Multidisciplinary Center Care for Long COVID Syndrome–A Retrospective Cohort Study

Bailey, Joseph; Lavelle, Bianca; Miller, Janet L.; Jimenez, Millenia; Lim, Patrick H.; Orban, Zachary S.; Clark, Jeffrey R.; Tomar, Russell H.; Ludwig, Amy; Ali, Sareen T.; Lank, Grace K.; Zielinski, Allison; Mylvaganam, Ruben; Kalhan, Ravi; Muayed, Malek El; Mutharasan, R. Kannan; Liotta, Eric M.; Sznajder, Jacob I.; Davidson, Charles J.; Koralnik, Igor J.; Sala, Marc A.

doi:10.1016/j.amjmed.2023.05.002

Cited by 25 publications

(9 citation statements)

References 44 publications

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“…The lung epithelium is susceptible to viral, bacterial, and toxic insults, but this susceptibility is offset by a remarkable capacity to repair and regain function after injury. This regenerative capacity of the lung was seen recently in the majority of patients recovering from severe SARS-CoV-2 pneumonia ( 1 ). However, it declines with age, putting elderly people at disproportionate risk for mortality from acute and chronic lung diseases ( 2 ), as evidenced by the disproportionate impact of the COVID-19 pandemic on elderly populations ( 3 ).…”

Section: Introductionmentioning

confidence: 56%

Alveolar epithelial regeneration in the aging lung

Han,

Budinger,

Gottardi

2023

Journal of Clinical Investigation

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Advancing age is the most important risk factor for the development of and mortality from acute and chronic lung diseases, including pneumonia, chronic obstructive pulmonary disease, and pulmonary fibrosis. This risk was manifest during the COVID-19 pandemic, when elderly people were disproportionately affected and died from SARS-CoV-2 pneumonia. However, the recent pandemic also provided lessons on lung resilience. An overwhelming majority of patients with SARS-CoV-2 pneumonia, even those with severe disease, recovered with near-complete restoration of lung architecture and function. These observations are inconsistent with historic views of the lung as a terminally differentiated organ incapable of regeneration. Here, we review emerging hypotheses that explain how the lung repairs itself after injury and why these mechanisms of lung repair fail in some individuals, particularly the elderly.

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Section: Introductionmentioning

confidence: 56%

Alveolar epithelial regeneration in the aging lung

Han,

Budinger,

Gottardi

2023

Journal of Clinical Investigation

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“…Furthermore, the broad spectrum of persistent symptoms, including neuropsychiatric manifestations, aligns with the growing body of evidence that COVID-19 has multifaceted impacts on various systems [ 52 , 53 ]. This suggests that a multidisciplinary approach to patient care is warranted, involving specialists in neurology, psychiatry, internal medicine, and other fields [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Post COVID-19 Symptoms Among Infected Vaccinated Individuals: A Cross-Sectional Study in Saudi Arabia

Adly,

Saleh,

Garout

et al. 2023

J Epidemiol Glob Health

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Introduction Multiple studies investigated the endurance and occurrence of symptoms three months after SARS-CoV-2 infection. This study examines the possible effects of COVID-19 vaccination on the persistence of post-recovery symptoms. Patients and Methods A cross-sectional survey was conducted in Saudi Arabia to evaluate 14 prevalent long COVID-19 symptoms among vaccinated individuals. Patients self-reported their acute COVID-19 experience, demographic information, chronic conditions, vaccine history, and persistent symptoms. Results Of the 484 patients, four respondents were excluded from the study as they had not received the vaccine, and 111 (23.1%) were vaccinated but did not get infected and were also excluded. The remaining 369 (76.9%) reported COVID-19 and a vaccination and thus they were included in the study. The occurrence of post-COVID-19 symptoms was reported in 59 (16.1%) for ≤ 3 months, 202 (54.8%) experienced persistent symptoms 3–6 months, and 108 (29.1%) reported symptoms lasting > 6 months. In relation to age group, persistent symptoms 3–6 months after recovery was more common in those > 50 years and symptoms lasting > 6 months were more common in 30–50 years of age (p < 0.001). Persistence of symptoms for 3-6 months was more common in those who were infected prior to vaccination compared to those who were infected after vaccination (P < 0.001). Of the included patients, 323 (87.5%) rated their health as good, 41 (11.1%) considered it fair, and 5 (1.4%) described their well-being as poor or terrible. Conclusion The study provides information of persistent symptoms in vaccinated individuals who had recovered from COVID-19 and highlights the need for targeted interventions to alleviate post-COVID-19 symptoms. The study is limited by its reliance on self-reported data and potential selection bias. Future research is needed to understand the mechanisms underlying persistent symptoms in vaccinated individuals and to identify effective interventions for long COVID.

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“…The search for this inquiry yielded a total of 11 publications, with the identified publications compiled into a list of PMIDs and inputted into the CORACLE search interface (Figure 3A, left panel) [10][11][12][13][14][15][16][17][18][19][20] . We retained the default settings allowing for broad inclusion without discrimination based on article type, journal, or publication date, however, these advanced filtering options are available for more nuanced analysis.…”

Section: Literature Mining Example Using Coracle: Post-acute Sequele ...mentioning

confidence: 99%

CORACLE (COVID-19 liteRAture CompiLEr): A platform for efficient tracking and extraction of SARS-CoV-2 and COVID-19 literature, with examples from post-COVID with respiratory involvement

Piontkovskaya,

Luo,

Lindberg

et al. 2024

Preprint

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Background: During COVID-19 pandemic there emerged a need to efficiently monitor and process large volumes of scientific literature on the subject. Currently, as the pandemic is winding down, the clinicians encountered a novel syndrome - Post-acute Sequelae of COVID-19 (PASC) - that affects over 10% of those who contract SARS-CoV-2 and presents a significant and growing challenge in the medical field. The continuous influx of new research publications underscores a critical need for efficient tools for navigating the literature. Objectives: We aimed to develop an application which will allow monitoring and categorizing COVID-19-related literature through building publication networks and medical subject headings (MeSH) maps to be able to quickly identify key publications and publication networks. Methods: We introduce CORACLE (COVID-19 liteRAture CompiLEr), an innovative web application designed for the analysis of COVID-19-related scientific articles and the identification of research trends. CORACLE features three primary interfaces: The "Search" interface, which displays research trends and citation links; the "Citation Map" interface, allowing users to create tailored citation networks from PubMed Identifiers (PMIDs) to uncover common references among selected articles; and the "MeSH" interface, highlighting current MeSH trends and associations between MeSH terms. Results: Our web application, CORACLE, leverages regularly updated PubMed data to aggregate and categorize the extensive literature on COVID-19 and PASC, aiding in the identification of relevant research publication hubs. Using lung function in PASC patients as a search example, we demonstrate how to identify and visualize the interactions between the relevant publications. Conclusion: CORACLE proves to be an effective tool for the extraction and analysis of literature. Its functionalities, including the MeSH trends and customizable citation mapping, facilitate the discovery of relevant information and emerging trends in COVID-19 and PASC research.

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Multidisciplinary Center Care for Long COVID Syndrome–A Retrospective Cohort Study

Cited by 25 publications

References 44 publications

Alveolar epithelial regeneration in the aging lung

Alveolar epithelial regeneration in the aging lung

Post COVID-19 Symptoms Among Infected Vaccinated Individuals: A Cross-Sectional Study in Saudi Arabia

CORACLE (COVID-19 liteRAture CompiLEr): A platform for efficient tracking and extraction of SARS-CoV-2 and COVID-19 literature, with examples from post-COVID with respiratory involvement

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