Multifunctional Au Modified Ti<sub>3</sub>C<sub>2</sub>-MXene for Photothermal/Enzyme Dynamic/Immune Synergistic Therapy

Chang, Xin; Wu, Qiong; Wu, Yue; Xi, Xi; Cao, Jingrui; Chu, Hongyu; Liu, Qihui; Li, Yuanyuan; Wen, Wu; Fang, Xuedong; Chen, Fangfang

doi:10.1021/acs.nanolett.2c03260

Cited by 50 publications

(24 citation statements)

References 44 publications

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“…The combination of targeted chemotherapy (doxorubicin) with photothermal therapy using these hydrogels could reduce the recurrence of tumors to ~ 33.3%, compared to the examined doxorubicin-loaded hydrogels without near-infrared irradiation (~ 66.7%), local administration of free doxorubicin (~ 66.7%), and hydrogels with near-infrared irradiation (~ 100%) [116]. The results proposed the high efficiency of hydrogels in the recurrence inhibition of breast cancer, showing more efficient cancer therapy than in the metalbased nanomaterials [117].…”

Section: Cancer Therapeuticsmentioning

confidence: 89%

Self-Healing MXene- and Graphene-Based Composites: Properties and Applications

et al. 2023

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Today, self-healing graphene- and MXene-based composites have attracted researchers due to the increase in durability as well as the cost reduction in long-time applications. Different studies have focused on designing novel self-healing graphene- and MXene-based composites with enhanced sensitivity, stretchability, and flexibility as well as improved electrical conductivity, healing efficacy, mechanical properties, and energy conversion efficacy. These composites with self-healing properties can be employed in the field of wearable sensors, supercapacitors, anticorrosive coatings, electromagnetic interference shielding, electronic-skin, soft robotics, etc. However, it appears that more explorations are still needed to achieve composites with excellent arbitrary shape adaptability, suitable adhesiveness, ideal durability, high stretchability, immediate self-healing responsibility, and outstanding electromagnetic features. Besides, optimizing reaction/synthesis conditions and finding suitable strategies for functionalization/modification are crucial aspects that should be comprehensively investigated. MXenes and graphene exhibited superior electrochemical properties with abundant surface terminations and great surface area, which are important to evolve biomedical and sensing applications. However, flexibility and stretchability are important criteria that need to be improved for their future applications. Herein, the most recent advancements pertaining to the applications and properties of self-healing graphene- and MXene-based composites are deliberated, focusing on crucial challenges and future perspectives.

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Section: Cancer Therapeuticsmentioning

confidence: 89%

Self-Healing MXene- and Graphene-Based Composites: Properties and Applications

et al. 2023

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“…1f, Additional file 1: Fig. S6) (Chang et al 2022). Interestingly, the UVvis absorption of Ti 3 C 2 /Apt-M at 808 nm did not change significantly compared to Ti 3 C 2 (Additional file 1: Fig.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

Aptamer modified Ti3C2 nanosheets application in smart targeted photothermal therapy for cancer

et al. 2023

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Background Ti3C2 is a type of transition metal carbides and nitrides (MXenes) with high light-to-heat conversion efficiency property, which has been widely used in cancer treatment recently. In fact, active targeting delivery of MXenes nanomaterials with targeting molecule could enhance the therapeutic efficacy. However, targeted therapy of MXenes has not been further studied in the past. Aptamers (Apt) with excellent affinity and high specificity properties have been widely used as targeting tools. Predictably, the incorporation of Apt into Ti3C2 nanomaterials will offer an unprecedented opportunity in the research fields of cancer targeted therapy. Results Transmembrane glycoprotein mucin 1 (MUC1) is overexpressed on the surface of MCF-7 cells, and MUC1 Apt (Apt-M) could target MCF-7 cells with high affinity and specificity. Here, a smart targeting nanotherapeutic system Ti3C2/Apt-M was fabricated, which could specifically recognize and enter in MCF-7 cells. Benefitting from the desirable targeted performance of Apt-M, MCF-7 cells completed the ingestion process of Ti3C2/Apt-Mf nanosheets within 4 h, and Apt-M facilitated the entry of the Ti3C2/Apt-Mf nanosheets into MCF-7 cells. Besides, Ti3C2/Apt-M nanosheets exhibited the potential as an outstanding photothermal agent (PTA) because of the photothermal performance inherited from wrapped Ti3C2 nanosheets. As demonstrated, upon 808 nm laser irradiation, the Ti3C2/Apt-M nanotherapeutic system displayed a satisfactory antitumor effect by targeted photothermal therapy both in vitro and in vivo. Conclusion This study provides a new idea for the development of MXenes nanotherapeutic system with high active targeting performance. Graphical Abstract

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“… 52 In this context, MXenes have attracted increasing attention in stem cell engineering, 53 – 55 regenerative medicine, 56 – 59 artificial organs, 56 and immunomodulation. 60 – 62 …”

Section: Tissue Engineering and Immunomodulation With Mxenesmentioning

confidence: 99%

Latest advances on MXenes in biomedical research and health care

Garg

Vitale

2023

MRS Bulletin

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The unique combination of physical and chemical properties of MXenes has propelled a growing number of applications in biomedicine and healthcare. The expanding library of MXenes with tunable properties is paving the way for high-performance, application-specific MXene-based sensing and therapeutic platforms. In this article, we highlight the emerging biomedical applications of MXenes with specific emphasis on bioelectronics, biosensors, tissue engineering, and therapeutics. We present examples of MXenes and their composites enabling novel technological platforms and therapeutic strategies, and elucidate potential avenues for further developments. Finally, we discuss the materials, manufacturing, and regulatory challenges that need to be synergistically addressed for the clinical translation of MXene-based biomedical technologies. Graphical abstract

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Multifunctional Au Modified Ti₃C₂-MXene for Photothermal/Enzyme Dynamic/Immune Synergistic Therapy

Cited by 50 publications

References 44 publications

Self-Healing MXene- and Graphene-Based Composites: Properties and Applications

Self-Healing MXene- and Graphene-Based Composites: Properties and Applications

Aptamer modified Ti3C2 nanosheets application in smart targeted photothermal therapy for cancer

Latest advances on MXenes in biomedical research and health care

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Multifunctional Au Modified Ti3C2-MXene for Photothermal/Enzyme Dynamic/Immune Synergistic Therapy

Cited by 50 publications

References 44 publications

Self-Healing MXene- and Graphene-Based Composites: Properties and Applications

Self-Healing MXene- and Graphene-Based Composites: Properties and Applications

Aptamer modified Ti3C2 nanosheets application in smart targeted photothermal therapy for cancer

Latest advances on MXenes in biomedical research and health care

Contact Info

Product

Resources

About

Multifunctional Au Modified Ti₃C₂-MXene for Photothermal/Enzyme Dynamic/Immune Synergistic Therapy