Multifunctional biodegradable nanoplatform based on oxaliplatin prodrug cross-linked mesoporous polydopamine for enhancing cancer synergetic therapy

Sun, Peng; Li, Zimu; Zhang, Dan; Zeng, Wenfeng; Zheng, Yi; Mei, Lin; Chen, Hongzhong; Gao, Nansha; Zeng, Xiaowei

doi:10.1016/j.cclet.2023.108346

Cited by 21 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several reports are on the antitumor effects of BP-based drug delivery systems. − However, these nanocarriers are primarily loaded with small-molecule drugs and nucleotides instead of bioactive macromolecules. In addition, polydopamine is most widely used for drug delivery applications, including photothermal and targeted therapies. − Nevertheless, immunotherapy and PTT can synergistically inhibit tumor cells using multiple mechanisms, such as improving ferroptosis for synergistic photothermal-IDO immunotherapy. , …”

Section: Introductionmentioning

confidence: 99%

Cordyceps sinensis Polysaccharide Loaded on Black Phosphorus for Synergistic Immunotherapy and Photothermal Therapy of Cancer

Wang,

Chen,

et al. 2024

ACS Appl. Nano Mater.

Self Cite

View full text Add to dashboard Cite

Cordyceps sinensis is a valuable Chinese medicine, possessing multiple bioactive compounds with diverse pharmacological effects. The extracts of C. sinensis, especially the polysaccharide fraction, can suppress the proliferation of different tumor cells, induce apoptosis, and stimulate antitumor immune responses. However, C. sinensis polysaccharides (CSP) have yet to be characterized, with a rare reporting of their effective doses. Immunotherapy depends on harnessing the inherent ability of the immune system to recognize and eliminate tumor cells. Polarizing the anti-inflammatory M2 tumor-associated macrophages (TAMs) to the pro-inflammatory M1 phenotype is an effective antitumor immunotherapy strategy. We designed a drug delivery system with black phosphorus (BP) nanosheets loaded with CSP for synergistic antitumor photothermal therapy (PTT) and immunotherapy. The BP/CSP@PDA−PEG-FA nanoparticles (NPs) enhanced the polarization of M2 macrophages to the M1 phenotype in vitro and in vivo. Moreover, the NPs inhibited the growth of 4T1 xenografts upon near-infrared (NIR) laser stimulation by causing photothermal ablation of tumor cells and promoting T cellmediated antitumor immune responses. Therefore, BP/CSP@PDA−PEG-FA NPs are a promising platform for combined PTT and immunotherapy for breast tumors.

show abstract

Section: Introductionmentioning

confidence: 99%

Cordyceps sinensis Polysaccharide Loaded on Black Phosphorus for Synergistic Immunotherapy and Photothermal Therapy of Cancer

Wang,

Chen,

et al. 2024

ACS Appl. Nano Mater.

Self Cite

View full text Add to dashboard Cite

show abstract

“…PDA can be immobilized onto various solid substrates, such as mesoporous silica, iron nanoparticles, oxaliplatin, etc., by forming an adhesion layer under slightly alkaline conditions. At the same time, polydopamine itself has pH-sensitive properties that allow it to release the encapsulated drug in acidic environments such as wounds. − Thus, PDA often participates in the construction of antibacterial and drug-carrier materials.…”

Section: Introductionmentioning

confidence: 99%

MgO@polydopamine Nanoparticle-Loaded Photothermal Microneedle Patches Combined with Chitosan Gel Dressings for the Treatment of Infectious Wounds

Zheng,

Xie,

Yao

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

As for wound drug delivery, microneedles (MNs) have attracted wide attention. However, while effective at increasing the depth of drug delivery, traditional MNs often have limited drug loads and have difficulty penetrating scabs on wounds. Herein, we develop a drug delivery system combining MgO@ polydopamine (MgO@PDA) nanoparticle-loaded photothermal MN patches and chitosan (CS) gel to inhibit the formation of scabs and deliver sufficient drugs into deep tissue. When inserted into the wound, the MN system can keep the wound bed moist and weakly acidic to inhibit the formation of scabs and accelerate wound closure. The released MgO@PDA nanoparticles from both the tips and the backing layer, which immensely increase the drug load, continuously release Mg 2+ in the moist, weakly acidic wound bed, promoting tissue migration and the formation of microvessels. MgO@PDA nanoparticles show excellent antibacterial activity under near-infrared irradiation synergized with the CS gel, and the PDA coating can also overcome the adverse effects of oxidative stress. Through in vitro and in vivo experiments, the MN system showed remarkable antibacterial, antioxidant, anti-inflammatory, and pro-angiogenic effects, indicating its potential in the treatment of infectious wounds.

show abstract

“…Cancer is one of the diseases with the highest mortality rate in the world due to challenges in early detection, rapid metastasis, and severe side effects. , Nanomedicine has revolutionized cancer treatment by offering novel strategies for drug delivery, diagnosis, and therapy monitoring, − with advantages of improving curative effect, targeting desirable sites, and reducing side effects. − With the recent advancements in nanomaterial development, carbon dots (CDs) have emerged as a new class of fluorescent nanomaterials, which possess excellent fluorescence properties and the ability to simultaneously carry multiple drugs through covalent bonds, owing to their diverse surface functional groups such as amino, carboxyl, and hydroxyl groups. , In comparison to traditional semiconductor quantum dots, CDs exhibit superior biocompatibility, low toxicity, minimal environment impact, abundant raw material sources, and cost-effective preparation methods . Furthermore, CDs offer several advantages, including resistance to fluorescence quenching, ease of surface modification, and stable fluorescence performance, making them widely applicable in biological imaging and drug delivery. − …”

Section: Introductionmentioning

confidence: 99%

Investigation of Anticancer Therapy Using pH-Sensitive Carbon Dots-Functionalized Doxorubicin in Cubosomes

Xie,

Wang,

et al. 2024

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Cancer remains a highly lethal disease due to its elusive early detection, rapid spread, and significant side effects. Nanomedicine has emerged as a promising platform for drug delivery, diagnosis, and treatment monitoring. In particular, carbon dots (CDs), a type of fluorescent nanomaterial, offer excellent fluorescence properties and the ability to carry multiple drugs simultaneously through covalent bonding. In this work, CDs with carbonyl groups on the surface were prepared by aldol condensation and reacted with amine groups in the structure of doxorubicin (DOX) through Schiff base reaction to generate pH-responsive CDs-DOX. On the other hand, cubosomes with three-dimensional lattice structures formed by lipid bilayers have advantageous capabilities of encapsulating various hydrophilic, amphiphilic, and hydrophobic substances. The pH-responsive CDs-DOX are subsequently loaded into cubosomes to form an anticancer therapeutic nanosystem,

show abstract

Multifunctional biodegradable nanoplatform based on oxaliplatin prodrug cross-linked mesoporous polydopamine for enhancing cancer synergetic therapy

Cited by 21 publications

References 39 publications

Cordyceps sinensis Polysaccharide Loaded on Black Phosphorus for Synergistic Immunotherapy and Photothermal Therapy of Cancer

Cordyceps sinensis Polysaccharide Loaded on Black Phosphorus for Synergistic Immunotherapy and Photothermal Therapy of Cancer

MgO@polydopamine Nanoparticle-Loaded Photothermal Microneedle Patches Combined with Chitosan Gel Dressings for the Treatment of Infectious Wounds

Investigation of Anticancer Therapy Using pH-Sensitive Carbon Dots-Functionalized Doxorubicin in Cubosomes

Contact Info

Product

Resources

About