Multifunctional Drug Nanosystems: A Summary of Recent Researches at IMS/VAST

Nguyen, Xuan Phuc; TMai, T. T.; Ha, Phuong Thu; Pham, H.T.M.; Luu, Helen; M., H.; Tran, Dai Lam; Nguyen, Hoang‐Linh; Nguyen, Luong T. H.; Ho, Alexander; Hoang, Thi My Nhung

doi:10.1007/978-3-319-11776-8_14

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…Clinical studies have demonstrated that magnetic nanoparticle (MNP)-based hyperthermia enhances the cytotoxicity of some chemotherapeutic drugs [ 47 , 48 ], such as salinomycin [ 7 ], curcumin [ 9 ], DOX [ 12 ], and 17AAG [ 49 ]. Mild hyperthermia treatment (43–45 °C) can improve the sensitivity to drugs in the entire tumor by increasing cell spacing and permeability [ 50 , 51 , 52 , 53 ].…”

Section: Resultsmentioning

confidence: 99%

A Smart Hyperthermia Nanofiber-Platform-Enabled Sustained Release of Doxorubicin and 17AAG for Synergistic Cancer Therapy

Chen

Fujisawa

Takanohashi

et al. 2021

IJMS

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This study demonstrates the rational fabrication of a magnetic composite nanofiber mesh that can achieve mutual synergy of hyperthermia, chemotherapy, and thermo-molecularly targeted therapy for highly potent therapeutic effects. The nanofiber is composed of biodegradable poly(ε-caprolactone) with doxorubicin, magnetic nanoparticles, and 17-allylamino-17-demethoxygeldanamycin. The nanofiber exhibits distinct hyperthermia, owing to the presence of magnetic nanoparticles upon exposure of the mesh to an alternating magnetic field, which causes heat-induced cell killing as well as enhanced chemotherapeutic efficiency of doxorubicin. The effectiveness of hyperthermia is further enhanced through the inhibition of heat shock protein activity after hyperthermia by releasing the inhibitor 17-allylamino-17-demethoxygeldanamycin. These findings represent a smart nanofiber system for potent cancer therapy and may provide a new approach for the development of localized medication delivery.

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Section: Resultsmentioning

confidence: 99%

A Smart Hyperthermia Nanofiber-Platform-Enabled Sustained Release of Doxorubicin and 17AAG for Synergistic Cancer Therapy

Chen

Fujisawa

Takanohashi

et al. 2021

IJMS

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“…However, the development of polymeric NPs is not exclusive to biopolymeric systems, since they can also be obtained with biocompatible synthetic materials, which are mainly homopolymers and copolymers of polylactide (PLA) [34,35], polycaprolactone (PCL) [36], polyglycolic acid (PGA) [37,38] and acrylate-based polymers [39][40][41][42][43]. Likewise, the polymeric NPs are subclassified according to their architecture, where the most usual correspond to nanospheres [44][45][46][47][48], nanocapsules [8,[49][50][51][52], polymer nanoconjugates [53][54][55][56][57], and polyelectrolyte complexes (PECNs) [58][59][60][61][62]. Regarding PECNs, these can be obtained by several methodologies, being the traditional process of polyelectrolytic complexation (bottom-up method) one of the most used [63][64][65][66][67].…”

Section: Introductionmentioning

confidence: 99%

Development of Polyelectrolyte Complex Nanoparticles-PECNs Loaded with Ampicillin by Means of Polyelectrolyte Complexation and Ultra-High Pressure Homogenization (UHPH)

et al. 2020

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This study was focused on synthesizing, characterizing and evaluating the biological potential of Polyelectrolyte Complex Nanoparticles (PECNs) loaded with the antibiotic ampicillin. For this, the PECNs were produced initially by polyelectrolytic complexation (bottom-up method) and subsequently subjected to ultra-high pressure homogenization-UHPH (top-down method). The synthetic polymeric materials corresponding to the sodium salt of poly(maleic acid-alt-octadecene) (PAM-18Na) and the chloride salt of Eudragit E-100 (EuCl) were used, where the order of polyelectrolyte complexation, the polyelectrolyte ratio and the UHPH conditions on the PECNs features were evaluated. Likewise, PECNs were physicochemically characterized through particle size, polydispersity index, zeta potential, pH and encapsulation efficiency, whereas the antimicrobial effect was evaluated by means of the broth microdilution method employing ampicillin sensitive and resistant S. aureus strains. The results showed that the classical method of polyelectrolyte complexation (bottom-up) led to obtain polymeric complexes with large particle size and high polydispersity, where the 1:1 ratio between the titrant and receptor polyelectrolyte was the most critical condition. In contrast, the UHPH technique (top-down method) proved high performance to produce uniform polymeric complexes on the nanometric scale (particle size < 200 nm and PDI < 0.3). Finally, it was found there was a moderate increase in antimicrobial activity when ampicillin was loaded into the PECNs.

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Multifunctional Drug Nanosystems: A Summary of Recent Researches at IMS/VAST

Cited by 2 publications

References 15 publications

A Smart Hyperthermia Nanofiber-Platform-Enabled Sustained Release of Doxorubicin and 17AAG for Synergistic Cancer Therapy

A Smart Hyperthermia Nanofiber-Platform-Enabled Sustained Release of Doxorubicin and 17AAG for Synergistic Cancer Therapy

Development of Polyelectrolyte Complex Nanoparticles-PECNs Loaded with Ampicillin by Means of Polyelectrolyte Complexation and Ultra-High Pressure Homogenization (UHPH)

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