Multifocal electroretinography in patients with macular telangiectasia type 2

Goel, Neha; Kumari, Anjula; Kumar, Satish; Mehta, Aanchal

doi:10.1007/s10633-019-09746-y

Cited by 5 publications

(8 citation statements)

References 15 publications

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“…Thus, this study and those of other authors (Okada et al 2018;Goel et al 2020) have indicated localised inner retinal dysfunction in MacTel. In contrast, full-field ERGs in patients with MacTel are invariably normal.…”

Section: Discussionsupporting

confidence: 86%

“…Multifocal electroretinography (mfERG) provides objective functional measures of localised macular function facilitating structure‐function correlations. Data have been published that show alterations of some electrophysiological parameters in MacTel (Gass & Oyakawa 1982; Barthelmes et al 2007; Narayanan et al 2013; Ledolter et al 2018; Okada et al 2018; Goel et al 2020). A reduction in mfERG N1 and P1 amplitudes and increased peak times has been reported (Narayanan et al 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Further, a significant correlation was demonstrated between the size of the EZ disruption and P1 amplitude and the P1:N1 ratio of the central mfERG response (Okada et al 2018). A recent study showed mean P1 amplitudes were statistically significantly decreased in eyes with MacTel compared with controls in ring 1, suggesting localised central retinal dysfunction (Goel et al 2020).…”

Section: Introductionmentioning

confidence: 99%

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Macular Telangiectasia type 2: multimodal assessment of retinal function and microstructure

Ledolter

Ristl

Palmowski-Wolfe

et al. 2021

Acta Ophthalmologica

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To assess the impact of neurodegenerative morphologic alterations due to macular telangiectasia type 2 (MacTel) on microperimetry (MP) and multifocal electroretinography (mfERG). Methods: Thirty-five eyes of 18 patients with MacTel were examined using spectral domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF), mfERG and MP. Software was used to match SD-OCT B-scans with the corresponding retinal sensitivity map and multifocal electroretinograms (mfERGs), thus enabling direct structure/function correlation. Results: Loss of the ellipsoid zone (EZ) had the strongest negative association with retinal sensitivity (16.77 dB versus 4.58 dB, adj. p < 0.001) of all parameters examined, and a limited negative effect on mfERGs (0.32 SD versus À1.97 SD adj. p = 0.121). Ellipsoid zone (EZ) irregularity was associated with reduced MP values but preserved mfERGs. There was a significant association between areas of inner retinal hyporeflectivity and loss of MP sensitivity (adj. p < 0.001) but the reduction in sensitivity was less than in locations with EZ loss. Areas of mfERG abnormality showed similar sensitivity loss with either inner retinal hyporeflectivity or EZ loss (adj. p = 0.063). In areas with EZ loss alone, preservation of the external limiting membrane (ELM) was associated with higher MP values than in areas with additional ELM loss; the integrity of the ELM alone was not associated with changes either in MP or mfERG. Increased FAF was observed in 51% of eyes, mixed/reduced FAF in 40%, and no abnormality was detected in 9% of eyes. Conclusion:The data suggest both MP and mfERG to be useful non-invasive modalities for detecting localised macular dysfunction in MacTel. The findings suggest a different sensitivity of the two modalities to inner and outer retinal changes in macular function and are therefore complementary.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Macular Telangiectasia type 2: multimodal assessment of retinal function and microstructure

Ledolter

Ristl

Palmowski-Wolfe

et al. 2021

Acta Ophthalmologica

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“…Although they noted a signi cant and negative correlation between BCVA and P1 amplitude and implicit time, the positive correlation of CMT and P1 was not signi cant. 17 Narayanan et al stated there was a signi cant reduction in amplitudes as well as delay in implicit times of the waveforms in patients with type 2 Mac Tel in all the rings, compared to a matched normal population. The maximum reductions were seen in R1.…”

Section: Discussionmentioning

confidence: 98%

Multimodal characterization of macular telangiectasia type 2 and correlation with multifocal electroretinogram

Ayachit

Reddy

Joshi

2021

Preprint

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1. Purpose: To study the correlation of multimodal imaging in macular telangiectasia (Mac Tel) with foveal function on multifocal electroretinogram (mfERG)2. Methods: Eyes with non- proliferative Mac Tel diagnosed based on clinical examination, optical coherence tomography (OCT), autofluorescence (AF), fluorescein angiography (FA), OCT angiography (OCTA). Control group with normal eye exam included for multifocal electroretinogram.Staging of OCT, OCTA, AF and FA done in Mac Tel subjects. mfERG done in study subjects and controls. Correlation of imaging modalities and P1 amplitudes at fovea (ring 1) studied in terms of correlation co-efficient.3. Results: Twenty nine eyes of 16 patients of Mac Tel and 25 eyes of 19 controls were included. BCVA was 0.38 ± 0.266 in study eyes and 0 in control eyes. On OCT it was observed that 41.4% Mac Tel eyes (n = 12) belonged to stage 3, 37.9%(n = 11)) eyes belonged to stage 2 and 20.7% (n = 6) eyes belonged to stage 1. AF- Stage 3 comprised of 75.9% eyes (n = 22); 4 eyes belonged to stage 2 and 3 eyes to stage 1. On FA, 18 eyes belonged to stage 3 (62.1%); stage 2 was seen in 1 (3.4%) eye and stage 1 was seen in 10 (34.5%) eyes. There was decrease in P1 amplitudes from R1(p < 0.001), R2( 0.001), R3 (< 0.001) and R4 (0.001) in Mac Tel eyes compared to control eyes but not in R5 (p 0.785). SD- OCT had positive correlation with FAF (CC 0.747,p < 0.001) FFA (CC 0.775, p < 0.001) and R1P1 (CC 0.682, p < 0.001). With OCTA there was no significant correlation (CC 0.318, p 0.093). There was positive and significant correlation of OCT (0.682,<0.001), OCTA (0.379,p 0.042) AF ( 0.635, p < 0.001) and FA (0.495, p < 0.006) with R1P1.4. Conclusions: Existing multimodal imaging systems can be reliable indicators of foveal function as on mfERG.

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“… 5 , 6 , 26 We cannot, however, completely exclude some contributions of d3 mechanism loss, which would be predicted based on electrophysiological observations in MacTel. 27 – 30 It will be noted that increment threshold testing could also be used to determine the contribution of postreceptoral losses to threshold elevation. 23 …”

Section: Discussionmentioning

confidence: 99%

Impairments in Cone Pigment Regeneration and Absolute Threshold in Macular Telangiectasia Type 2

Simunovic

Hess

Gillies

2021

Retina

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Multifocal electroretinography in patients with macular telangiectasia type 2

Cited by 5 publications

References 15 publications

Macular Telangiectasia type 2: multimodal assessment of retinal function and microstructure

Macular Telangiectasia type 2: multimodal assessment of retinal function and microstructure

Multimodal characterization of macular telangiectasia type 2 and correlation with multifocal electroretinogram

Impairments in Cone Pigment Regeneration and Absolute Threshold in Macular Telangiectasia Type 2

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