Multifaceted polymersome platforms: Spanning from self-assembly to drug delivery and protocells

Balasubramanian, Vimalkumar; Herranz-Blanco, Bárbara; Almeida, Patrick; Hirvonen, Jouni; Santos, Hélder A.

doi:10.1016/j.progpolymsci.2016.04.004

Cited by 92 publications

(97 citation statements)

References 229 publications

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“…Vesicles (e.g., polymerosomes and liposomes) can be defined as an enclosure of fluid surrounded by a bilayer of amphiphilic molecules . The conventional preparation methods are cosolvent method (solvent switch, where the amphiphilic molecules are dissolved in organic solvent, before gradually adding an aqueous solution), film rehydration method (organic solvent is used to dissolve the amphiphilic molecules, before being completely evaporated, creating a film of the amphiphiles, ready to be rehydrated with aqueous solutions), and direct dissolution method (amphiphiles precipitate in the water solution, followed by a self‐assembly process) . Each of these methods lead to a vesicle population with quite wide polydispersion, and the need for further homogenization steps …”

Section: Microfluidic Production Of Microparticles/dropletsmentioning

confidence: 99%

Microfluidics for Production of Particles: Mechanism, Methodology, and Applications

Liu

Fontana

Python

et al. 2019

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In the past two decades, microfluidics‐based particle production is widely applied for multiple biological usages. Compared to conventional bulk methods, microfluidic‐assisted particle production shows significant advantages, such as narrower particle size distribution, higher reproducibility, improved encapsulation efficiency, and enhanced scaling‐up potency. Herein, an overview of the recent progress of the microfluidics technology for nano‐, microparticles or droplet fabrication, and their biological applications is provided. For both nano‐, microparticles/droplets, the previously established mechanisms behind particle production via microfluidics and some typical examples during the past five years are discussed. The emerging interdisciplinary technologies based on microfluidics that have produced microparticles or droplets for cellular analysis and artificial cells fabrication are summarized. The potential drawbacks and future perspectives are also briefly discussed.

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Section: Microfluidic Production Of Microparticles/dropletsmentioning

confidence: 99%

Microfluidics for Production of Particles: Mechanism, Methodology, and Applications

Liu

Fontana

Python

et al. 2019

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“…Looking ahead, some possible applications and problems that need to be solved are proposed. The synthesis of block copolymer GTPs can evidently expand the application fields of GTP . (2) The synthesis of anionic GTPs as ion‐conductive materials is also interesting.…”

Section: Summary and Outlook For The Futurementioning

confidence: 99%

Glycidyl Triazolyl Polymers: Poly(ethylene glycol) Derivatives Functionalized by Azide–Alkyne Cycloaddition Reaction

Ikeda

2018

Macromol. Rapid Commun.

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Glycidyl triazolyl polymer (GTP), which is the product of the Huisgen dipolar cycloaddition reaction between glycidyl azide polymer and alkyne derivatives, is featured here. GTP is the multifunctionalized poly(ethylene glycol) (PEG). The drawback of PEG is that linear PEG has the functional group only at both ends. The low loading capability of the functional groups limits the possibilities of PEG applications. GTP facilitates the synthesis of multifunctionalized PEG derivatives. In this article, 74 examples of GTP homopolymers and copolymers are introduced. The synthetic protocols and work-up processes of GTP are summarized. In addition, application studies are reviewed: for example, stimuli-responsive and self-healing materials, materials for electrical memory devices, ion-conductive materials, and biomedical materials. Finally, some issues on GTP synthesis and future directions for GTP-based polymer materials are proposed.

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“…In particular, self-assembly of BCPs upon microphase separation has been studied intensively [1,2], and the resulting nanoarchitectures have been utilized for biomedical applications [3,4], various nanotechnologies including nanolithography [5,6], and separation membranes [7]. POE-containing block copolymers (for example Pebax, a linear multiblock of POE and poly(ester-amide) segments) have been developed as membrane materials for CO 2 capture [8][9][10] due to the inherent CO 2 -philic nature of POE [11].…”

Section: Introductionmentioning

confidence: 99%

A strategy to enhance CO2 permeability of well-defined hyper-branched polymers with dense polyoxyethylene comb graft

Taniguchi

Wada

Kinugasa

et al. 2017

Journal of Membrane Science

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Multifaceted polymersome platforms: Spanning from self-assembly to drug delivery and protocells

Cited by 92 publications

References 229 publications

Microfluidics for Production of Particles: Mechanism, Methodology, and Applications

Microfluidics for Production of Particles: Mechanism, Methodology, and Applications

Glycidyl Triazolyl Polymers: Poly(ethylene glycol) Derivatives Functionalized by Azide–Alkyne Cycloaddition Reaction

A strategy to enhance CO2 permeability of well-defined hyper-branched polymers with dense polyoxyethylene comb graft

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