Multifunctional Fe₃O₄–CdTe@SiO₂–carboxymethyl chitosan drug nanocarriers: synergistic effect towards magnetic targeted drug delivery and cell imaging

Abstract

In this study, novel multifunctional core shell structure Fe 3 O 4 -CdTe@SiO 2 -carboxymethyl chitosan drug nanocarriers (MDNs) were developed from carboxymethyl chitosan (CMCS) and magnetic fluorescent composite nanoparticles (Fe 3 O 4 -CdTe@SiO 2 ). After processing parameters affecting the end product properties were systematically optimized, Doxorubicin (DOX), a weak base type in clinic anti-cancer drug, was successfully incorporated into the polymeric complex. The formed the MDNs show a uniform size around 160 nm, good loaded content (7.06%) and encapsulation efficiency (76.8%), water-dispersion and colloidal stability in a physiological environment, magnetic movability and red emission at room temperature. In the study of the DOX cumulative release from the MDNs, it could reach 64% at pH 5.3 and 33% at pH 7.4 within 24 h, showing pH-regulated drug release. In in vitro experiments, blank MDNs exhibited excellent biocompatibility even at the high concentration of 1 mg mL À1 , and favourable fluorescent labelling properties overcoming cellular barriers to enter the intracellular region and light up the cells. For cancer cell treatment (human prostate cancer cell line PC3M), when 200 mg mL À1 of DOX loaded MDNs was used, they showed obvious anti-cancer activity and a satisfactory therapeutic effect. These characteristics made the as-synthesized MDNs an attractive candidate for the encapsulation and controlled release of an anti-cancer drug for magnetic targeted delivery, fluorescence imaging and cancer treatment.

Chitosan‐based multifunctional nanomedicines and theranostics for targeted therapy of cancer

“…In another study, Wang et al. investigated an innovative multifunctional core‐shell structure, Fe 3 O 4 –CdTe@SiO 2 –carboxymethyl CS drug nanocarrier (MDN), which was synthesized from CMCS and magnetic fluorescent composite NPs (Fe 3 O 4 –CdTe@SiO 2 ) . After processing, parameters affecting the product properties were systematically optimized and DOX was successfully combined with the polymeric complex.…”

Anticancer drug delivery systems based on inorganic nanocarriers with fluorescent tracers

“…Wang et al developed multifunctional, core‐shell‐structured Fe 3 O 4 ‐CdTe@SiO 2 ‐carboxymethyl chitosan composite nanoparticles (MDNs) for magnetically targeted drug delivery, and cellular imaging . The MDNs possessed the following properties including excellent biocompatibility, desirable solubility at physiological condition and long‐term blood circulation, the Fe 3 O 4 –CdTe@SiO 2 nanoparticles have a uniform size about 50 nm, the drug loaded content was 7.06 × 10 3 mg g −1 and encapsulation efficiency was 76.8%.…”

SPIO@SiO2–Re@PEG nanoparticles as magneto-optical dual probes and sensitizers for photodynamic therapy

“…Re(CO) 5 OTf 45 (OTf ¼ CF 3 SO 3 , 37.2 mg, 7.83 Â 10 À2 mmol) was dissolved in dry toluene (8 mL) under nitrogen, and added with 15.5 mg of 1,10-phenanthroline monohydrate (7.8 Â 10 À2 mmol). The mixture was heated at 100 C for 5 h. Finally, the temperature was lowered to 0 C, giving an orange powder, from which the intermediate product [Re(phen)(CO) 3 (OTf)] was isolated by washing with toluene (3 mL, 2 times) and drying under vacuum.…”