encode fMRI and EEG signals on distinct sidebands of the detector oscillation carrier wave for detection by a standard MRI console over the entire duration of fMRI sequence. Local field potential (LFP) and fMRI maps are retrieved through low-pass and high-pass filtering of frequency-demodulate signals. From optogenetically-stimulated somatosensory cortex, the positive correlation between evoked LFP and fMRI signals validates strong neurovascular coupling, enabling cross-scale brain mapping with this 2-in-1 transducer as a research and diagnostic tool.

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Section: Discussionmentioning

confidence: 99%

A novel hybrid Wireless Integrated Sensing Detector for simultaneous EEG and MRI (WISDEM)

Chen,

Qian,

Razansky

et al. 2024

Preprint

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“…Fully implantable, battery-free brain recording devices (Figure a) have emerged as a promising technology for chronic monitoring of neural activity in the brain. This field has been rapidly evolving over the past decade, as shown in Figure b, ,,− with demonstrations rapidly increasing after the enactment of the brain initiative and associated international counterparts. Wireless power supply enables advanced sensing modalities to facilitate high sampling rate and continuous monitoring of neural dynamics over long periods of time without subject interaction.…”

Section: Organ Interfacesmentioning

confidence: 99%

Wireless Battery-free and Fully Implantable Organ Interfaces

Bhatia,

Hanna,

Stuart

et al. 2024

Chem. Rev.

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Advances in soft materials, miniaturized electronics, sensors, stimulators, radios, and battery-free power supplies are resulting in a new generation of fully implantable organ interfaces that leverage volumetric reduction and soft mechanics by eliminating electrochemical power storage. This device class offers the ability to provide high-fidelity readouts of physiological processes, enables stimulation, and allows control over organs to realize new therapeutic and diagnostic paradigms. Driven by seamless integration with connected infrastructure, these devices enable personalized digital medicine. Key to advances are carefully designed material, electrophysical, electrochemical, and electromagnetic systems that form implantables with mechanical properties closely matched to the target organ to deliver functionality that supports high-fidelity sensors and stimulators. The elimination of electrochemical power supplies enables control over device operation, anywhere from acute, to lifetimes matching the target subject with physical dimensions that supports imperceptible operation. This review provides a comprehensive overview of the basic building blocks of battery-free organ interfaces and related topics such as implantation, delivery, sterilization, and user acceptance. State of the art examples categorized by organ system and an outlook of interconnection and advanced strategies for computation leveraging the consistent power influx to elevate functionality of this device class over current battery-powered strategies is highlighted.

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“…Before stimulation, sites were shaved and cleaned with disinfectant. A similar approach to previous studies was taken in the gathering and processing of SSEP data (Hosp et al 2008, Moncion et al 2022. Constant current pulses (1Hz, 0.5 mA, 2 ms duration) were delivered via bipolar needle electrodes to the median and tibialis nerves (A-M Systems, Sequim, WA, USA).…”

Section: Recording Of Somatosensory Evoked Potentialsmentioning

confidence: 99%

Development of a novel, concentric micro-ECoG array enabling simultaneous detection of a single location by multiple electrode sizes

Akamine,

Garich,

Gulick

et al. 2024

Biomed. Phys. Eng. Express

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Objective. Detection of the epileptogenic zone is critical, especially for patients withdrug-resistant epilepsy. Accurately mapping cortical regions exhibiting high activity duringspontaneous seizure events while detecting neural activity up to 500 Hz can assist clinicians’surgical decisions and improve patient outcomes. Approach. We designed, fabricated,and tested a novel hybrid, multi-scale micro-electrocorticography (micro-ECoG) array witha unique embedded configuration. This array was compared to a commercially availablemicroelectrode array (Neuronexus) for recording neural activity in rodent sensory cortexelicited by somatosensory evoked potentials and pilocarpine-induced seizures. Main resultsEvoked potentials and spatial maps recorded by the multi-scale array (“micros”, “mesos”, and“macros” refering to the relative electrode sizes, 40 micron, 1 mm, and 4 mm respectively)were comparable to the Neuronexus array. The SSEPs recorded with the micros had higherpeak amplitudes and greater signal power than those recorded by the larger mesos and macro.Seizure onset events and high-frequency oscillations (∼450 Hz) were detected on the multi-scale, similar to the commercially available array. The micros had greater SNR than the mesosand macro over the 5-1000 Hz frequency range during seizure monitoring. During corticalstimulation experimentation, the mesos successfully elicited motor effects. Significance.Previous studies have compared macro- and microelectrodes for localizing seizure activity inadjacent regions. The multi-scale design validated here is the first to simultaneously measuremacro- and microelectrode signals from the same overlapping cortical area. This enables directcomparison of microelectrode recordings to the macroelectrode recordings used in standardneurosurgical practice. Previous studies have also shown that cortical regions generatinghigh-frequency oscillations are at an increased risk for becoming epileptogenic zones. Moreaccurate mapping of these micro seizures may improve surgical outcomes for epilepsy patients

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Multichannel Wireless Neurosensing System for battery-free monitoring of neuronal activity

Cited by 3 publications

References 32 publications

A novel hybrid Wireless Integrated Sensing Detector for simultaneous EEG and MRI (WISDEM)

A novel hybrid Wireless Integrated Sensing Detector for simultaneous EEG and MRI (WISDEM)

Wireless Battery-free and Fully Implantable Organ Interfaces

Development of a novel, concentric micro-ECoG array enabling simultaneous detection of a single location by multiple electrode sizes

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