Multifunctional chitin-based hollow nerve conduit for peripheral nerve regeneration and neuroma inhibition

Yang, Xiaqing; Huang, Lin; Yi, Xinzeyu; Huang, Siyuan; Duan, Bo; Yu, Aixi

doi:10.1016/j.carbpol.2022.119443

Cited by 17 publications

(18 citation statements)

References 53 publications

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“…A PDA-modified Chi conduit containing MSC-derived exosomes was found to augment neurite growth in the dorsal root ganglia of rats with sciatic nerve defects (Figure 6D). The antiinflammatory activity of PDA was also illustrated in a study conducted by Yang et al (2022) that modified a Chi-based nerve guidance conduit and showed its ability to inhibit neuromas during nerve regeneration. In addition, PDA promoted cell viability and protuberance expansion.…”

Section: Nerve Regenerationmentioning

confidence: 93%

A critical review on polydopamine surface-modified scaffolds in musculoskeletal regeneration

Tolabi

Bakhtiary

Sayadi

et al. 2022

Front. Bioeng. Biotechnol.

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Increasing concern about age-related diseases, particularly musculoskeletal injuries and orthopedic conditions, highlights the need for strategies such as tissue engineering to address them. Surface modification has been developed to create pro-healing interfaces, personalize scaffolds and provide novel medicines. Polydopamine, a mussel-inspired adhesive polymer with highly reactive functional groups that adhere to nearly all substrates, has gained attention in surface modification strategies for biomaterials. Polydopamine was primarily developed to modify surfaces, but its effectiveness has opened up promising approaches for further applications in bioengineering as carriers and nanoparticles. This review focuses on the recent discoveries of the role of polydopamine as a surface coating material, with focus on the properties that make it suitable for tackling musculoskeletal disorders. We report the evolution of using it in research, and discuss papers involving the progress of this field. The current research on the role of polydopamine in bone, cartilage, muscle, nerve, and tendon regeneration is discussed, thus giving comprehensive overview about the function of polydopamine both in-vitro and in-vivo. Finally, the report concludes presenting the critical challenges that must be addressed for the clinical translation of this biomaterial while exploring future perspectives and research opportunities in this area.

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Section: Nerve Regenerationmentioning

confidence: 93%

A critical review on polydopamine surface-modified scaffolds in musculoskeletal regeneration

Tolabi

Bakhtiary

Sayadi

et al. 2022

Front. Bioeng. Biotechnol.

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“…In recent years, many researchers have been committed to replace promising alternative biomaterials to autologous or allogeneic nerve transplantation, and simulate the macro or micro ring structure of peripheral nerves to improve the therapeutic effect and inhibit the occurrence of neuroma ( 25 , 26 ). Yang et al ( 27 ) designed a biodegradable cannula based on chitin for peripheral nerve injury in long-segment defects. The hollow cannula was prepared through chitin dissolution, molding, and regeneration, and then the hollow cannula was immersed in the anti-inflammatory dopamine solution ( Figure 3A ).…”

Section: Emerging Methods For Treatment Of Traumatic Neuromamentioning

confidence: 99%

“… (A) Schematic diagram of nerve scaffold synthesis reprinted (adapted) with permission from ( 27 ), Copyright (2022) Elsevier. (B) Schematic of PRGD/PDLLA conduit in preventing traumatic neuroma reprinted (adapted) with permission from ( 28 ), Copyright (2018) Wiley.…”

Section: Emerging Methods For Treatment Of Traumatic Neuromamentioning

confidence: 99%

New techniques and methods for prevention and treatment of symptomatic traumatic neuroma: A systematic review

Zhou

Huo²,

Zhang³

et al. 2023

Front. Neurol.

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Generally, axons located at the central end of the nerve system will sprout after injury. Once these sprouts cannot reach the distal end of the severed nerve, they will form a traumatic neuroma. Traumatic neuromas bring a series of complex symptoms to patients, such as neuropathic pain, skin abnormalities, skeletal abnormalities, hearing loss, and visceral damage. To date, the most promising and practical clinical treatments are drug induction and surgery, but both have their limitations. Therefore, it will be the mainstream trend to explore new methods to prevent and treat traumatic neuroma by regulating and remodeling the microenvironment of nerve injury. This work first summarized the pathogenesis of traumatic neuroma. Additionally, the standard methods of prevention and treatment on traumatic neuroma were analyzed. We focused on three essential parts of advanced functional biomaterial therapy, stem cell therapy, and human-computer interface therapy to provide the availability and value of preventing and treating a traumatic neuroma. Finally, the revolutionary development of the prevention and treatment on traumatic neuroma has been prospected. How to transform the existing advanced functional materials, stem cells, and artificial intelligence robots into clinical practical technical means as soon as possible for high-quality nerve repair and prevention of neuroma was further discussed.

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“…Other natural materials, including native fibrin ( Du et al, 2017 ; Wang et al, 2018 ; Razavi et al, 2021 ), collagen ( Saeki et al, 2018 ; Yao et al, 2018 ; He et al, 2021 ; Wang et al, 2021 ; Zheng et al, 2021 ), keratin ( Apel et al, 2008 ; Lin et al, 2012 ; Pace et al, 2014 ), alginate ( Lin et al, 2017 ; Rahmati et al, 2021 ; Abdelbasset et al, 2022 ), chitin ( Bak et al, 2017 ; Lu C. F. et al, 2021 ; Yang et al, 2022b ), chitosan ( Li et al, 2018 ; Vishnoi et al, 2019 ), and silk fibroin ( Carvalho et al, 2021 ; Kim et al, 2021 ; Zhao et al, 2020), as well as extracellular matrix (ECM) ( Li T. et al, 2021 ; Kong et al, 2021 ; Kong et al, 2022 ), have shown great potential in treating long gap nerve defects. For instance, Wang et al prepared a nerve catheter using chitosan/chitin to achieve excellent angiogenesis in nerve regeneration process for successfully repairing the 10 mm sciatic nerve defect in rats ( Wang et al, 2016 ).…”

Section: Research Progress Of Peripheral Nerve Graftsmentioning

confidence: 99%

The success of biomaterial-based tissue engineering strategies for peripheral nerve regeneration

Jiang

Tang²,

Li³

et al. 2022

Front. Bioeng. Biotechnol.

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Peripheral nerve injury is a clinically common injury that causes sensory dysfunction and locomotor system degeneration, which seriously affects the quality of the patients’ daily life. Long gapped defects in large nerve are difficult to repair via surgery and limited donor source of autologous nerve greatly challenges the successful nerve repair by transplantation. Significantly, remarkable progress has been made in repairing the peripheral nerve injury using artificial nerve grafts and a variety of products for peripheral nerve repair have emerged been approved globally in recent years. The raw materials of these commercial products includes natural/synthetic polymers, extracellular matrix. Despite a lot of effort, the desirable functional recovery still remains great challenges in long gapped nerve defects. Thus this review discusses the recent development of tissue engineering products for peripheral nerve repair and the design of bionic grafts improving the local microenvironment for accelerating nerve regeneration against locomotor disorder, which may provide potential strategies for the repair of long gaps or thick nerve defects by multifunctional biomaterials.

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Multifunctional chitin-based hollow nerve conduit for peripheral nerve regeneration and neuroma inhibition

Cited by 17 publications

References 53 publications

A critical review on polydopamine surface-modified scaffolds in musculoskeletal regeneration

A critical review on polydopamine surface-modified scaffolds in musculoskeletal regeneration

New techniques and methods for prevention and treatment of symptomatic traumatic neuroma: A systematic review

The success of biomaterial-based tissue engineering strategies for peripheral nerve regeneration

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