Multidetector computed tomography sizing of bioprosthetic valves: guidelines for measurement and implications for valve-in-valve therapies

Rajani, Ronak; Attia, Rizwan; Condemi, Fortunata; Webb, Jessica; Woodburn, P.; Hodson, Daniel J.; Nair, Arjun; Preston, Rebecca; Razavi, Reza; Bapat, Vinayak

doi:10.1016/j.crad.2015.10.013

Cited by 9 publications

(5 citation statements)

References 23 publications

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“…LncRNAs have emerged as critical regulators of gene expression and key players in many diseases3031. For example, the lncRNA NRF regulates programmed necrosis and myocardial injury during ischaemia and reperfusion by targeting miR-873; MEG3 promotes hepatic insulin resistance via increasing FoxO1 expression; and Lnc-CC3 increases metastasis in cervical cancer by increasing Slug expression3233. Collectively, lncRNAs have been investigated in different physiological and pathological processes for their ability to influence cell growth, survival, migration, and invasion181934.…”

Section: Discussionmentioning

confidence: 99%

The Lnc RNA SPRY4-IT1 Modulates Trophoblast Cell Invasion and Migration by Affecting the Epithelial-Mesenchymal Transition

Zuo

Huang

Zou

et al. 2016

Sci Rep

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Preeclampsia is a common, pregnancy-specific disease and a major contributor to maternal and foetal morbidity and mortality. Some placental abnormalities, including deficient implantation, abnormal trophoblast cell function, and improper placental vascular development, are believed to lead to preeclampsia. The long noncoding RNA SPRY4-IT1 is more highly expressed in preeclamptic human placentas than in normal placentas. We assessed the role of epithelial-mesenchymal transition (EMT)-associated invasion and migration in HTR-8/SVneo trophoblast cells. Overexpression of SPRY4-IT1 suppressed trophoblast cell migration and invasion, whereas reduced expression of SPRY4-IT1 prevented the EMT process. Mechanistically, an RNA immunoprecipitation experiment showed that SPRY4-IT1 bound directly to HuR and mediated the β-catenin expression associated with EMT in HTR-8/SVneo cells. Moreover, the expression levels of genes in the WNT family, such as WNT3 and WNT5B, were changed after transfection of HTR-8/SVneo with SPRY4-IT1. Together, our results highlight the roles of SPRY4-IT1 in causing trophoblast cell dysfunction by acting through the Wnt/β-catenin pathway, and consequently in impairing spiral artery remodelling. These results suggest a new potential therapeutic target for intervention against preeclampsia.

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Section: Discussionmentioning

confidence: 99%

The Lnc RNA SPRY4-IT1 Modulates Trophoblast Cell Invasion and Migration by Affecting the Epithelial-Mesenchymal Transition

Zuo

Huang

Zou

et al. 2016

Sci Rep

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“…In procedural planning, multidetector computed tomography is an important asset in both evaluation of the feasibility and the sizing of the degenerated bioprosthetic valves. 24 As we have underlined, ViV procedures present the optimal conditions for the development of an image-based assistance, given the propensity of surgical heart valve to preprocedural elaboration of CT data and segmentation. 25 Stented surgical heart valves present radio-opaque markers, 12 follow the constant motion of the heart, and present little or no deformation during the heart cycle.…”

Section: Discussionmentioning

confidence: 99%

Computer-Assisted Transcatheter Heart Valve Implantation in Valve-in-Valve Procedures

Soulami

Verhoye

Duc³

et al. 2016

Innovations�(Phila)

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Objective Valve-in-valve (ViV) procedures are increasingly being considered as an alternative to redo surgery for the treatment of degenerated bioprosthetic heart valves in patients with excessive reoperative risk. The objective of our study was to evaluate the feasibility of computer guidance in transcatheter heart valve (THV) implantation during ViV procedures. Methods Preprocedural electrocardiogram-gated computed tomography–scan images were processed using semiautomatic segmentation of the degenerated bioprosthesis’ radiopaque landmarks and of the ascending aorta. Virtual three-dimensional (3D) reconstructions were created. A virtual plane was subsequently added to the 3D reconstructions, indicating the optimal landing plane of the THV inside the tissue valve. Within a hybrid operating theater, a 3D/2D registration was used to superimpose the 3D reconstructions, while dynamic tracking was allowed to maintain the superimposition onto the fluoroscopic images. The THV was afterward implanted according to the optimal landing plane. Projection of the ascending aorta and the coronary arteries was used to assess the risk of coronary ostia obstruction. Results Between January 2014 and October 2014, nine patients underwent aortic ViV procedures in our institution. Among those nine patients, five procedures were retrospectively evaluated as a validation step using the proposed method. The mean (SD) superimposition error was 1.1 (0.75) mm. Subsequently, two live cases were prospectively carried out using our approach, successfully implanting the THV inside the degenerated tissue valve. Conclusions Our study demonstrates the feasibility of a computer-guided implantation of THV in ViV procedures. Moreover, it suggests that augmented reality may increase the reliability of THV implantation inside degenerated bioprostheses through better reproducibility.

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“…5 Post-processing the images with a sharper reconstruction kernel provides improved definition of the margins of the scaffold and a more accurate measurement of the true internal diameter. 6 Secondly, CT imaging is often required in the context of severe prosthesis dysfunction where aggressive rate control with beta-blockade may be clinically contraindicated. Of note, the clinical question plays an important role in selecting the appropriate phase.…”

Section: Cardiac Ct Image Acquisitionmentioning

confidence: 99%

Cardiac CT in prosthetic aortic valve complications

Andrews

Cartlidge

Dweck

et al. 2018

The British Journal of Radiology

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In the current era of transcatheter device therapy, the prevalence of prosthetic aortic valves and their associated complications is increasing. Echocardiography remains the first-line imaging investigation for the assessment of prosthetic valve complications, however, this often fails to identify the underlying mechanism of prosthesis failure. Recently, cardiac CT has emerged as an imaging technique capable of providing high isotropic spatial resolution of the prosthetic valve and its utility can provide important complementary diagnostic information. In this pictorial review, we present a series of common prosthetic aortic valve complications imaged with cardiac CT and demonstrate how use of this modality can enhance diagnostic accuracy.

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Multidetector computed tomography sizing of bioprosthetic valves: guidelines for measurement and implications for valve-in-valve therapies

Cited by 9 publications

References 23 publications

The Lnc RNA SPRY4-IT1 Modulates Trophoblast Cell Invasion and Migration by Affecting the Epithelial-Mesenchymal Transition

The Lnc RNA SPRY4-IT1 Modulates Trophoblast Cell Invasion and Migration by Affecting the Epithelial-Mesenchymal Transition

Computer-Assisted Transcatheter Heart Valve Implantation in Valve-in-Valve Procedures

Cardiac CT in prosthetic aortic valve complications

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