Multiconstituent identification in root, branch, and leaf extracts of <i>Juglans mandshurica</i> using ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry

Wang, Tianmin; Liu, Jing; Yi, Tao; Zhai, Yuanzheng; Zhang, Hui; Chen, Hubiao; Cai, Shao‐Qing; Kang, Ting-Guo; Zhao, Zhongzhen

doi:10.1002/jssc.201700521

Cited by 13 publications

(13 citation statements)

References 40 publications

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“…The compounds identified consisted of tannins, naphthalene derivatives, organic acids, flavonoids, diarylheptanoids, lignans, and anthraquinones. The result and the fragmentation pattern of those compounds identified was consistent with our previous report on the chemical profile of ethanol extract of J. mandshurica [ 33 ].…”

Section: Resultssupporting

confidence: 91%

“…Tannins were found to be the main constituents in the decoction and 45 tannins were characterized. The fragmentation pattern of these tannins was characterized by continuous loss of acyl and/or organic acid groups and presence of typical product ions of the corresponding organic acid ( Figure S1a ) [ 32 , 33 ]. The organic acid and the polyol carbohydrate core in the structure of the tannins identified mainly consisted of gallic acid and glucose, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Of the naphthalene derivatives identified, nine were glycosides with glycosyl groups or galloyl/syrigoyl-substituted glycosyl moieties. According to MS 2 analysis, fragmentation of these naphthalene derivatives involved the loss of H 2 O and CO 2 from deprotonated aglycon ions ( Figure S1b ) [ 33 , 37 ].…”

Section: Resultsmentioning

confidence: 99%

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Identification of Polar Constituents in the Decoction of Juglans mandshurica and in the Medicated Egg Prepared with the Decoction by HPLC-Q-TOF MS2

Wang

et al. 2017

Molecules

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As a folk medicinal plant, Juglans mandshurica has been used for the treatment of cancer in China and Korea. Traditionally, J. mandshurica is decocted together with chicken eggs. Both the decoction and medicated eggs possess anti-tumor properties. Clarifying the constituents of the decoction and absorbed by the medicated eggs is essential for the investigation of the active principles of J. mandshurica. Herein, the medicated eggs were prepared by decocting raw chicken eggs, having unbroken shells, with the decoction of J. mandshurica. A systematic investigation of the chemical profile of the J. mandshurica decoction and the medicated egg extraction was conducted by HPLC-Q-TOF-MS2. In total, 93 peaks, including 45 tannins, 14 naphthalene derivatives, 17 organic acids, 3 diarylheptanoids, 4 lignans, 3 anthraquinones, 1 flavonoid glycoside, 3 amino acids, and 3 nitrogenous compounds, were tentatively identified in the decoction. In the medicated egg extraction, 44 peaks including 11 organic acids, 3 amino acids, 3 nitrogenous compounds, 8 naphthalene derivatives, 3 diarylheptanoids, 15 tannins, and 1 lignan were tentatively identified. The chemical profile presented provided a detailed overview of the polar chemical constituents in J. mandshurica and useful information for the research of bioactive compounds of this plant.

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

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Identification of Polar Constituents in the Decoction of Juglans mandshurica and in the Medicated Egg Prepared with the Decoction by HPLC-Q-TOF MS2

Wang

et al. 2017

Molecules

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“…In addition, the identification of potential unique chemical markers present in various botanical extracts would aid in ensuring product integrity and prevent economic adulteration and counterfeiting of study materials. This has led to the utilization of analytical techniques, including, HPLC and LC–MS/MS analyses, for the characterization of botanical ingredients .…”

Section: Introductionmentioning

confidence: 99%

Liquid chromatography coupled with time‐of‐flight tandem mass spectrometry for comprehensive phenolic characterization of pomegranate fruit and flower extracts used as ingredients in botanical dietary supplements

