1999
DOI: 10.1002/(sici)1097-4598(199905)22:5<560::aid-mus2>3.0.co;2-q
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Multifocal acquired demyelinating sensory and motor neuropathy: The Lewis-Sumner syndrome

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Cited by 250 publications
(221 citation statements)
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“…Persistent conduction blocks in motor and sensory fibers are typical. Similar to CIDP, there is a favorable response to plasmapheresis, steorids or intravenous immunoglobulin (IVIg), and CSF protein is increased in 60-80% of patients with MADSAM neuropathy (1,17). Our patient demonstrated the definitive clinical and electrophysiologic picture of MADSAM neuropathy, along with elevated CSF protein, contrast enhancement in cauda equina, and significant response to steroids.…”
Section: Discussionmentioning
confidence: 58%
“…Persistent conduction blocks in motor and sensory fibers are typical. Similar to CIDP, there is a favorable response to plasmapheresis, steorids or intravenous immunoglobulin (IVIg), and CSF protein is increased in 60-80% of patients with MADSAM neuropathy (1,17). Our patient demonstrated the definitive clinical and electrophysiologic picture of MADSAM neuropathy, along with elevated CSF protein, contrast enhancement in cauda equina, and significant response to steroids.…”
Section: Discussionmentioning
confidence: 58%
“…Eine weitere differentialdiagnostisch zu berücksichtigende Form der erworbenen immunvermittelten demyelinisierenden Neuropathien stellt das LewisSumner-Syndrom dar (MADSAM/ multifocal aqcuired demyelinating sensory and motor neuropathy). Diese Erkrankung geht klinisch und elektrophysiologisch mit asymmetrischen multifokalen sensomotorischen Ausfällen einher, die wie die MMN eher den Verläufen einzelner peripherer Nerven folgt [3,25,26].…”
Section: Elektrophysiologie Und Diagnosestellungunclassified
“…When weakness is asymmetric, further classification hinges around the presence or absence of sensory signs. Asymmetric distal weakness without sensory loss is indicative of multifocal motor neuropathy (MMN) whereas sensory loss would suggest multifocal acquired demyelinating sensory and motor (MADSAM) neuropathy (Lewis-Sumner syndrome) [21][22][23][24]. Up to half of the MMN patients also have serum GM-1 antibodies and most DADS patients have an IgM monoclonal protein in the serum, often accompanied by antibodies to myelin-associated glycoprotein (MAG).…”
Section: Cidp Clinical Featuresmentioning
confidence: 99%
“…Initial involvement is usually in the arms, with later spread to distal legs. Unlike MMN, MADSAM neuropathy is not associated with anti-GM1 antibodies [21,[25][26][27]. As in MMN and CIDP, nerve conduction studies in MADSAM neuropathy shows conduction block, temporal dispersion, prolonged distal latencies, slow conduction velocities, and delayed or absent F-waves in one or more motor nerves.…”
Section: Cidp Clinical Featuresmentioning
confidence: 99%
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