Multifunctional Ginger Nanofiber Hydrogels with Tunable Absorption: The Potential for Advanced Wound Dressing Applications

Abstract

In this study, ginger residue from juice production was evaluated as a raw material resource for preparation of nanofiber hydrogels with multifunctional properties for advanced wound dressing applications. Alkali treatment was applied to adjust the chemical composition of ginger fibers followed by TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl radical)-mediated oxidation prior to nanofiber isolation. The effect of alkali treatment on hydrogel properties assembled through vacuum filtration without addition of any chemical cross-linker was evaluated. An outstanding absorption ability of 6200% combined with excellent mechanical properties, tensile strength of 2.1 ± 0.2 MPa, elastic modulus of 15.3 ± 0.3 MPa, and elongation at break of 25.1%, was achieved without alkali treatment. Furthermore, the absorption capacity was tunable by applying alkali treatment at different concentrations and by adjusting the hydrogel grammage. Cytocompatibility evaluation of the hydrogels showed no significant effect on human fibroblast proliferation in vitro. Ginger essential oil was used to functionalize the hydrogels by providing antimicrobial activity, furthering their potential as a multifunctional wound dressing.

Synthesis and in vitro evaluation of natural drug loaded polymeric films for cardiovascular applications

“…After conducting extensive cytocompatibility assays, declared the formulated ginger loaded nanofibers as biocompatible and can be used for biomedical applications such as wound dressings. 53…”

“…After conducting extensive cytocompatibility assays, declared the formulated ginger loaded nanofibers as biocompatible and can be used for biomedical applications such as wound dressings. 53 Clot lysis activity. The results of clot lysis activity of natural compound drug loaded polymeric films is depicted in Figures 11-13.…”

A Review on Cellulose-based Materials for Biomedicine

“…It offered strong adhesion to the wound and promoted epithelialization after 4 days without observation of allergic or inflammation during the treatment [41]. A cellulose hydrogel was prepared from the alkali treatment and TEMPO-mediated oxidation of ginger fibers (T-GNF) [208]. It was designed via a simple vacuum-assisted filtration using only ginger nanofibers without cross-linking treatments.…”

“…The preparation method required low energy and few components for the production procedure. The antibacterial and wound healing of the material were investigated [208]. The material exhibited a closure rate for wound healing without significant antibacterial activity against E. coli and S. aureus [208].…”

“…The antibacterial and wound healing of the material were investigated [208]. The material exhibited a closure rate for wound healing without significant antibacterial activity against E. coli and S. aureus [208]. 3D printing of NC hydrogel scaffolds was reported for wound healing [209].…”