Multicomponent reactions in the synthesis of organochalcogen compounds

Barcellos, Angelita M.; Mangiavacchi, Francesca; Abenante, Laura; Dias, Italo Franco Coelho; Sacramento, Manoela

doi:10.1016/b978-0-12-819449-2.00002-1

Cited by 2 publications

(1 citation statement)

References 59 publications

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“…Classical multicomponent reactions are well known by their proper name and scope: Ugi [ 4 , 9 ], Passerini [ 6 , 10 ], van Leusen [ 11 , 12 ], Strecker [ 13 ], Orru [ 14 ], Mannich [ 6 , 15 ], Biginelli [ 6 , 16 , 17 ] and Hantzsch syntheses [ 6 , 18 ] need to be mentioned. However, the discovery of new multicomponent reactions is an active research field [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ], with novel exciting MCRs being discovered and incorporated to the synthetic armamentarium every year. Among these MCRs with transition metal catalysis [ 28 , 29 , 30 , 31 , 32 , 33 , 34 ], radical process [ 7 , 21 , 35 , 36 ] and organo-catalysis [ 37 , 38 , 39 , 40 , 41 ] should also be mentioned.…”

Section: Introduction: Multicomponent Reactionsmentioning

confidence: 99%

Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs

Graziano

Stefanachi

Contino

et al. 2023

IJMS

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Multicomponent reactions (MCRs) have emerged as a powerful strategy in synthetic organic chemistry due to their widespread applications in drug discovery and development. MCRs are flexible transformations in which three or more substrates react to form structurally complex products with high atomic efficiency. They are being increasingly appreciated as a highly exploratory and evolutionary tool by the medicinal chemistry community, opening the door to more sustainable, cost-effective and rapid synthesis of biologically active molecules. In recent years, MCR-based synthetic strategies have found extensive application in the field of drug discovery, and several anticancer drugs have been synthesized through MCRs. In this review, we present an overview of representative and recent literature examples documenting different approaches and applications of MCRs in the development of new anticancer drugs.

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