Multifunctional Gold Nanoparticles for Improved Diagnostic and Therapeutic Applications: A Review

Sibuyi, Nicole Remaliah Samantha; Moabelo, Koena Leah; Fadaka, Adewale Oluwaseun; Meyer, Mervin; Onani, Martin O.; Madiehe, Abram Madimabe

doi:10.1186/s11671-021-03632-w

Cited by 119 publications

(71 citation statements)

References 167 publications

(567 reference statements)

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“…Of course, if the nanoparticle reaches various organs and tissues, it can escape the phagocytosis of tissue macrophages. It will further reach the location of tissue disease [ 59 ]. Topical applications of nanoparticles, such as ophthalmic formulations, can directly achieve the therapeutic goals discussed in this paper due to their direct contact with the target site.…”

Section: Discussionmentioning

confidence: 99%

“…administration, significantly higher than the half-life of iodine-based drugs (5–10 min). The use of AuNPs as contrast agents has shown potential in imaging systems [ 59 ].…”

Section: Cardiac and Vascular Injurymentioning

confidence: 99%

“…The exact antibacterial mechanism of AuNPs has not been fully elucidated. However, possible mechanisms include inducing microbial death through membrane damage, generating ROS and oxidative stress, causing cellular organ dysfunction, and changes in gene expression and cell signaling [ 59 , 64 ]. Gold nanoparticles were used in external preparations and did not agglomerate after being added to a cream mixture.…”

Section: Antimicrobialsmentioning

confidence: 99%

“…Recently, the most important applications of nanogold have been in the development of coronavirus vaccines and the detection of viruses. These studies stress the indispensable role that nanogold particles play in biomedicine [ 59 ].…”

Section: Metabolic Syndrome and Othersmentioning

confidence: 99%

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Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Wang

Hsiao

et al. 2022

Molecules

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Gold has always been regarded as a symbol of nobility, and its shiny golden appearance has always attracted the attention of many people. Gold has good ductility, molecular recognition properties, and good biocompatibility. At present, gold is being used in many fields. When gold particles are as small as several nanometers, their physical and chemical properties vary with their size in nanometers. The surface area of a nano-sized gold surface has a special effect. Therefore, gold nanoparticles can, directly and indirectly, give rise to different biological activities. For example, if the surface of the gold is sulfided. Various substances have a strong chemical reactivity and are easy to combine with sulfhydryl groups; hence, nanogold is often used in biomedical testing, disease diagnosis, and gene detection. Nanogold is easy to bind to proteins, such as antibodies, enzymes, or cytokines. In fact, scientists use nanogold to bind special antibodies, as a tool for targeting cancer cells. Gold nanoparticles are also directly cytotoxic to cancer cells. For diseases caused by inflammation and oxidative damage, gold nanoparticles also have antioxidant and anti-inflammatory effects. Based on these unique properties, gold nanoparticles have become the most widely studied metal nanomaterials. Many recent studies have further demonstrated that gold nanoparticles are beneficial for humans, due to their functional pharmacological properties in a variety of diseases. The content of this review will be the application of gold nanoparticles in treating or diagnosing pressing diseases, such as cancers, retinopathy, neurological diseases, skin disorders, bowel diseases, bone cartilage disorders, cardiovascular diseases, infections, and metabolic syndrome. Gold nanoparticles have shown very obvious therapeutic and application potential.

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Section: Discussionmentioning

confidence: 99%

“…administration, significantly higher than the half-life of iodine-based drugs (5–10 min). The use of AuNPs as contrast agents has shown potential in imaging systems [ 59 ].…”

Section: Cardiac and Vascular Injurymentioning

confidence: 99%

Section: Antimicrobialsmentioning

confidence: 99%

Section: Metabolic Syndrome and Othersmentioning

confidence: 99%

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Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Wang

Hsiao

et al. 2022

Molecules

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“…These applications include the use of AuNPs in diagnostic tracers, biosensing, photothermal and radiotherapy, and cell imaging [ 8 , 9 , 10 ]. In addition, the approval of using AuNPs by the Food and Drug Administration (FDA) increased the applications of AuNPs as therapeutic agents in nanomedicine, such as cancer therapy and drug carriers [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Green Synthesized Gold Nanoparticles Using Extract of Leptadenia hastata against Invasive Pulmonary Aspergillosis

