Multidrug encapsulation by coaxial tri-capillary electrospray

Advances in drug delivery via electrospun and electrosprayed nanomaterials

“…[34][35][36] Although single-step synthesis of solid particles is considered one of the main advantages of EHDA, a grounded conductive solution can be used as the collector, in case colloidal solutions of particles are required for a particular application. 27,31,37 This method enables integration of probable post electrospraying surface-modification process with a particle-collecting step. 30,[38][39][40] Considering the specific requirements of suitable drugdelivery devices for different diseases and also the wide variety of drug characteristics, such as stability and solubility, various techniques might be needed to desirably incorporate the target therapeutic agent into electrospun nanofibers or electrosprayed particles.…”

“…Instead, it is carried out to modulate the surface properties of the particles to obtain desired results. Since an EHDA device offers the possibility of using a liquid-phase particle-collecting medium, it would be beneficial for stabilization of electrosprayed particle suspension, 31,37 and for further particle-surface modifications, such as coating 38,39 and cross-linking. 30,40,64 Almería et al reported the application of PVA in deionized water as the collecting medium whereby, PVA uniformly coated the PLGA drug-containing particles by binding onto the PLGA surface.…”

“…71 However, the size and internal structure of core-shell particles have to be precisely controlled, since the release kinetics is mainly determined by drug diffusion through the polymeric shell. 37 It was demonstrated that the coaxial dual-capillary electrospray is capable of producing monodisperse drug-loaded particles with high encapsulation efficiency. 37 Coaxial tricapillary electrospraying is another technique for fabrication of particles with core-middle-shell structure, which can be used for the production of multidrug-loaded particles.…”

“…37 It was demonstrated that the coaxial dual-capillary electrospray is capable of producing monodisperse drug-loaded particles with high encapsulation efficiency. 37 Coaxial tricapillary electrospraying is another technique for fabrication of particles with core-middle-shell structure, which can be used for the production of multidrug-loaded particles. Recent clinical studies have demonstrated higher effectiveness of multiple drug delivery compared to single drug administration, eg, in cancer therapy.…”

Tri-Needle Coaxial Electrospray Engineering of Magnetic Polymer Yolk–Shell Particles Possessing Dual-Imaging Modality, Multiagent Compartments, and Trigger Release Potential

“…[17][18] One such area of focus has centered on encapsulated polymeric particulate systems; with conceptual designs demonstrated in bi-layer, multi-layered and several other complex systems. [19][20][21] Among all polymeric particulate formats with compartmentalized (interior) structures, yolkshell particles (YSPs) appear least explored although they display unique features and physical properties; including low densities, large surface areas and excellent loading capacities.…”