Multifarious roles of metal elements in bone mineralization

Du, Tianming; Niu, Xufeng; Cao, Peng; Zhang, Yanping; Liu, Youjun; Yang, Haisheng; Qiao, Aike

doi:10.1016/j.apmt.2023.101810

Cited by 6 publications

(3 citation statements)

References 273 publications

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“…Our previous results demonstrated the observed synergistic effect between calcium ions and the dipeptide YR on the proliferation of human osteoblasts [ 8 ]. Given the presence of various metal elements during the mineralization step in the bone matrix [ 20 ], we investigated the effect of different metal ions in the presence of dipeptide YR on osteoblast proliferation in this study. Osteoblast growth was measured in the presence of 0.45 μM dipeptide YR and 3.6 μM various metal ions ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

Biological Activities of Deer Antler-Derived Peptides on Human Chondrocyte and Bone Metabolism

Ho,

Tsai,

et al. 2024

Pharmaceuticals

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Orally administered “tortoiseshell and deer antler gelatin” is a common traditional medicine for patients with osteoporosis or osteoarthritis. From the pepsin-digested gelatin, we previously isolated and identified the osteoblast-stimulating pentapeptide, TSKYR. Its trypsin digestion products include the dipeptide YR, enhancing calcium ion uptake, and tripeptide TSK, resulting in remarkable 30- and 50-fold increases in mineralized nodule area and density in human osteoblast cells. These peptides were chemically synthesized in this study. The composition of deer antler preparations comprises not only proteins and peptides but also a significant quantity of metal ion salts. By analyzing osteoblast growth in the presence of peptide YR and various metal ions, we observed a synergistic effect of calcium and strontium on the effects of YR. Those peptides could also stimulate the growth of C2C12 skeletal muscle cells and human chondrocytes, increasing collagen and glycosaminoglycan content in a three-dimensional environment. The maintenance of bone homeostasis relies on a balance between osteoclasts and osteoblasts. Deer antler peptides were observed to inhibit osteoclast differentiation, as evidenced by ROS generation, tartrate-resistant acid phosphatase (TRACP) activity assays, and gene expression in RAW264.7 cells. In summary, our findings provide a deep understanding of the efficacy of this folk medicine.

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Section: Resultsmentioning

confidence: 99%

Biological Activities of Deer Antler-Derived Peptides on Human Chondrocyte and Bone Metabolism

Ho,

Tsai,

et al. 2024

Pharmaceuticals

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“…A variety of metal elements, such as magnesium (Mg), zinc (Zn), manganese (Mn), strontium (Sr), copper (Cu), cobalt (Co), ferrum (Fe), aluminium (Al), nickel (Ni), and chromium (Cr), have been found to induce proliferation during tissue regeneration [66]. They also play an important role in promoting bone biomineralization [67]. Therefore, the introduction of metal elements can not only improve the mechanical properties of HA bioceramics but also promote the proliferation, differentiation, and migration of active cells in the bone to regulate bone mineralization.…”

Section: Non-weight-bearing Bone Implantsmentioning

confidence: 99%

Biomechanical Characteristics and Analysis Approaches of Bone and Bone Substitute Materials

Niu

Liu

2023

JFB

Self Cite

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Bone has a special structure that is both stiff and elastic, and the composition of bone confers it with an exceptional mechanical property. However, bone substitute materials that are made of the same hydroxyapatite (HA) and collagen do not offer the same mechanical properties. It is important for bionic bone preparation to understand the structure of bone and the mineralization process and factors. In this paper, the research on the mineralization of collagen is reviewed in terms of the mechanical properties in recent years. Firstly, the structure and mechanical properties of bone are analyzed, and the differences of bone in different parts are described. Then, different scaffolds for bone repair are suggested considering bone repair sites. Mineralized collagen seems to be a better option for new composite scaffolds. Last, the paper introduces the most common method to prepare mineralized collagen and summarizes the factors influencing collagen mineralization and methods to analyze its mechanical properties. In conclusion, mineralized collagen is thought to be an ideal bone substitute material because it promotes faster development. Among the factors that promote collagen mineralization, more attention should be given to the mechanical loading factors of bone.

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“…For example, the ions of some metals, including titanium, magnesium, and silver, show great biological potentials as they commonly exist in the human body and participate in most metabolic reactions [7]. Doping with these metal ions can also bring some extra benefits like the antibacterial ability to ensure overall performance of HA [8,9].…”

Section: Introductionmentioning

confidence: 99%

Metal Ion-Doped Hydroxyapatite-Based Materials for Bone Defect Restoration

Wang,

Huang,

Peng

2023

Bioengineering

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Hydroxyapatite (HA)-based materials are widely used in the bone defect restoration field due to their stable physical properties, good biocompatibility, and bone induction potential. To further improve their performance with extra functions such as antibacterial activity, various kinds of metal ion-doped HA-based materials have been proposed and synthesized. This paper offered a comprehensive review of metal ion-doped HA-based materials for bone defect restoration based on the introduction of the physicochemical characteristics of HA followed by the synthesis methods, properties, and applications of different kinds of metal ion (Ag+, Zn2+, Mg2+, Sr2+, Sm3+, and Ce3+)-doped HA-based materials. In addition, the underlying challenges for bone defect restoration using these materials and potential solutions were discussed.

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Multifarious roles of metal elements in bone mineralization

Cited by 6 publications

References 273 publications

Biological Activities of Deer Antler-Derived Peptides on Human Chondrocyte and Bone Metabolism

Biological Activities of Deer Antler-Derived Peptides on Human Chondrocyte and Bone Metabolism

Biomechanical Characteristics and Analysis Approaches of Bone and Bone Substitute Materials

Metal Ion-Doped Hydroxyapatite-Based Materials for Bone Defect Restoration

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