Multifocal Nodular Oncocytic Hyperplasia in Parotid Gland

Goyal, Rajiva; Ahuja, Arvind; Gupta, Neha; Singh, Gurshawn; Vaiphei, Kim

doi:10.1159/000325811

Cited by 17 publications

(10 citation statements)

References 6 publications

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“…Although there was some variability between specimens, we identified a characteristic pattern of paucicellular smears comprised of small groups of oncocytic cells in the majority of FNA specimens of oncocytosis. These findings are similar to those noted in previous case reports of oncocytosis cytology . Although the features described herein are not entirely specific, they should both support the inclusion of oncocytosis in the preoperative differential diagnosis and allow oncocytosis to be favored over other salivary gland lesions with oncocytic features in the appropriate clinical and radiographic setting.…”

Section: Discussionsupporting

confidence: 89%

“…These findings are similar to those noted in previous case reports of oncocytosis cytology. [7][8][9] Although the features described herein are not entirely specific, they should both support the inclusion of oncocytosis in the preoperative differential diagnosis and allow oncocytosis to be favored over other salivary gland lesions with oncocytic features in the appropriate clinical and radiographic setting.…”

Section: Cancer Cytopathologymentioning

confidence: 74%

“…Unfortunately, there are many benign and malignant salivary conditions that enter the differential diagnosis of oncocytosis, including Warthin tumor, oncocytoma, papillary oncocytic cystadenoma/cystadenocarcinoma, salivary duct carcinoma, acinic cell carcinoma, mammary analog secretory carcinoma (MASC), and oncocytic mucoepidermoid carcinoma. Moreover, only a few reports previously have described the cytologic characteristics of oncocytosis cases that might help facilitate this distinction . Herein, we evaluated FNA findings in what to our knowledge is the largest series of oncocytosis cases reported to date in the hopes of allowing the confident preoperative diagnosis of this condition.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, only a few reports previously have described the cytologic characteristics of oncocytosis cases that might help facilitate this distinction. [7][8][9] Herein, we evaluated FNA findings in what to our knowledge is the largest series of oncocytosis cases reported to date in the hopes of allowing the confident preoperative diagnosis of this condition.…”

Section: Introductionmentioning

confidence: 99%

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Nodular oncocytic hyperplasia: Can cytomorphology allow for the preoperative diagnosis of a nonneoplastic salivary disease?

Rooper

Önenerk

Siddiqui

et al. 2017

Cancer Cytopathology

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Although oncocytosis demonstrates some overlap with Warthin tumor and oncocytoma, it lacks the diagnostic findings specific to oncocytic salivary gland malignancies such as salivary duct carcinoma, acinic cell carcinoma, mammary analog secretory carcinoma, and mucoepidermoid carcinoma. Despite current limitations in the understanding of oncocytic salivary gland lesions, the presence of a paucicellular specimen comprised of small groups of oncocytic cells should raise the possibility of oncocytosis in the differential diagnosis and can favor it in elderly patients with multiple salivary nodules. Cancer Cytopathol 2017;125:627-34. © 2017 American Cancer Society.

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Section: Discussionsupporting

confidence: 89%

Section: Cancer Cytopathologymentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nodular oncocytic hyperplasia: Can cytomorphology allow for the preoperative diagnosis of a nonneoplastic salivary disease?

Rooper

Önenerk

Siddiqui

et al. 2017

Cancer Cytopathology

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“…Oncocytosis is a rare non-neoplastic lesion that is classified as diffuse oncocytosis and multifocal adenomatous oncocytic hyperplasia (MAOH) [ 2 ]; it comprises approximately 0.1% of salivary gland lesions [ 3 , 4 ]. The correct cytological diagnosis of oncocytosis can be difficult because oncocytes are seen in a variety of other salivary gland lesions, and it is usually diagnosed by histological examination [ 5 , 6 , 7 , 8 ]. Here, we report a case of MAOH of the parotid gland.…”

Section: Introductionmentioning

confidence: 99%

Multifocal Adenomatous Oncocytic Hyperplasia of the Parotid Gland

et al. 2014

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Multifocal adenomatous oncocytic hyperplasia (MAOH) is a non-neoplastic lesion that is classified as oncocytosis. MAOH is a rare entity of the parotid gland and accounts for approximately 0.1% of salivary gland lesions. Here, we report a case of MAOH of the parotid gland. The patient was a 71-year-old woman who presented with discomfort at the left side of her neck. Fine-needle aspiration cytology of the parotid gland revealed a loose sheet-like cluster of round to polygonal cells with granular cytoplasm against a hemorrhagic background. The cells had round to oval, centrally located nuclei with granular chromatin and without distinct nucleoli. Histologically, the lesion was formed of many variable-sized nodules, comprising oncocyte-like cells with small round nuclei and eosinophilic granular cytoplasm that was positive for mitochondrial antibodies. The diagnosis of MAOH is difficult to make by cytology alone, because the findings overlap with those of other oncocytic lesions. In particular, the cytological findings of MAOH have not been sufficiently reported to date. A correlation of cytology and histology was expected.

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Salivary Glands, Head and Neck

Spieler

Rössle²

2012

Essentials of Diagnostic Pathology

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Multifocal Nodular Oncocytic Hyperplasia in Parotid Gland

Cited by 17 publications

References 6 publications

Nodular oncocytic hyperplasia: Can cytomorphology allow for the preoperative diagnosis of a nonneoplastic salivary disease?

Nodular oncocytic hyperplasia: Can cytomorphology allow for the preoperative diagnosis of a nonneoplastic salivary disease?

Multifocal Adenomatous Oncocytic Hyperplasia of the Parotid Gland

Salivary Glands, Head and Neck

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