Multicomponent Reactions

Huang, Yijun; and, Ahmed Yazbak; Dömling, Alexander

doi:10.1002/9780470711828.ch18

Cited by 18 publications

(7 citation statements)

References 103 publications

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“…The one-pot multicomponent reaction approach is a powerful and straightforward route to various complex high value-added molecules. 1–4 In particular, multicomponent reactions provide valuable functionalized heterocyclic compounds containing a 4-aryltetrahydropyran moiety, 5–7 which is the core unit of many biologically active compounds including epicalyxin F and calyxins I and L with antiproliferative activity against human fibrosarcoma HT-1080, and murine colon 26-L5 carcinoma cells. 8–11 A one-pot acid-catalyzed Prins–Friedel–Crafts reaction between a carbonyl compound, a homoallylic alcohol and an aromatic hydrocarbon is an efficient method for the synthesis of heterocycles with the 4-aryltetrahydropyran moiety.…”

Section: Introductionmentioning

confidence: 99%

MWW-type zeolite nanostructures for a one-pot three-component Prins–Friedel–Crafts reaction

Barakov

Shcherban

Petrov

et al. 2022

Inorg. Chem. Front.

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Section: Introductionmentioning

confidence: 99%

MWW-type zeolite nanostructures for a one-pot three-component Prins–Friedel–Crafts reaction

Barakov

Shcherban

Petrov

et al. 2022

Inorg. Chem. Front.

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“…Green concepts, based on rational considerations, are increasingly included in MCR chemistry [ 124 , 133 , 156 , 157 , 158 ]. There is a renaissance of catalyst-free synthesis [ 124 ].…”

Section: Multicomponent Reactions (Mcrs)mentioning

confidence: 99%

Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)—The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules

Eckert

2017

Molecules

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Several novel methods, catalysts and reagents have been developed to improve organic synthesis. Synergistic effects between reactions, reagents and catalysts can lead to minor heats of reaction and occur as an inherent result of multicomponent reactions (MCRs) and their extensions. They enable syntheses to be performed at a low energy level and the number of synthesis steps to be drastically reduced in comparison with ‘classical’ two-component reactions, fulfilling the rules of Green Chemistry. The very high potential for variability, diversity and complexity of MCRs additionally generates an extremely diverse range of products, thus bringing us closer to the aim of being able to produce tailor-made and extremely low-cost materials, drugs and compound libraries.

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“…Green concepts, based on rational considerations, are increasingly included in MCR chemistry [126,135,158,159,160]. There is a renaissance of catalyst-free synthesis [126].…”

Section: Scheme 10 Postcondensation Cyclisations (Pccs) Of An Ugi-rementioning

confidence: 99%

Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)—The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules

Eckert

2017

Preprint

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Synergistic effects between reactions, reagents and catalysts can lead to minor heats of reaction and occur as an inherent result of multi-component reactions (MCRs) and their extensions. They enable syntheses to be performed at a low energy level and the number of synthesis steps to be drastically reduced in comparison with 'classical' two-component reactions. The very high potential for variability, diversity and complexity of MCRs additionally generates an extremely diverse range of products, thus bringing us closer to the aim of being able to produce tailor-made and extremely low-priced materials, drugs and libraries.Keywords: multicomponent reaction; MCR; post condensation modification PCM; post condensation cyclisation PCC; MFCR; multifunction catalysis; variability; diversity; complexity; efficiency of synthesis. PrologueThe high discrepancy between traditional feasibility mania and rational efficiency assessment in chemical synthesis became immediately apparent to the author while working on his thesis and during everyday laboratory life. On the one hand, classic peptide synthesis with an inefficient, extremely high number of synthesis steps and on the other hand, elegant multicomponent reactions that can make such efforts unnecessary. This double strategy in chemical synthesis has given the author cause to reflect (Picture 2) on how to close this gap using a consistent procedure. Picture 2. Problem in chemical syntheses relating to terms of producibility, ecology and economy.

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Multicomponent Reactions

Cited by 18 publications

References 103 publications

MWW-type zeolite nanostructures for a one-pot three-component Prins–Friedel–Crafts reaction

MWW-type zeolite nanostructures for a one-pot three-component Prins–Friedel–Crafts reaction

Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)—The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules

Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)—The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules

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Multicomponent Reactions

Cited by 18 publications

References 103 publications

MWW-type zeolite nanostructures for a one-pot three-component Prins–Friedel–Crafts reaction

MWW-type zeolite nanostructures for a one-pot three-component Prins–Friedel–Crafts reaction

Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)—The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules

Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)&mdash;The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules

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Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)—The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules