Multicolor imaging for retinal nerve fiber layer defect in glaucoma

Abstract

Glaucoma is a progressive optic neuropathy associated with irreversible loss of retinal ganglion cells (RGC). This emblematic localized retinal nerve fiber layer defect (RNFLD) can be the earliest sign to detect the ongoing glaucomatous damage. Slitlamp biomicroscopy [90D & 78D], colour and redfree fundus photography, OCT & HRT are used conventionally for early detection of RNFLD. Multicolour Imaging (MCI) is a new non-invasive retinal imaging modality available in Spectralis platform which simultaneously acquires three reflectance images of the retina using three individual lasers producing a composite image thereby allowing analysis of changes at various levels within the retina. MCI provides sharper image, enables imaging through small pupil and hazy media. Current report describes 2 cases where in MCI proved superior to CFP and conventional redfree photograph in delineating area of RNFLD. This is the first report of MCI in RNFL imaging. The present report highlights the role of MCI in detection of RNFLD.

Contribution at the Study of Neuroprotective Properties of Neuroglobin during Severe Chronic Glaucoma

“…Chronic glaucoma (CG) is an ischemic anterior optic neuropathy, resulting in blindness by progressive loss of axonal fibers of the optic nerve [1]- [8]. A study conducted in human in 2019 found an overexpression of plasma neuroglobine that depended not only on the severity, but also of the evolution of chronic glaucoma, but did not explain its mechanisms [40].…”