Multifunctional graphene oxide nanoparticles for drug delivery in cancer

Itoo, Asif Mohd; Vemula, Sree Lakshmi; Gupta, Mahima Tejasvni; Giram, Mahesh Vilasrao; Kumar, Sangishetty Akhil; Ghosh, Balaram; Biswas, Swati

doi:10.1016/j.jconrel.2022.08.011

Cited by 111 publications

(51 citation statements)

References 310 publications

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“…Recent interest on graphene nanomaterials, particularly reduced graphene oxide, is largely attributed to its remarkable physicochemical features. Such features include a large surface area, high charge capacity, outstanding thermal conductivity, mechanical properties, and electron transfer capacities [ 19 , 20 , 21 ]. Modifications of graphene with appropriate functional groups confer new characteristics onto this material, which vastly expand its application in fields including biosensing, drug delivery, and biomedical science [ 29 , 31 ].…”

Section: Resultsmentioning

confidence: 99%

“…Graphene-based nanomaterials are envisaged as a class of magic materials because of their unique structure and excellent mechanical, optical, and electrical properties [ 16 , 17 , 18 ]. For instance, their large surface area, covalent, and noncovalent binding capacities of biomolecules, polymers, and organic drug molecules make graphene-based nanomaterials ideal matrices for adsorption and conjugation in the fields of biosensor [ 19 ], drug delivery [ 20 ], and biomedicine [ 21 ]. For example, Asif et al reported a Zn-NiAl layered double hydroxide/rGO superlattice-based electrochemical sensor for the simultaneous detection of dopamine, uric acid, and ascorbic acid owing to the outstanding electrocatalytic activity of the superlattice, partially because of the superb electrical conductivity of rGO [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

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A Hemin–Graphene Nanocomposite-Based Aptasensor for Ultrasensitive Colorimetric Quantification of Leukaemia Cells Using Magnetic Enrichment

Zhang

Lai

et al. 2022

Biosensors

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Diagnostic blood cell counting is of limited use in monitoring a minimal number of leukaemia cells, warranting further research to develop more sensitive and reliable techniques to identify leukaemia cells in circulation. In this work, a hemin–graphene nanocomposite-based aptasensor was developed for ultrasensitive colorimetric detection of leukaemia cells (CEM) using magnetic enrichment. Hemin-conjugated graphene oxide nanocomposites (HGNs) were prepared by hydrazine reduction using graphene oxide nanosheets and hemins. Hence, the prepared HGNs become able to absorb single-stranded DNA and acquire peroxidase-like activity. The aptamer sgc8c, which recognizes a specific target on leukaemia cells, was absorbed onto HGNs to capture the target CEM cancer cells. The captured target cells that associated with the HGNs were then concentrated and separated by magnetic beads (MBs) coated with sgc8c aptamers, forming a HGN–cell–MB sandwich structure. These sandwich structures can be quantified via an oxidation reaction catalysed by HGNs. By utilizing dual signal amplification effects generated by magnetic enrichment and the improved peroxidase activity of HGNs, the biosensor allowed for highly sensitive detection of 10 to 105 CEM cells with an ultra-low limit of detection (LOD) of 10 cells under optimal conditions. It is expected that the proposed aptasensor can be further employed in monitoring the minimal residual disease during the treatment of leukaemia.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Hemin–Graphene Nanocomposite-Based Aptasensor for Ultrasensitive Colorimetric Quantification of Leukaemia Cells Using Magnetic Enrichment

Zhang

Lai

et al. 2022

Biosensors

View full text Add to dashboard Cite

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“…A variety of biomaterials based on graphene and its derivatives, including graphene nanogrids [ 149 ], graphene-oxide-based hydrogels [ 150 ], and graphene oxide foams [ 146 ], have great application prospects in ontogenesis, tissue regeneration, cancer therapy, and drug delivery [ 151 , 152 , 153 ], exhibiting excellent biological properties, electrochemical properties, high surface area, excellent mechanical strength, strong hydrophilicity, and high adsorption capacity [ 151 , 154 , 155 ], along with effects on stem cell differentiation and proliferation [ 156 , 157 ]. Among them, graphene oxide (GO) and its reduced form, reduced graphene oxide (rGO), are the most widely studied graphene-derived forms to date [ 151 ].…”

