Multifarious applications of bioactive glasses in soft tissue engineering

Majumdar, Shreyasi; Gupta, Smriti; Krishnamurthy, Sairam

doi:10.1039/d1bm01104a

Cited by 10 publications

(12 citation statements)

References 212 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the regenerative potential of bioactive glasses was demonstrated not only for hard but also for soft tissues with limited renewal capacity. 153 Bioactive glasses were incorporated into hydrogels to investigate their osteoconductivity inside hydrogels and also to test the changes in the elasticity of hydrogels. 151 As evidenced earlier, antimicrobial features could be added to bioactive glass particles by doping metal ions (e.g., silver, copper, and iron) into the molecular structure.…”

Section: Biomaterials Science Reviewmentioning

confidence: 99%

Advances in antimicrobial hydrogels for dental tissue engineering: regenerative strategies for endodontics and periodontics

Atila,

Kumaravel

2023

Biomater. Sci.

View full text Add to dashboard Cite

show abstract

Section: Biomaterials Science Reviewmentioning

confidence: 99%

Advances in antimicrobial hydrogels for dental tissue engineering: regenerative strategies for endodontics and periodontics

Atila,

Kumaravel

2023

Biomater. Sci.

View full text Add to dashboard Cite

show abstract

“…Bioactive glasses (BGs) are bio- and cytocompatible third-generation silica-based inorganic compounds that have tremendous tissue regenerative potential . Their bioactivity is mainly due to various therapeutic dopants present in its silica network that are leached into the physiological environment, , which activates a cascade of proteins or ion channels required for physiological activity. Preclinically, BGs have been reported to possess several biological effects and are used topically as a hemostatic agent for wound healing. , They also facilitate neovascularization and are used as cardiac patches to prevent anoikis .…”

Section: Introductionmentioning

confidence: 99%

“…45S5 (Bioglass), the parent inorganic biomimetic BGs, has a silicate framework with calcium ions present as a network modifier. , Following this, several therapeutic ions have been doped in the BG framework, which imparts enhanced pharmacological activity and therapeutic efficacy. , One such trace nonessential element for the human body is barium, reported to be involved in the calcification of the skeletal system. , Further, barium salts are also used as diagnostic radiocontrast agents and have several biological properties. ,, Therefore, barium was doped into the bioglass framework (BaBG) and exhibited antiulcer properties in rats . Notably, BaBG has also been shown to possess in vitro regeneration potential in addition to the anti-inflammatory properties in LPS-induced neuroinflammation.…”

Section: Introductionmentioning

confidence: 99%

Oral Release Kinetics, Biodistribution, and Excretion of Dopants from Barium-Containing Bioactive Glass in Rats

Majumdar,

Tiwari,

Mallick

et al. 2024

ACS Omega

Self Cite

View full text Add to dashboard Cite

Background: Inorganic biomaterials are biologically active and are used as implants and drug delivery system. They have therapeutically active elements present in their framework that are released in the physiological milieu. Release of these dopants above the supraphysiological limit may produce adverse effects and physicochemical interactions with the loaded drugs. Therefore, this necessitates evaluating the in vivo release kinetics, biodistribution, and excretion profiles of dopants from barium-doped bioglass (BaBG) that has potential antiinflammatory, antiulcer, and regenerative properties. Methods: In vitro leaching of Ca, Si, and Ba from BaBG was analyzed in simulated body fluid. Release kinetics post single-dose oral administration (1, 5, and 10 mg/kg) was performed in rats. Blood was collected at different time points, and pharmacokinetic parameters of released elements were calculated. The routes of excretion and biodistribution in major organs were evaluated using ICP-MS. Results: Elements were released after the oral administration of BaBG into the plasma. They showed dose-dependent release kinetics and mean residence time. C max was observed at 24 h for all elements, followed by a downhill fall. There was also a dose-dependent increase in the volume of distribution, and the clearance of dopants was mostly through feces. Ba and Si were biodistributed significantly in the liver, spleen, and kidneys. However, by the end of day 7, there was a leveling-off effect observed for all elements. Conclusion: All of the dopants exhibited a dose-dependent increase in release kinetics and biodistribution in vital organs. This study will help in dose optimization and understanding of various physicochemical and pharmacokinetic interactions when BaBG is used for future pharmacological studies.

show abstract

“…Also, they are good candidates for soft tissue engineering applications. [12,13] Thus, destroying the cancerous hard and soft tissues during treatment. Likewise, they also aid in recuperation of the affected bone parts.…”

Section: Introductionmentioning

confidence: 99%

“…They are known for their bioactive reaction with physiological liquids within the affected bone leading to the formation of healthy bone cells. Also, they are good candidates for soft tissue engineering applications [12,13] . Thus, destroying the cancerous hard and soft tissues during treatment.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Mesoporous Core Shell Magnetite Bioactive Glass Nanoparticles for Magnetic Hyperthermia Treatment of Cancer

Goel,

Santhiya,

Kumar

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

Multiple biological advances have made use of bioactive glass (BG) nanoparticles (NPs) in regenerative medicine, bone and tooth repair, drug and gene transfer, cancer treatment, and cosmetics. Normal biocompatible coatings alongside hydrocarbons, polymers, and silica significantly affect fundamental attributes of NPs. In this study, we synthesized a novel mesoporous BG NPs with magnetite core shell (AMAG_BG) using L‐arginine as a template processing magnetic hyperthermia (MH). BG network coverage on magnetite (AMAG) NPs were orchestrated first time by bio‐inspired synthesis in watery dissolvable. AMAG and AMAG_BG NPs were characterized by utilizing FE‐SEM, HR‐TEM, and BET analysis. The elemental composition of L‐arginine templated magnetite (AMAG) and AMAG_BG NPs was also determined by XPS and EDX analysis. Characteristics of AMAG_BG were contrasted with bare AMAG NPs in morphology, particle size, porosity, and composition. The fabricated BG NPs′ in‐vitro bioactivity and heat studies were successfully monitored after interaction with simulated bodily fluid (SBF). Magnetic studies and in‐vitro heat studies together demonstrated the behavior of BG NPs towards MH treatment of cancerous cells. Cytotoxicity tests on AMAG_BG NPs using U2OS and human blood cells with appropriate control experiments revealed biocompatibility. The study represents magnetic and thermal property‐dependent sustainable synthetic process of AMAG BG NPs for cancer treatment.

show abstract

Multifarious applications of bioactive glasses in soft tissue engineering

Abstract: Tissue engineering (TE), a new paradigm in regenerative medicine, repairs and restores the diseased or damaged tissues and eliminates drawbacks associated with autograft and allograft. In this context, many biomaterials...

Cited by 10 publications

References 212 publications

Advances in antimicrobial hydrogels for dental tissue engineering: regenerative strategies for endodontics and periodontics

Advances in antimicrobial hydrogels for dental tissue engineering: regenerative strategies for endodontics and periodontics

Oral Release Kinetics, Biodistribution, and Excretion of Dopants from Barium-Containing Bioactive Glass in Rats

Synthesis of Mesoporous Core Shell Magnetite Bioactive Glass Nanoparticles for Magnetic Hyperthermia Treatment of Cancer

Contact Info

Product

Resources

About