Multidisciplinary Delphi Consensus on Safety of Combining Transarterial Radioembolization with Yttrium-90 Microspheres with Systemic Anticancer Agents for the Treatment of Liver Malignancy

Kennedy, Andrew S.; Brown, Daniel B.; Fakih, Marwan; Jeyarajah, Rohan; Jones, Suzanne; Liu, David; Pinato, David J.; Sangro, Bruno; Sharma, Navesh K.; Sze, Daniel Y.; Van Cutsem, Eric; Wasan, Harpreet S.

doi:10.1016/j.jvir.2024.06.006

Journal of Vascular and Interventional Radiology

2024

DOI: 10.1016/j.jvir.2024.06.006

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Multidisciplinary Delphi Consensus on Safety of Combining Transarterial Radioembolization with Yttrium-90 Microspheres with Systemic Anticancer Agents for the Treatment of Liver Malignancy

Andrew S. Kennedy,

Daniel B. Brown,

Marwan Fakih

et al.

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2024

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Cited by 2 publications

References 81 publications

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Radioembolization for hepatocellular carcinoma: updated strategies and evolving clinical applications

Chansangrat,

Gadani

2024

Hepatoma Res

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Primary liver cancer, particularly hepatocellular carcinoma (HCC), ranks among the top causes of cancer deaths worldwide. Traditionally, liver cancer has been associated with a dismal prognosis, which has led to extensive research into potential treatments. Over the past decade, there have been substantial advancements, particularly in the area of locoregional therapies such as radioembolization. This paper provides a summary of the expanding role of radioembolization in HCC treatment, emphasizing recent updates in therapeutic guidelines and ongoing clinical research.

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Radioembolization for hepatocellular carcinoma: updated strategies and evolving clinical applications

Chansangrat,

Gadani

2024

Hepatoma Res

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Clinical Results of Holmium-166 Radioembolization with Personalized Dosimetry for the Treatment of Hepatocellular Carcinoma

Kühnel,

Köhler,

Brachwitz

et al. 2024

JPM

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Transarterial radioembolization (TARE) with 166Ho-loaded microspheres is an established locoregional treatment for hepatocellular carcinoma (HCC), introduced in 2010. This study evaluates the clinical outcome of patients with HCC who underwent 166Ho-TARE with personalized dosimetry. Twenty-seven patients with 36 TARE procedures were analyzed. Treatment planning, execution, and evaluation was possible without complications in all cases. At the 3-month follow-up, disease control in the treated liver was achieved in 81.8% of patients (complete remission, partial remission, and stable disease in 36.4%, 31.8%, and 13.6%, respectively). The median overall survival (OS) was 17.2 months, and progression-free survival (PFS) in the treated liver was 11 months. Statistically significant positive correlations were observed between the achieved radiation dose for the tumor and both PFS (r = 0.62, p < 0.05) and OS (r = 0.48, p < 0.05), suggesting a direct dose–response relationship. The calculated achieved dose was 8.25 Gy lower than the planned dose, with relevant variance between planned and achieved doses in individual cases. These results confirm the efficacy of the 166Ho-TARE holmium platform and underscore the potential of voxel-based, personalized dosimetry to improve clinical outcomes.

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Multidisciplinary Delphi Consensus on Safety of Combining Transarterial Radioembolization with Yttrium-90 Microspheres with Systemic Anticancer Agents for the Treatment of Liver Malignancy

Cited by 2 publications

References 81 publications

Radioembolization for hepatocellular carcinoma: updated strategies and evolving clinical applications

Radioembolization for hepatocellular carcinoma: updated strategies and evolving clinical applications

Clinical Results of Holmium-166 Radioembolization with Personalized Dosimetry for the Treatment of Hepatocellular Carcinoma

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