Multifocal ectopic thyroid tissues including breast: A case report

Moon, Ahrim; Kim, Hyunsoo; Chang, Kyungseek; Im, Sung Il

doi:10.3892/mco.2019.1968

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…More importantly, the patient's own wishes must be respected. Recently, multifocal ectopic thyroid tissues in the breast of a 53-year-old woman was reported in Korea (18). Despite the lack of standard therapy due to the condition's rarity, the patient did not show symptoms related to thyroid hormones, and no further surgery was performed with the consent of the patient and her family.…”

Section: Discussionmentioning

confidence: 99%

Ectopic thyroid as multiple nodules in bilateral lung lobes: a case report

Cheng¹,

Jiang²,

Jiang³

2020

Gland Surg

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Ectopic thyroid rarely occurs in the thoracic or abdominal cavity, especially in the lung. Here, we describe an intrapulmonary thyroid tissue case in bilateral lung lobes without thyroid malignant history, which was found during a routine physical examination. A 37-year-old Chinese female showed multiple pulmonary nodules appearing in bilateral lung lobes on a computed tomography (CT) scan during a routine medical examination. To rule out the possibility of lung metastasis from occult cancer, a percutaneous lung biopsy was performed on a larger nodule. Histopathological examination confirmed that the nodule was completely consistent with normal thyroid tissue, which prevented the patient from requiring any unnecessary treatment. During the patient's follow-up, there was no abnormal thyroid function, and there was no change in the size of the nodule in the lung during serial CT scan. Currently, there is no guidance or consensus on the diagnosis of ectopic thyroid with bilateral multiple pulmonary nodules due to its rarity in clinical practice. When such pulmonary nodules are encountered, very careful diagnosis and follow-up should be performed.

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Section: Discussionmentioning

confidence: 99%

Ectopic thyroid as multiple nodules in bilateral lung lobes: a case report

Cheng¹,

Jiang²,

Jiang³

2020

Gland Surg

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“…The most common ectopic thyroid site is represented by the tongue (the lingual thyroid is involved in 90% of all ectopic cases; of note, the first ectopic thyroid tissue at this level was described in 1869 by Dr. Hickman in a newborn with rapidly fatal outcome due to respiratory obstruction) followed by various locations (that are called sublingual type [17]) such as submandibular [18], peri-tracheal, larynx, sub-diaphragmatic area [12], etc. Across these 10% of ectopic cases, the most uncommon sites that are only partially understood based on the embryogenetic perspective are at the gastrointestinal level, including the gallbladder [19], adrenal glands, ovaries (struma ovarii), lumbar/renal [19][20][21][22], axillary [23], mammary [24], supra-sellar and suprachiasmatic [25]. The mediastinal location may be easily explained by the local attachment of the primordial thyroid at this site before starting its caudal migration [8,26].…”

Section: The Issue Of Ectopic Thyroid Tissuementioning

confidence: 99%

Personalized Management of Malignant and Non-Malignant Ectopic Mediastinal Thyroid: A Proposed 10-Item Algorithm Approach

Carsote,

Ciobica,

Sima

et al. 2024

Cancers

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We aimed to analyze the management of the ectopic mediastinal thyroid (EMT) with respect to EMT-related cancer and non-malignant findings related to the pathological report, clinical presentation, imaging traits, endocrine profile, connective tissue to the cervical (eutopic) thyroid gland, biopsy or fine needle aspiration (FNA) results, surgical techniques and post-operatory outcome. This was a comprehensive review based on revising any type of freely PubMed-accessible English, full-length original papers including the keywords “ectopic thyroid” and “mediastinum” from inception until March 2024. We included 89 original articles that specified EMTs data. We classified them into four main groups: (I) studies/case series (n = 10; N = 36 EMT patients); (II) malignant EMTs (N = 22 subjects; except for one newborn with immature teratoma in the EMT, only adults were reported; mean age of 62.94 years; ranges: 34 to 90 years; female to male ratio of 0.9). Histological analysis in adults showed the following: papillary (N = 11/21); follicular variant of the papillary type (N = 2/21); Hürthle cell thyroid follicular malignancy (N = 1/21); poorly differentiated (N = 1/21); anaplastic (N = 2/21); medullary (N = 1/21); lymphoma (N = 2/21); and MALT (mucosa-associated lymphoid tissue) (N = 1/21); (III) benign EMTs with no thyroid anomalies (N = 37 subjects; mean age of 56.32 years; ranges: 30 to 80 years; female to male ratio of 1.8); (IV) benign EMTs with thyroid anomalies (N = 23; female to male ratio of 5.6; average age of 52.1 years). This panel involved clinical/subclinical hypothyroidism (iatrogenic, congenital, thyroiditis-induced, and transitory type upon EMT removal); thyrotoxicosis (including autonomous activity in EMTs that suppressed eutopic gland); autoimmune thyroiditis/Graves’s disease; nodules/multinodular goiter and cancer in eutopic thyroid or prior thyroidectomy (before EMT detection). We propose a 10-item algorithm that might help navigate through the EMT domain. To conclude, across this focused-sample analysis (to our knowledge, the largest of its kind) of EMTs, the EMT clinical index of suspicion remains low; a higher rate of cancer is reported than prior data (18.8%), incident imagery-based detection was found in 10–14% of the EMTs; surgery offered an overall good outcome. A wide range of imagery, biopsy/FNA and surgical procedures is part of an otherwise complex personalized management.

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“…Ectopic thyroid tissue is a rare condition, in about 90% of cases located in the lingual area. [ 1 ] The descent of the thyroid primordium from the foramen cecum of the tongue along the thyroglossal duct may explain the most frequent presence of ectopic tissue along the midline, from the base of the tongue to the mediastinum. [ 2 ] Graves' disease is the most common cause of thyrotoxicosis, with an annual incidence of 20–50 cases/100,000 persons.…”

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confidence: 99%

Usefulness of Hybrid Single-Photon Emission Computed Tomography/ Computed Tomography in a Case of Ectopic Thyroid Tissue in the Thyroglossal Duct Remnant

Calandri

Filippi

Alessandro

et al. 2021

Indian Journal of Nuclear Medicine

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Here, we report a case of a 54-year-old woman affected by thyrotoxicosis, with scintigraphic evidence of a diffuse hyperfunctioning goiter and a large ectopic thyroid tissue in the thyroglossal duct remnant. The latter was apparently more active than the two lobes at 99m Tc-pertechnetate scintigraphy, mimicking a condition of preexisting increased sensitivity to thyroid-stimulating hormone stimulation. On the other hand, single-photon emission computed tomography/computed tomography has proven to be a very useful tool in demonstrating this activity to be similar to the thyroid lobes and in defining extension and anatomical relationships of the mass.

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Multifocal ectopic thyroid tissues including breast: A case report

Cited by 4 publications

References 13 publications

Ectopic thyroid as multiple nodules in bilateral lung lobes: a case report

Ectopic thyroid as multiple nodules in bilateral lung lobes: a case report

Personalized Management of Malignant and Non-Malignant Ectopic Mediastinal Thyroid: A Proposed 10-Item Algorithm Approach

Usefulness of Hybrid Single-Photon Emission Computed Tomography/ Computed Tomography in a Case of Ectopic Thyroid Tissue in the Thyroglossal Duct Remnant

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