Multifunctional chitosan ferrogels for targeted cancer therapy by on-demand magnetically triggered drug delivery and hyperthermia

Sumitha, N.S.; Krishna, Nidhi G.; Sailaja, G. S.

doi:10.1016/j.bioadv.2022.213137

Cited by 10 publications

(8 citation statements)

References 60 publications

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“…The hydrogen bonds at the CS–ONC interface shift the carbonyl and hydroxyl stretching vibration, generating a broad band in CS4, between 1500 and 1700 cm –1 . A strong signal at 583 cm –1 in IONP denotes characteristic Fe–O stretching vibration . The IONP–polymer interactions move this peak to a lower wavenumber in the magnetic patches.…”

Section: Resultsmentioning

confidence: 99%

“…40 A strong signal at 583 cm −1 in IONP denotes characteristic Fe−O stretching vibration. 16 The IONP− polymer interactions move this peak to a lower wavenumber in the magnetic patches. Thus, the hydroxyl, amino, and carboxyl functional groups of the CS and ONC are employed to form a strong bioconjugate between the two and also to hold IONPs, forming a structurally stable magnetic polymer network (Figure 2c).…”

Section: Synthesis and Characterization Of Cs-onc Films And Magneticmentioning

confidence: 98%

“…Another method is to create nanocomposites by incorporating metal nanoparticles, metal oxides, graphite, etc . The polymer matrix acquires magnetic properties through the addition of magnetic nanoparticles that can be explored for magnetic hyperthermia and targeting . Superparamagnetic iron oxide nanoparticles (SPIONs) are of utmost interest as magnetic hyperthermia agents in view of their stability, biocompatibility, and ability to be functionalized with biopolymers.…”

Section: Introductionmentioning

confidence: 99%

“…12 The polymer matrix acquires magnetic properties through the addition of magnetic nanoparticles that can be explored for magnetic hyperthermia and targeting. 16 Superparamagnetic iron oxide nanoparticles (SPIONs) are of utmost interest as magnetic hyperthermia agents in view of their stability, biocompatibility, and ability to be functionalized with biopolymers. Associating tumor-specific medicines with these magnetic devices allows for simultaneous site-specific targeting, magnetic field-induced release kinetics, and magnetic hyperthermia.…”

Section: Introductionmentioning

confidence: 99%

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Chitosan-TEMPO-Oxidized Nanocellulose Magnetic Responsive Patches with Hyperthermia Potential for Smart Melanoma Therapy

Sumitha,

Krishna,

Sailaja

2023

ACS Appl. Polym. Mater.

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Melanoma treatment is hampered by high metastasis, limited skin penetration of drugs, and insufficient durability of the existing polymer-based drug delivery systems. This study proposes doxorubicin (DOX)-loaded magnetic patches comprising chitosan and TEMPO-oxidized nanocellulose as a potential magnetic drug delivery system. Magnetic patches were prepared by integrating superparamagnetic iron oxide nanoparticles (IONPs) into chitosan-TEMPO-oxidized nanocellulose films and then loaded with DOX. The magnetic, morphological, mechanical, and degradation properties were modulated by varying chitosan-to-IONP ratio and subsequently evaluated for magnetically triggered drug release, hyperthermia, and in vitro biofunctionality. The microtexture of the film surface indicates homogeneous IONP distribution (SEM-EDX) which contributes directly to the high mechanical strength (35–54 MPa) and magnetic sensitivity. These patches are biodegradable and cytocompatible (MTT assay, cell adhesion, and confocal imaging) with a 30–37% greater swelling index at tumor pH (relative to physiological pH) and exhibit superparamagnetism with a saturation magnetization value as high as 23.3 emu/g. The magnetic field-triggered delivery under a static magnetic field of 50 mT produced a release of >12% out of the total loaded amount within 1 h, while >24 h was required to attain the same release level in the absence of magnetic field. As per hyperthermia studies, the drug-loaded magnetic patch elevates the temperature to the therapeutic range (>42 °C) in less than 7 min. The efficacy of DOX-loaded magnetic patches in treating melanoma was evaluated using B16F10 cells, which exhibited a 79.55% reduction in cell viability after 5 days. A facile preparation method, magnetic hyperthermia, controlled chemotherapeutic effect, and limited complexities make them suitable for skin cancer therapeutics.

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Section: Resultsmentioning

confidence: 99%

Section: Synthesis and Characterization Of Cs-onc Films And Magneticmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Chitosan-TEMPO-Oxidized Nanocellulose Magnetic Responsive Patches with Hyperthermia Potential for Smart Melanoma Therapy

Sumitha,

Krishna,

Sailaja

2023

ACS Appl. Polym. Mater.

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“…Magnetic materials are widely used for the development of new technologies. In the environmental area, for example, these materials have been exploited to remove heavy metals and organic matter from water [36]; in the area of biotechnology, iron oxides have been used as heat delivery agents in magnetic hyperthermia systems, and also for the vectorization of drugs in drug delivery systems [26,34,[37][38][39][40].…”

Section: Properties Of Magnetic Materialsmentioning

confidence: 99%

Magnetic Gels in Skin Cancer Treatment: A Review of Potential Applications in Diagnostics, Drug Delivery and Hyperthermia

Bruschi

Nunes

2023

Pharmaceutics

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Skin cancer (SC) is affecting an increasing number of people worldwide. Its lesions affect mainly the most exposed regions of the skin. SC is classified into to main categories: non-melanoma (basal cell carcinoma of the epidermis and squamous cell carcinoma) and melanoma (the abnormal proliferation of melanocytes, which is rarer, more hazardous, and more deadly). Prevention and early diagnosis are important actions, and surgery is often considered. After the removal of cancerous lesions, the local administration of medicine can guarantee anticancer therapeutic action, rapid healing and the recovery of tissue, ensuring the absence of recurrence. Magnetic gels (MGs) have attracted increased attention regarding their pharmaceutical and biomedical applications. They are magnetic nanoparticles (e.g., iron oxide nanoparticles) dispersed in a polymeric matrix, which constitute adaptive systems under a magnetic field. MGs can combine magnetic susceptibility, high elasticity, and softness, and are thus useful platforms for diagnostics, drug delivery, and also for hyperthermia. This manuscript reviews MGs as a technological strategy for the treatment of SC. An overview of SC and the treatment, types, and methods of preparing MGs are discussed. Moreover, the applications of MGs in SC and their future perspectives are considered. The combination of polymeric gels and magnetic nanoparticles continues to be investigated, and new products must hit the market. Clinical trials and new products are expected, due to the important advantages of MGs.

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Cellulose nanofiber-created air barrier enabling closed-cell foams prepared via oven-drying

Wang,

Tian,

Chang

et al. 2025

Carbohydrate Polymers

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Multifunctional chitosan ferrogels for targeted cancer therapy by on-demand magnetically triggered drug delivery and hyperthermia

Cited by 10 publications

References 60 publications

Chitosan-TEMPO-Oxidized Nanocellulose Magnetic Responsive Patches with Hyperthermia Potential for Smart Melanoma Therapy

Chitosan-TEMPO-Oxidized Nanocellulose Magnetic Responsive Patches with Hyperthermia Potential for Smart Melanoma Therapy

Magnetic Gels in Skin Cancer Treatment: A Review of Potential Applications in Diagnostics, Drug Delivery and Hyperthermia

Cellulose nanofiber-created air barrier enabling closed-cell foams prepared via oven-drying

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