Multifocal Granulomatous Jejunitis Associated with an Argyrophilic Gram-Positive Segmented Filamentous Bacterium in a Holstein Cow

Ibaraki, Yoshihiro; Shibahara, Tomoyuki; Kobayashi, Hideki; Ito, Naofumi; Shinozuka, Yasunori; Kasuya, Kazuhiko; Murakoshi, Naoko; Chikuba, Takumi; Kubo, Michinori

doi:10.1016/j.jcpa.2010.12.007

Cited by 3 publications

(2 citation statements)

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“… 104 ) Although we tried in vain to find SFB 16S rRNA gene sequence in the intestinal contents of humanized ex-germ free mice associated with microbiota of human baby feces (data not shown), there are some reports suggesting the presence of SFB in humans, according to light micrography and partial 16S rRNA gene sequences. 38 , 105 , 106 ) Moreover, due to the presence of SFB or the morphologically similar microbes in a wide range of mammals such as rhesus monkey, 38 ) crab-eating monkey, 38 , 94 ) pig, 107 , 108 ) dog, 38 , 109 , 110 ) cat, 38 ) cow, 111 ) calf, 112 ) horse, 113 ) and rabbit, 85 ) there is no reason to exclude human from this group at present. Although the functions of SFB are unknown at all except rodents, SFB or SFB equivalent microbes may start to colonize or transiently colonize the human small intestine around the weaning period according to the observations in the animals mentioned above.…”

Section: Discussionmentioning

confidence: 99%

Use of gnotobiotic mice to identify and characterize key microbes responsible for the development of the intestinal immune system

Umesaki

2014

Proceedings of the Japan Academy. Ser. B: Physical and Biologic

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Symbiosis between intestinal microbiota and the host animal plays an important role in the homeostasis of host physiology. Since the first production of germ-free rodents in 1945, it has become increasingly clear that the intestinal immune system and the biochemical characteristics of epithelial cells differ greatly between conventional and germ-free rodents. However, questions remain about the types of microbes involved and the precise mechanism by which these microbes affect the host physiology. Here, we review experiments designed to answer these questions with the use of gnotobiotic mice. We have determined suitable biochemical and immunological markers for monitoring microbial effects in these mice. Using these markers, we have found clear differences in epithelial cell glycolipid biosynthesis and intraepithelial lymphocyte dynamics between germ-free and conventional mice. Furthermore, we have identified a key microbe that activates the mucosal immune system in the small intestine. This indigenous bacteria, called segmented filamentous bacteria, is a key symbiont in the host-microbiota interplay, including Th17 cell-inducing activity.

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Section: Discussionmentioning

confidence: 99%

Use of gnotobiotic mice to identify and characterize key microbes responsible for the development of the intestinal immune system

Umesaki

2014

Proceedings of the Japan Academy. Ser. B: Physical and Biologic

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“…1 The clinical and laboratory findings of cattle with intussusception have been described in textbooks, 1 , 2 , 3 , 4 continuing education materials 5 and publications that involved 15, 6 20 8 38 and 57 cases, 2 21 respectively. Numerous case reports of cattle with intussusception have been published, 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 while older studies (1917–1964) have been reviewed. 21 Several studies involved percutaneous ultrasonographic imaging of intussusception via the right flank in cows, 17 , 22 , 23 , 24 , 25 , 26 and one study used transrectal imaging.…”

Section: Introductionmentioning

confidence: 99%

A retrospective review of small intestinal intussusception in 126 cattle in Switzerland

Braun

Gerspach

Volz

et al. 2023

Veterinary Record Open

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Background Intussusception is a form of ileus of the intestines in which an oral intestinal segment slides into the adjacent aboral intestinal segment, causing obstruction of the bowel. Methods We analysed the medical records of 126 cattle with intussusception of the small intestine. Results Demeanour and appetite were abnormal in 123 cattle. Non‐specific signs of pain occurred in 26.2%, signs of visceral pain in 46.8% and signs of parietal pain in 56.4%. Intestinal motility was decreased or absent in 93.7% of the cattle. The most common findings of transrectal palpation were rumen dilation (37.3%) and dilated small intestines (24.6%). In 96% of the cattle, the rectum was empty or contained little faeces. The principal laboratory findings were hypokalaemia (89.6%), hypocalcaemia (76.5%), base excess (72.9%), hypochloraemia (71.8%), azotaemia (62.1%) and haemoconcentration (61.1%). The main ultrasonographic findings were reduced or absent intestinal motility (98.2%) and dilated small intestines (96.0%). A diagnosis of ileus was made in 87.8% and a diagnosis of ileus attributable to intussusception was made in another 9.8%. Right‐flank laparotomy was carried out in 114 cattle. Fifty‐six (44.4%) cows were discharged. Conclusions Clinical findings of intussusception in cattle are often non‐specific. Ultrasonography may be required to diagnose ileus.

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Segmented Filamentous Bacteria attached to the Epithelial Cells of the Ileum in Piglets with Diarrhea

Yaguchi

Shibahara

Kusuhara

et al. 2015

J.Jpn.Vet.Med.Assoc.

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Multifocal Granulomatous Jejunitis Associated with an Argyrophilic Gram-Positive Segmented Filamentous Bacterium in a Holstein Cow

Cited by 3 publications

References 11 publications

Use of gnotobiotic mice to identify and characterize key microbes responsible for the development of the intestinal immune system

Use of gnotobiotic mice to identify and characterize key microbes responsible for the development of the intestinal immune system

A retrospective review of small intestinal intussusception in 126 cattle in Switzerland

Segmented Filamentous Bacteria attached to the Epithelial Cells of the Ileum in Piglets with Diarrhea

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