Multifocal Electroretinogram in Patients with Central Serous Chorioretinopathy

Suzuki, Keiko; Hasegawa, Shigeru; Usui, Tomoaki; Ichibe, Mikio; Takada, Ryozo; Takagi, Mineo; Abe, Haruki

doi:10.1016/s0021-5155(02)00477-x

Cited by 20 publications

(9 citation statements)

References 14 publications

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“…Hence, adjuvant therapies to RD surgery cannot be tested in the porcine model. After resolution of subretinal fluid in patients with CSCR, persistent abnormalities of the mfERG have been found [39,40]. An explanation for this discrepancy between human and porcine mfERG findings could be the difference in retinal signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

The effect of subretinal viscoelastics on the porcine retinal function

Sørensen

Ejstrup

Svahn

et al. 2011

Graefes Arch Clin Exp Ophthalmol

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The functional consequence of long-term retinal detachment in the porcine model is examined by multifocal electroretinography (mfERG). Retinal detachment (RD) in humans leaves permanent visual impairment, despite anatomical successful reattachment surgery. To improve treatment, adjuvant pharmaceutical therapy is needed, and can only be tested in a suitable animal model. The porcine model is promising and the mfERG is well validated in this model. RD was induced in 18 pigs by vitrectomy and healon injection of various concentrations. Preoperatively and 6 weeks postoperatively eight animals were examined by mfERG. The major component P1 was analyzed statistically. Indirect ophthalmoscopy and bilateral color fundus photography (FP) were performed. Selected animals underwent high-resolution optical coherence tomography (OCT). Examination by ophthalmoscopy and FP showed that the RDs remained detached for the 6 weeks of follow-up. The P1 amplitude of the mfERG did not differ significantly between the detached areas, the surrounding attached areas, and the healthy eye (p = 0.25). Similarly, P1 implicit time did not differ between the areas (p = 0.85). The lack of functional consequences of long-term RD makes the porcine model unsuitable for examining adjuvant pharmaceutical RD treatment. Future studies should focus on foveated primates.

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Section: Discussionmentioning

confidence: 99%

The effect of subretinal viscoelastics on the porcine retinal function

Sørensen

Ejstrup

Svahn

et al. 2011

Graefes Arch Clin Exp Ophthalmol

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“…219 mfERG amplitudes improve markedly after resolution of subretinal fluid, but do not return to normal levels. 38,210,211 …”

Section: Pathophysiologymentioning

confidence: 99%

Central Serous Chorioretinopathy: Update on Pathophysiology and Treatment

Nicholson

Noble

Forooghian

et al. 2013

Survey of Ophthalmology

562

573

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Recent technological advances have led to an improved understanding of central serous chorioretinopathy (CSC): new pathophysiological insights, new imaging techniques for diagnosis and management, and new treatments. The primary role of the choroid has become more widely accepted with widespread use of indocyanine green angiography. Optical coherence tomography (OCT), and particularly enhanced depth imaging OCT, demonstrate a thickened and engorged choroid. Adaptive optics, fundus autofluorescence, multifocal electroretinography, microperimetry, and contrast sensitivity testing reveal that patients with even a mild course suffer previously undetected anatomic and functional loss. While focal laser and photodynamic therapy are the current standard of care for persistent subretinal fluid in CSC, they are not appropriate in all cases, and the optimal timing of intervention remains unclear.

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“…In acute CSCR with decreased visual acuity, some visual disturbances determined by electrophysiological tests have been reported in previous studies [2, 3,20,21,22,23,24,25]. Some central visual functions do not seem to recover in all eyes after CSCR even if the visual acuity has returned to normal [3,4,5, 26].…”

Section: Discussionmentioning

confidence: 94%

Comparison of Achromatic and Blue-on-Yellow Perimetry in Patients with Resolved Central Serous Chorioretinopathy

Afrashi

Erakgün²,

Uzunel³

et al. 2005

Ophthalmologica

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Central serous chorioretinopathy (CSCR) is a disorder characterized by the serous detachment of the sensory retina in the posterior pole. Although CSCR usually resolves spontaneously, the patients may notice residual visual deficits, despite recovering normal visual acuity. The aim of this study is to compare the blue-on-yellow perimetric parameters with conventional automated perimetric parameters in the detection of visual deficits in patients with resolved CSCR. Eighteen patients who had spontaneous recovered from CSCR were enrolled this study. All subjects were examined twice with each type of perimetry. Wilcoxon test was used for statistical analysis. The achromatic perimetric mean deviation values were significantly higher in patients with CSCR than in the control group, while statistically a significant difference was determined for all of blue-on-yellow perimetric values. In conclusion the loss of central retinal sensitivity remains after resolution of the CSCR even if the visual acuity has recovered to normal. Blue-on-yellow perimetry is more sensitive than achromatic perimetry to reveal this central sensitivity loss.

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Multifocal Electroretinogram in Patients with Central Serous Chorioretinopathy

Cited by 20 publications

References 14 publications

The effect of subretinal viscoelastics on the porcine retinal function

The effect of subretinal viscoelastics on the porcine retinal function

Central Serous Chorioretinopathy: Update on Pathophysiology and Treatment

Comparison of Achromatic and Blue-on-Yellow Perimetry in Patients with Resolved Central Serous Chorioretinopathy

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