2024
DOI: 10.1002/advs.202404509
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Multidirectional Filamented Light Biofabrication Creates Aligned and Contractile Cardiac Tissues

Lewis S. Jones,
Miriam Filippi,
Mike Yan Michelis
et al.

Abstract: Biofabricating 3D cardiac tissues that mimic the native myocardial tissue is a pivotal challenge in tissue engineering. In this study, we fabricate 3D cardiac tissues with controlled, multidirectional cellular alignment and directed or twisting contractility. We show that multidirectional filamented light can be used to biofabricate high‐density (up to 60 × 106 cells mL−1) tissues, with directed uniaxial contractility (3.8x) and improved cell‐to‐cell connectivity (1.6x gap junction expression). Furthermore, by… Show more

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