Section: Different Types Of Stimuli-responsive Hydrogelmentioning

confidence: 99%

Applications of Stimuli-Responsive Hydrogels in Bone and Cartilage Regeneration

Xing

Deng

et al. 2023

Pharmaceutics

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Bone and cartilage regeneration is an area of tremendous interest and need in health care. Tissue engineering is a potential strategy for repairing and regenerating bone and cartilage defects. Hydrogels are among the most attractive biomaterials in bone and cartilage tissue engineering, mainly due to their moderate biocompatibility, hydrophilicity, and 3D network structure. Stimuli-responsive hydrogels have been a hot topic in recent decades. They can respond to external or internal stimulation and are used in the controlled delivery of drugs and tissue engineering. This review summarizes current progress in the use of stimuli-responsive hydrogels in bone and cartilage regeneration. The challenges, disadvantages, and future applications of stimuli-responsive hydrogels are briefly described.

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“…Cancer is one of the most worrisome illnesses, particularly in affluent nations. Nearly 8 million people die from cancer each year, contributing significantly to the burden of cancer-related mortality and morbidity worldwide. − Chemotherapy, surgery, radiotherapy, and, more recently, small molecule-based treatments and immunotherapy, as well as a combination of these approaches, are the current clinical approaches for cancer therapy. Surgery is typically the first course of treatment; however, if metastasis has already taken place, it may not be the most appropriate treatment option.…”

Section: Introductionmentioning

confidence: 99%

Nanotherapeutic Intervention in Photodynamic Therapy for Cancer

et al. 2022

Self Cite

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The clinical need for photodynamic therapy (PDT) has been growing for several decades. Notably, PDT is often used in oncology to treat a variety of tumors since it is a low-risk therapy with excellent selectivity, does not conflict with other therapies, and may be repeated as necessary. The mechanism of action of PDT is the photoactivation of a particular photosensitizer (PS) in a tumor microenvironment in the presence of oxygen. During PDT, cancer cells produce singlet oxygen (1O2) and reactive oxygen species (ROS) upon activation of PSs by irradiation, which efficiently kills the tumor. However, PDT’s effectiveness in curing a deep-seated malignancy is constrained by three key reasons: a tumor’s inadequate PS accumulation in tumor tissues, a hypoxic core with low oxygen content in solid tumors, and limited depth of light penetration. PDTs are therefore restricted to the management of thin and superficial cancers. With the development of nanotechnology, PDT’s ability to penetrate deep tumor tissues and exert desired therapeutic effects has become a reality. However, further advancement in this field of research is necessary to address the challenges with PDT and ameliorate the therapeutic outcome. This review presents an overview of PSs, the mechanism of loading of PSs, nanomedicine-based solutions for enhancing PDT, and their biological applications including chemodynamic therapy, chemo-photodynamic therapy, PDT–electroporation, photodynamic–photothermal (PDT–PTT) therapy, and PDT–immunotherapy. Furthermore, the review discusses the mechanism of ROS generation in PDT advantages and challenges of PSs in PDT.

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Multifunctional graphene oxide nanoparticles for drug delivery in cancer

Cited by 111 publications

References 310 publications

A Hemin–Graphene Nanocomposite-Based Aptasensor for Ultrasensitive Colorimetric Quantification of Leukaemia Cells Using Magnetic Enrichment

A Hemin–Graphene Nanocomposite-Based Aptasensor for Ultrasensitive Colorimetric Quantification of Leukaemia Cells Using Magnetic Enrichment

Applications of Stimuli-Responsive Hydrogels in Bone and Cartilage Regeneration

Nanotherapeutic Intervention in Photodynamic Therapy for Cancer

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