Abdallah

Ali

2022

JoF

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Gold nanoparticles are widely used in the biomedical field for the treatment of several diseases, including cancer, inflammatory diseases, and immune system disorders, due to their distinctive physicochemical characteristics. In this study, we investigated the therapeutic potential of green synthesized gold nanoparticles using ethanolic leaf extract of Leptadenia hastata (LH-AuNPs) against invasive pulmonary aspergillosis (IPA) in mice. UV/visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX), and zeta potential were used to characterize the biofabricated LH-AuNPs. Antifungal activity of LH-AuNPs was determined by MTT assay, (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide), time-kill assay, and radial growth inhibition. TEM and SEM were used to examine the mode of the antifungal action of LH-AuNPs. The in vivo activity of LH-AuNPs against IPA was studied using a well-established IPA mouse model. LH-AuNPs excreted antifungal activity against Aspergillus fumigatus with MIC 64 µg/mL and inhibited the radial growth of A. fumigatus by 30% compared to the control. LH-AuNPs caused distortion and collapse of fungal hyphae and deterioration of cell walls. Interestingly, LH-AuNPs did not display any cytotoxicity on cultured primary bone marrow stem cells (BMSCs) or A549 human lung cell line in vitro at MIC concentration. IPA mice treated with LH-AuNPs displayed significant lung tissue repair without any in vivo cytotoxicity. LH-AuNPs administration showed significant suppression of fungal burden and gliotoxin production in the lung. In addition, LH-AuNPs inhibited IPA-induced pro-inflammatory cytokines production, including interleukin-1 (IL-1), interleukin-17 (IL-17), and tumor necrosis factor-alpha (TNF-α), and reduced oxidative stress in lung. In conclusion, our data provide LH-AuNPs as a novel nanoparticle therapy for IPA.

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Advanced Nanomaterials for Cancer Therapy: Gold, Silver, and Iron Oxide Nanoparticles in Oncological Applications

Singh,

Pandit,

Balusamy

et al. 2024

Adv Healthcare Materials

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Cancer remains one of the most challenging health issues globally, demanding innovative therapeutic approaches for effective treatment. Nanoparticles, particularly those composed of gold, silver, and iron oxide, have emerged as promising candidates for changing cancer therapy. This comprehensive review demonstrates the landscape of nanoparticle‐based oncological interventions, focusing on the remarkable advancements and therapeutic potentials of gold, silver, and iron oxide nanoparticles. Gold nanoparticles have garnered significant attention for their exceptional biocompatibility, tunable surface chemistry, and distinctive optical properties, rendering them ideal candidates for various cancer diagnostic and therapeutic strategies. Silver nanoparticles, renowned for their antimicrobial properties, exhibit remarkable potential in cancer therapy through multiple mechanisms, including apoptosis induction, angiogenesis inhibition, and drug delivery enhancement. With their magnetic properties and biocompatibility, iron oxide nanoparticles offer unique cancer diagnosis and targeted therapy opportunities. This review critically examines the recent advancements in the synthesis, functionalization, and biomedical applications of these nanoparticles in cancer therapy. Moreover, the challenges are discussed, including toxicity concerns, immunogenicity, and translational barriers, and ongoing efforts to overcome these hurdles are highlighted. Finally, insights into the future directions of nanoparticle‐based cancer therapy and regulatory considerations, are provided aiming to accelerate the translation of these promising technologies from bench to bedside.

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Multifunctional Gold Nanoparticles for Improved Diagnostic and Therapeutic Applications: A Review

Cited by 119 publications

References 167 publications

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Therapeutic Potential of Green Synthesized Gold Nanoparticles Using Extract of Leptadenia hastata against Invasive Pulmonary Aspergillosis

Advanced Nanomaterials for Cancer Therapy: Gold, Silver, and Iron Oxide Nanoparticles in Oncological Applications

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