Multidirectional approaches on autofermented chamomile ligulate flowers: Antioxidant, antimicrobial, cytotoxic and enzyme inhibitory effects

Cvetanović, Aleksandra; Zeković, Zoran; Zengin, Gökhan; Mašković, Pavle; Petronijević, Mirjana; Radojković, Marija

doi:10.1016/j.sajb.2018.01.003

Cited by 15 publications

(7 citation statements)

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“…Traditionally, it is used to treat coughs, menstrual and gastrointestinal pains, rheumatism, eczema, skin irritations, gingivitis, and eye inflammations ( Vitalini et al, 2015 ). Its EO showed MICs of 10–156 μg/mL against E. coli , K. pneumoniae , Proteus mirabilis , P. vulgaris , MRSA and B. subtilis ( Cvetanović et al, 2019 ). α-bisabolol could be involved in the antibacterial activity observed ( Romero et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective

et al. 2021

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Background: Antimicrobial resistance represents a serious threat to human health across the globe. The cost of bringing a new antibiotic from discovery to market is high and return on investment is low. Furthermore, the development of new antibiotics has slowed dramatically since the 1950s’ golden age of discovery. Plants produce a variety of bioactive secondary metabolites that could be used to fuel the future discovery pipeline. While many studies have focused on specific aspects of plants and plant natural products with antibacterial properties, a comprehensive review of the antibacterial potential of plants has never before been attempted.Objectives: This systematic review aims to evaluate reports on plants with significant antibacterial activities.Methods: Following the PRISMA model, we searched three electronic databases: Web of Science, PubMed and SciFinder by using specific keywords: “plant,” “antibacterial,” “inhibitory concentration.”Results: We identified a total of 6,083 articles published between 1946 and 2019 and then reviewed 66% of these (4,024) focusing on articles published between 2012 and 2019. A rigorous selection process was implemented using clear inclusion and exclusion criteria, yielding data on 958 plant species derived from 483 scientific articles. Antibacterial activity is found in 51 of 79 vascular plant orders throughout the phylogenetic tree. Most are reported within eudicots, with the bulk of species being asterids. Antibacterial activity is not prominent in monocotyledons. Phylogenetic distribution strongly supports the concept of chemical evolution across plant clades, especially in more derived eudicot families. The Lamiaceae, Fabaceae and Asteraceae were the most represented plant families, while Cinnamomum verum, Rosmarinus vulgaris and Thymus vulgaris were the most studied species. South Africa was the most represented site of plant collection. Crude extraction in methanol was the most represented type of extraction and leaves were the main plant tissue investigated. Finally, Staphylococcus aureus was the most targeted pathogenic bacteria in these studies. We closely examine 70 prominent medicinal plant species from the 15 families most studied in the literature.Conclusion: This review depicts the current state of knowledge regarding antibacterials from plants and provides powerful recommendations for future research directions.

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Section: Discussionmentioning

confidence: 99%

A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective

et al. 2021

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“…In another study [ 37 ], the amylase- and glucosidase-inhibitory effects of the optimized extract for apigenin isolation were 0.45 mmol of ACAE/g and 2.54 mmol of ACAE/g, respectively. The values were also reported as 0.94 mmol of ACAE/g and 3.24 mmol of ACAE/g for autofermented chamomile ligulate flowers [ 38 ]. Taken together, chamomile extracts have significant enzyme inhibitory properties on anti-diabetic enzymes.…”

Section: Resultsmentioning

confidence: 99%

New Biological and Chemical Insights into Optimization of Chamomile Extracts by Using Artificial Neural Network (ANN) Model

Cvetanović

Radosavljević

Zengin

et al. 2023

Plants

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Chamomile is one of the most consumed medicinal plants worldwide. Various chamomile preparations are widely used in various branches of both traditional and modern pharmacy. However, in order to obtain an extract with a high content of the desired components, it is necessary to optimize key extraction parameters. In the present study, optimization of process parameters was performed using the artificial neural networks (ANN) model using a solid-to-solvent ratio, microwave power and time as inputs, while the outputs were the yield of the total phenolic compounds (TPC). Optimized extraction conditions were as follows: a solid-to-solvent ratio of 1:80, microwave power of 400 W, extraction time of 30 min. ANN predicted the content of the total phenolic compounds, which was later experimentally confirmed. The extract obtained under optimal conditions was characterized by rich composition and high biological activity. Additionally, chamomile extract showed promising properties as growth media for probiotics. The study could make a valuable scientific contribution to the application of modern statistical designs and modelling to improve extraction techniques.

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“…As inflorescências são utilizadas para a preparação de infusões e para a extração de óleo essencial, ambos com propriedades aromatizante e calmante. Também é matéria-prima para produtos farmacêuticos e cosméticos, pela ação anti-inflamatória, antisséptica e sedativa que a espécie promove (RAAL et al, 2012;CVETANOVIĆ et al, 2019).…”

Section: Introductionunclassified

“…Seus extratos, além da função medicinal, também podem ser utilizados em alimentos e bebidas e como repelente de insetos (TSIVELIKA et al, 2018). A bioatividade e os benefícios da camomila para a saúde estão associados ao óleo essencial, constituído por terpenos, como o α-bisabolol e seus derivados e camazuleno, bem como, no chá são encontrados compostos fenólicos incluindo apigenina, quercetina, luteolina e seus glicosídeos (CVETANOVIĆ et al, 2019;KHAYYAL et al, 2019). No entanto, a produção de flores depende das condições ambientais e das diversas práticas agrícolas, como a adubação mineral, que reflete diretamente nas características morfológicas e de rendimento desta cultura.…”

Section: Introductionunclassified

Principais Aplicações Das Plantas Medicinais Na Sociedade: Uma Abordagem Fitoquímica

Pereira¹,

Cruz²

2021

Tópicos Especiais Em Plantas Medicinais

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Atividades dos óleos essenciais sobre os microrganismos Óleos essenciais são metabólitos secundários produzidos por plantas aromáticas e podem estar presentes como misturas que compreendem terpenoides, especialmente monoterpenos (C10) e sesquiterpenos (C15), podendo incluir os diterpenos (C20). Nesta mistura podem estar presentes ácidos, álcoois, aldeídos, hidrocarbonetos alifáticos, ésteres acíclicos ou lactonas, compostos raros, contendo nitrogênio e enxofre; cumarinas e homólogos de fenilpropanoides (BAKKALI et al., 2007).De acordo com os mesmos autores, os óleos essenciais são considerados produtos naturais, com odor forte, líquidos, límpidos e coloridos, e geralmente são solúveis em lipídios e solventes orgânicos de densidade inferior à da água. Podem estar presentes em todos os órgãos das plantas, incluindo botões, flores, folhas, sementes, galhos, caules, frutos, raízes, madeira ou casca. Geralmente, os óleos essenciais são armazenados pelas plantas em células secretoras, cavidades, canais, tricomas glandulares ou células epidérmicas.A atividade antimicrobiana dos óleos essenciais deve-se à sua solubilidade na bicamada fosfolipídica das membranas celulares. Compreende, também, ação dos terpenoides, que são caracterizados por sua capacidade de interferir nas reações enzimáticas do metabolismo energético celular (KNOBLOCH et al., 1989). De acordo com Nazzaro et al., (2013), a característica de hidrofobicidade dos óleos faz com que os óleos essenciais rompam as estruturas bacterianas. Nas bactérias Gram-positivas, a característica da parede celular (peptideoglicano) favorece as moléculas hidrofóbicas a alcançarem o interior da célula. No caso das Gram-negativas, o lipopolissacarídeo que faz parte da constituição da parede celular permite a passagem das moléculas hidrofílicas e é parcialmente permissiva à passagem das hidrofóbicas (Figura 1). Fonte: Adaptado de Aiemsaard et al., (2011).De acordo com Amorena et al. (1999), o S. aureus diminui sua susceptibilidade aos antibióticos, quando encontrados em biofilmes, que após formados, necessitam de altas concentrações de óleo para difundir passivamente através da matriz de biofilme até atingir as bactérias. As concentrações inibitórias do óleo podem depender do coeficiente de difusão e características lipofílicas dos óleos testados. Além disso, é possível que os componentes dos óleos essenciais, tanto os compostos em maiores e menores concentrações, possam agir em conjunto, por sinergismo ou potencialização, contribuindo para a atividade antimicrobiana e antibiofilme.

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Multidirectional approaches on autofermented chamomile ligulate flowers: Antioxidant, antimicrobial, cytotoxic and enzyme inhibitory effects

Cited by 15 publications

References 40 publications

A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective

A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective

New Biological and Chemical Insights into Optimization of Chamomile Extracts by Using Artificial Neural Network (ANN) Model

Principais Aplicações Das Plantas Medicinais Na Sociedade: Uma Abordagem Fitoquímica

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