Liu

Seeram

2018

J of Separation Science

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Pomegranate (Punica granatum L.) fruit and flower extracts, which are rich sources of bioactive phenolics, are widely utilized as ingredients in botanical dietary supplements. While the phenolic characterization of extracts of pomegranate fruit has been previously studied by liquid chromatography with tandem mass spectrometry, there is lack of similar data for pomegranate flowers. Herein, liquid chromatography with time-of-flight tandem mass spectrometry was utilized to comprehensively characterize the phenolics present in two pomegranate extracts, previously studied for their in vitro and in vivo biological effects, namely, a patented commercial pomegranate fruit extract (Pomella®), and a pomegranate flower extract. Seventy-one phenolics were characterized in the pomegranate fruit extract with the vast majority identified in the flower extract. However, only the pomegranate fruit extract contained tannin-glucuronides and two punicalagin isomers (a characteristic pomegranate phenolic) were identified in this extract while four were identified in the flower extract. The previously reported compounds, pomellatannin and punicatannins A/B, were identified as unique chemical markers in the pomegranate fruit and flower extracts, respectively. This study will aid in the quality control, authentication, and standardization of these botanical ingredients to evaluate their potential health benefits in future planned pre-clinical and clinical studies. Also, this is the first phenolic characterization of a pomegranate flower extract using liquid chromatography with tandem mass spectrometry.

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“…Its fresh rejuvenated fruit has been used traditionally as a medicine for treatment of cancer and dermatosis, and as an anodyne to relieve aches in China ( Liu et al, 2004a ). The nuts are extensively used as food because of its considerable nutritional value ( Wang et al, 2017b ; Mu et al, 2017 ). In Japan, several parts of this plant have been used in folk medicines and the fruits have been commonly used for the treatment of chilblains and athlete’s foot ( Machida et al, 2005 ).…”

Section: Botanical Description and Traditional Usagesmentioning

confidence: 99%

Juglans mandshurica Maxim.: A Review of Its Traditional Usages, Phytochemical Constituents, and Pharmacological Properties

Luan

Wang²,

Yang

et al. 2021

Front. Pharmacol.

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Juglans mandshurica Maxim., also known as “Manchurian walnut” (Chinese) and “Onigurumi” (Japanese), is a medicinal plant widely distributed in Western and Central Asia, especially in China. It has been traditionally used to treat cancer, gastric ulcers, diarrhea, dysentery, dermatosis, uterine prolapse, and leukopenia. To date, more than 400 constituents including quinones (e.g. naphthoquinones, anthraquinones, naphthalenones, tetralones), phenolics, flavonoids, triterpenoids, coumarins, lignans, phenylpropanoids, diarylheptanoids, and steroids, were isolated and structurally identified from different plant parts of J. mandshurica. Among them, quinones, phenolics, triterpenoids, and diarylheptanoids, as the major bioactive substances, have been extensively studied and displayed significant bioactivity. Previous studies have demonstrated that J. mandshurica and a few of its active components exhibit a wide range of pharmacologically important properties, such as antitumor, immunomodulatory, anti-inflammatory, neuroprotective, anti-diabetic, antiviral, antimicrobial, and anti-melanogenesis activities. However, many investigations on biological activities were mainly based on crude extracts of this plant, and the major bioactive ingredients responsible for these bioactivities have not been well identified. Further in vitro and in vivo studies on the mechanisms of action of the pure bioactive compounds, and more elaborate toxicity studies as well as clinical studies are needed to ensure safety and effectiveness of the plant for human use. Taken together, the present review will provide some specific useful suggestions guide to further investigations and applications of this plant in the preparation of medicines and functional foods.

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Multiconstituent identification in root, branch, and leaf extracts of Juglans mandshurica using ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry

Cited by 13 publications

References 40 publications

Identification of Polar Constituents in the Decoction of Juglans mandshurica and in the Medicated Egg Prepared with the Decoction by HPLC-Q-TOF MS2

Identification of Polar Constituents in the Decoction of Juglans mandshurica and in the Medicated Egg Prepared with the Decoction by HPLC-Q-TOF MS2

Liquid chromatography coupled with time‐of‐flight tandem mass spectrometry for comprehensive phenolic characterization of pomegranate fruit and flower extracts used as ingredients in botanical dietary supplements

Juglans mandshurica Maxim.: A Review of Its Traditional Usages, Phytochemical Constituents, and Pharmacological Properties

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