Multicomponent antihypertensive pharmaceuticals determination with related impurity analysis using MEKC: Whiteness and greenness assessment

Ahmed, Aya R.; Galal, Shereen M.; Korany, Mohamed A.; Ragab, Marwa A.A.

doi:10.1016/j.scp.2023.101066

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…The analytical methodology should strike a compromise between being environmentally friendly and functionality in terms of completing the scope of application with a high degree of accuracy and precision, saving time and money, and consuming less waste and harmful chemicals. Consequently, the greenness and whiteness of the current work were assessed and compared with reported HPLC [ 6 ], HPTLC [ 6 ], UPLC [ 10 ] and spectrophotometric [ 11 ] methods by using two green approaches, namely, the Analytical Eco-Scale [ 38 ] and the most novel Analytical Greenness metric (AGREE) [ 39 ] side by side with whiteness appraisal using the multicriteria RGB 12 model [ 40 , 41 ].…”

Section: Assessment Of Greenness and Whiteness Of The Proposed Methodsmentioning

confidence: 99%

Green and white MEKC for determination of different anti-diabetic binary mixtures and their triple-combo pill

et al. 2023

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The work introduces green and white sustainable micellar electrokinetic chromatography (MEKC) procedure that could analyze therapeutically related drugs, empagliflozin (EMP), linagliptin (LIN) and metformin (MET) which are antidiabetic drugs with different mechanism of action, in their different pharmaceutical combinations. The method not only comply with the green analytical concepts, but also it is in line with sustainable analytical concepts as it is economic by applying the same operating conditions to analyze different pharmaceuticals in quality control (QC) labs which is a crucial step in QC labs and research centers to save time, effort, and money. Moreover, the method functionality regarding its scope with its achieved levels of accuracy, precision, low detection, and quantitation limits is tested using white assessment tool and compared with reported methods. The proposed MEKC coupled with a diode array detector (DAD) has been developed and validated for micro estimation of EMP and LIN in their low critical concentrations with MET in a ratio of (EMP: MET, 1:40) and (LIN: MET, 1:200). Separation was achieved within 6 min using fused silica capillary (40 cm × 50 µm id) using 20 mM Tris buffer (pH 10) in presence of 50 mM sodium dodecyl sulphate and 10% v/v methanol. The concentration ranges of the studied anti-diabetic drugs were 10–500, 10–100 and 2.5–100 µg. mL−1 for MET, EMP and LIN, respectively. The developed method is the first MEKC for concurrent determination of EMP, LIN and MET with high separation efficiency, low solvent consumption and regard as an easy green and white analytical tool. Moreover, Greenness and whiteness assessment were done via the most widely used Analytical Eco-Scale, the innovative AGREE tool and the RGB 12 algorithm.

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Section: Assessment Of Greenness and Whiteness Of The Proposed Methodsmentioning

confidence: 99%

Green and white MEKC for determination of different anti-diabetic binary mixtures and their triple-combo pill

et al. 2023

Self Cite

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“…Furthermore, one of the current key areas of research involves the creation of white and green analytical procedures. [32][33][34][35][36][37][38][39] For this purpose, the Analytical Eco-Scale procedure, 40 Analytical GREEnness (AGREE) approach 41 and white RGB (Red-Green-Blue) 12 model 42 were employed in this work. Thus, we were able to clarify the sustainability, greenness and the whiteness of the suggested method, specically, with regard to the consumption of energy, the creation of waste, and dangerous chemicals.…”

Section: Nifuroxazidementioning

confidence: 99%

White sustainable luminescent determination of nifuroxazide using nitrogen–sulphur co-doped carbon quantum dots nanosensor in bulk and various pharmaceutical matrices

Elnaggar,

El-Yazbi,

Belal

et al. 2023

RSC Adv.

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Ecological assessment and development of analytical methods for concurrent quantification of valsartan and sacubitril: whiteness comparative study based on relative scoring

Kammoun,

Afify,

Youssef

et al. 2024

RSC Adv.

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Multicomponent antihypertensive pharmaceuticals determination with related impurity analysis using MEKC: Whiteness and greenness assessment

Cited by 4 publications

References 22 publications

Green and white MEKC for determination of different anti-diabetic binary mixtures and their triple-combo pill

Green and white MEKC for determination of different anti-diabetic binary mixtures and their triple-combo pill

White sustainable luminescent determination of nifuroxazide using nitrogen–sulphur co-doped carbon quantum dots nanosensor in bulk and various pharmaceutical matrices

Ecological assessment and development of analytical methods for concurrent quantification of valsartan and sacubitril: whiteness comparative study based on relative scoring

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