Multiciliated ependymal cells: an update on biology and pathology in the adult brain

Groh, Adam M. R.; Song, Yeji Lori; Tea, Fiona; Lu, Brianna; Huynh, Stephanie; Afanasiev, Elia; Bigotte, Maxime; Del Bigio, Marc R.; Stratton, Jo Anne

doi:10.1007/s00401-024-02784-0

Acta Neuropathol

2024

DOI: 10.1007/s00401-024-02784-0

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Multiciliated ependymal cells: an update on biology and pathology in the adult brain

Adam M. R. Groh,

Yeji Lori Song,

Fiona Tea

et al.

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Cited by 2 publications

References 240 publications

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Follow the CSF flow: probing multiciliated ependymal cells in brain pathology

Groh,

Hodgson,

Bzdok

et al. 2024

Trends in Molecular Medicine

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Follow the CSF flow: probing multiciliated ependymal cells in brain pathology

Groh,

Hodgson,

Bzdok

et al. 2024

Trends in Molecular Medicine

View full text Add to dashboard Cite

Ependymal cells: roles in central nervous system infections and therapeutic application

Xie,

2024

J Neuroinflammation

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Ependymal cells are arranged along the inner surfaces of the ventricles and the central canal of the spinal cord, providing anatomical, physiological and immunological barriers that maintain cerebrospinal fluid (CSF) homeostasis. Based on this, studies have found that alterations in gene expression, cell junctions, cytokine secretion and metabolic disturbances can lead to dysfunction of ependymal cells, thereby participating in the onset and progression of central nervous system (CNS) infections. Additionally, ependymal cells can exhibit proliferative and regenerative potential as well as secretory functions during CNS injury, contributing to neuroprotection and post-injury recovery. Currently, studies on ependymal cell primarily focus on the basic investigations of their morphology, function and gene expression; however, there is a notable lack of clinical translational studies examining the molecular mechanisms by which ependymal cells are involved in disease onset and progression. This limits our understanding of ependymal cells in CNS infections and the development of therapeutic applications. Therefore, this review will discuss the molecular mechanism underlying the involvement of ependymal cells in CNS infections, and explore their potential for application in clinical treatment modalities.

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Multiciliated ependymal cells: an update on biology and pathology in the adult brain

Cited by 2 publications

References 240 publications

Follow the CSF flow: probing multiciliated ependymal cells in brain pathology

Follow the CSF flow: probing multiciliated ependymal cells in brain pathology

Ependymal cells: roles in central nervous system infections and therapeutic application

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