Multicolor Imaging for Detection of Retinal Nerve Fiber Layer Defect in Myopic Eyes With Glaucoma

Kim, Yong Hyun; Ahn, Jae In; Kim, Ko Eun

doi:10.1016/j.ajo.2021.07.022

Cited by 7 publications

(3 citation statements)

References 29 publications

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“…The resolution of each scan in MC-cSLO is 3.5 μm/pixel; thus, this approach produces clearer and more detailed images than CFP. Several studies have reported the usefulness of this technique for the detection of RNFL defects in retinal diseases ( 10 , 11 , 17 ). The present study found that the stage of LHON judged by the proportion of fiber bundle defects in standard MC, GR, BR, and GB was highly consistent with the course inferred by pRNFL thickness.…”

Section: Discussionmentioning

confidence: 99%

“…A standard MC image and green-blue-enhanced(BG)image are subsequently computed ( 9 ). Several studies have reported the usefulness of this approach for the detection of RNFL defects in glaucoma ( 10 , 11 ), but its application to LHON has not yet been fully investigated. Thus, we investigated the RNFL visibility score and characteristics of fiber bundle defect in patients with LHON, by MC and color fundus photography (CFP) in the present study.…”

Section: Introductionmentioning

confidence: 99%

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Clinical application of multicolor imaging in Leber hereditary optic neuropathy

Cheng

He²,

Miao³

et al. 2022

Front. Neurol.

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PurposeTo characterize features of retinal never fiber in Leber Hereditary Optic Neuropathy (LHON) using multicolor (MC) imaging and color fundus photography (CFP).MethodsNinety-two eyes of patients with LHON underwent MC imaging, optic disc spectral domain optical coherence tomography (SD-OCT), and CFP. Two independent observers graded RNFL visibility scores and two other experts determined never fiber bundle defects from four-quadrant readings. CFP, standard MC, infrared reflectance (IR), green reflectance (GR), blue reflectance (BR), and green-blue-enhanced (BG) imaging were compared.ResultsAgreement on never fiber bundle defects was substantial for CFP, standard MC, GR, BR, and BG images relative to IR. It was shown that BR (2.71 ± 0.55) had the best mean RNFL visibility score, BG (2.69 ± 0.52), GR (2.69 ± 0.56), standard MC (2.04 ± 0.79), CFP (1.80 ± 0.82), and IR (0.45 ± 0.59) followed. Agreement on temporal area defects was relatively improved. Youden's indices for CFP (78.21%), standard MC (84.48%), GR (90.92%), BR (89.64%), and BG (90.99%) indicated good detection of defects in the papillomacular bundle (PMB)/ high suspicion of patients with LHON, particularly for BG and GR. According to the proportion of never fiber bundle defects, standard MC, GR, BR, and BG can roughly determine the LHON clinical stage, especially in subacute and chronic stages, and standard MC is superior for patients with LHON of all stages. The stage judged by MC was consistent with the course inferred by pRNFL thickness.ConclusionAs an adjunct to SD-OCT, the MC image, particularly the GR and BG can delineate RNFL more effectively than CFP. The MC image may be a useful adjunct to OCT for detecting or monitoring never fiber bundle defects, providing inexpensive and rapid methods that can quickly identify patients with high suspicion of LHON.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical application of multicolor imaging in Leber hereditary optic neuropathy

Cheng

He²,

Miao³

et al. 2022

Front. Neurol.

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“…Visual field impairment is preceded by increased optic nerve papilla depression and structural damage to the retinal nerve fiber layer (RNFL), perceptible symptoms do not arise until the disease has progressed to its final stages 3 . Glaucoma has poor prognosis in advanced stages and is difficult to treat with surgery and medication; thus, detecting structural damage in the optic disc and RNFL in the early stages of glaucoma is crucial for its diagnosis and treatment 4 , 5 .…”

Section: Introductionmentioning

confidence: 99%

Diagnostic performance of wide-field optical coherence tomography angiography for high myopic glaucoma

Hong,

Kim,

Toh

et al. 2024

Sci Rep

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Diagnosing and monitoring glaucoma in high myopic (HM) eyes are becoming very important; however, it is challenging to diagnose this condition. This study aimed to evaluate the diagnostic ability of wide-field optical coherence tomography angiography (WF-OCTA) maps for the detection of glaucomatous damage in eyes with HM and to compare the diagnostic ability of WF-OCTA maps with that of conventional imaging approaches, including swept-source optical coherence tomography (SS-OCT) wide-field maps. In this retrospective observational study, a total 62 HM-healthy eyes and 140 HM eyes with open-angle glaucoma were included. Patients underwent a comprehensive ocular examination, including SS-OCT wide-field and 12 × 12 WF-OCTA scans. The WF-OCTA map represents the peripapillary and macular superficial vascular density maps. Glaucoma specialists determined the presence of glaucomatous damage in HM eyes by reading the WF-OCTA map and comparing its sensitivity and specificity with those of conventional SS-OCT images. The sensitivity and specificity of 12 × 12 WF-OCTA scans for HM-glaucoma diagnosis were 87.28% and 86.94%, respectively, while, the sensitivity and specificity of SS-OCT wide-field maps for HM-glaucoma diagnosis were 87.49% and 80.51%, respectively. The specificity of the WF-OCTA map was significantly higher than that of the SS-OCT wide-field map (p < 0.05). The sensitivity of the WF-OCTA map was comparable with that of the SS-OCT wide-field map (p = 0.078). The WF-OCTA map showed good diagnostic ability for discriminating HM-glaucomatous eyes from HM-healthy eyes. As a complementary method to an alternative imaging modality, WF-OCTA mapping can be a useful tool for the detection of HM glaucoma.

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