Multifunctional Carbon–Silica Nanocapsules with Gold Core for Synergistic Photothermal and Chemo‐Cancer Therapy under the Guidance of Bimodal Imaging

Abstract

Carbon‐based nanomaterials have been developed for photothermal cancer therapy, but it is still a great challenge to fabricate their multifunctional counterparts with facile methods, good biocompatibility and dispersity, and high efficiency for cancer theranostics. In this work, an alternative multifunctional nanoplatform is developed based on carbon–silica nanocapsules with gold nanoparticle in the cavity (Au@CSN) for cancer theranostics. The encapsulated chemodrug doxorubicin can be released from the Au@CSN with mesoporous and hollow structure in a near‐infrared light and pH stimuli‐responsive manner, facilitating spatiotemporal therapy to decrease off‐target toxicity. The nanocapsules with efficient photothermal conversion and excellent biocompatibility achieve a synergistic effect of photothermal and chemotherapy. Furthermore, the nanocapsules can act as a multimodal imaging agent of computed tomography and photoacoustic tomography imaging for guiding the therapy. This new design platform can provide a promising strategy for precise cancer theranostics.

Boosting Non‐Radiative Decay to Do Useful Work: Development of a Multi‐Modality Theranostic System from an AIEgen

“…Figures 3a and S10 show the photothermal conversion behavior of TFM NPs in an aqueous suspension with different concentrations under a6 33 nm laser with ap ower density of 0.5 Wcm À2 .T he temperature of the TFM NP dispersion was rapidly raised at the initial stage by using 3mgmL À1 of TFM NPs,increasing from 24.4 to 49.1 8 8Cupon 120 so fl aser irradiation, and reaching ap lateau at 65.3 8 8C after 10 min (Figure 3a). Thep hotothermal conversion efficiency (h)ofTFM NPs was calculated to be as high as 51.2 % ( Figure S11), [28] which is higher than the great majority of previously reported photothermal agents including small molecules, [20] polymers, [29] and inorganic materials, [30] revealing an excellent photothermal conversion performance of TFM NPs.Asdisplayed in Figures 3band S12, an obvious PA signal of TFM NPs dispersion was detected, and the PA intensity increased significantly along with the enhancement of the TFM NP concentration ranging from 0to10mgmL À1 , showing agood linear relationship (Figure 3b). Moreover,the PA intensity of the TFM NPs was lower than that of the TFM solution in THF ( Figure S13), perhaps initiated by the partially restricted molecular rotations,w hich is consistent with the MD simulation results.…”

pH‐Responsive PEG–Doxorubicin‐Encapsulated Aza‐BODIPY Nanotheranostic Agent for Imaging‐Guided Synergistic Cancer Therapy

“…PTT relies on photo‐induced heating to kill cancer cells, and has also attracted researchers' attention for its low side effects and relatively good antitumor efficacy . However, the intrinsic drawback of PTT is that remnant tumor cells may rapidly develop heat‐resisting capability . To overcome this limitation, the synergistic therapy combining PTT and PDT in one system is highly promising …”

Mn²⁺-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy

“…4 For example, chemotherapy has been combined with radiation therapy, 5 gene therapy, 6 magnetic hyperthermia therapy, 7 photothermal or photodynamic tumor therapy. 8,9 Photothermal therapy (PTT) is based on photothermal agents that strongly absorb near-infrared (NIR) light and convert it into cytotoxic heat for tumor treatment, such as indocyanine green, 10 gold nanomaterials 11 or carbon spheres, 12 PTT has been demonstrated as a noninvasive, harmless and highly efficient therapeutic strategy. Due to the limitation of radiant power and penetration depth of NIR light, PTT is often hard to kill tumors completely and might result in a recurrence of tumor growth.…”