“…Furthermore, the precise control of gene knockdown provided by siRNA has allowed researchers to delineate important relationships between EWS/FLI and downstream targets such as MYC, IGFBP3, NR0B1, STEAP1, CALCB, and several neural crest specific genes [72] , [75] , [76] , [77] , [78] , [79] . The creation of nanoparticles containing these targeted oligonucleotides remains an ongoing area of investigation [80] , [81] . In addition, one such construct is currently being evaluated in the clinic (NCT02736565).…”