Multidirectional Filamented Light Biofabrication Creates Aligned and Contractile Cardiac Tissues
Lewis S. Jones,
Miriam Filippi,
Mike Yan Michelis
et al.
Abstract:Biofabricating 3D cardiac tissues that mimic the native myocardial tissue is a pivotal challenge in tissue engineering. In this study, we fabricate 3D cardiac tissues with controlled, multidirectional cellular alignment and directed or twisting contractility. We show that multidirectional filamented light can be used to biofabricate high‐density (up to 60 × 106 cells mL−1) tissues, with directed uniaxial contractility (3.8x) and improved cell‐to‐cell connectivity (1.6x gap junction expression). Furthermore, by… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.