Multifunctional hydrogel with reactive oxygen species scavenging and photothermal antibacterial activity accelerates infected diabetic wound healing

He, Yuanmeng; Liu, Kaiyue; Guo, Shen; Chang, Rong Seng; Zhang, Chen; Guan, Fangxia; Yao, M.

doi:10.1016/j.actbio.2022.11.023

Cited by 78 publications

(40 citation statements)

References 67 publications

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“…In particular, chemical functionalization with 2,3,4-trihydroxybenzaldehyde and simultaneous ionic crosslinking by iron (III) ions were carried out on a tridimensional network with both antioxidant and antibacterial properties [ 129 ]. Similarly, a multifunctional hydrogel with significant scavenging properties and photothermal antibacterial capacity based on oxidized dextran, gallic acid-grafted gelatin, and Fe 3+ ions, was proposed for the treatment of infected wound in diabetic mice [ 130 ]. In this way a double-crosslinked network was synthesized by the dynamical Schiff-base bonds involving the aldehyde groups in the dextran and amino groups of the functionalized GL, while metal coordination bonds were formed between Fe 3+ ions and hydroxyl carboxyl groups of the protein.…”

Section: Polymeric Compoundsmentioning

confidence: 99%

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

et al. 2023

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Rapid and complete wound healing is a clinical emergency, mainly in pathological conditions such as Type 2 Diabetes mellitus. Many therapeutic tools are not resolutive, and the research for a more efficient remedial remains a challenge. Wound dressings play an essential role in diabetic wound healing. In particular, biocompatible hydrogels represent the most attractive wound dressings due to their ability to retain moisture as well as ability to act as a barrier against bacteria. In the last years, different functionalized hydrogels have been proposed as wound dressing materials, showing encouraging outcomes with great benefits in the healing of the diabetic wounds. Specifically, because of their excellent biocompatibility and biodegradability, natural bioactive compounds, as well as biomacromolecules such as polysaccharides and protein, are usually employed in the biomedical field. In this review, readers can find the main discoveries regarding the employment of naturally occurring compounds and biopolymers as wound healing promoters with antibacterial activity. The emerging approaches and engineered devices for effective wound care in diabetic patients are reported and deeply investigated.

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Section: Polymeric Compoundsmentioning

confidence: 99%

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

et al. 2023

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“…Correspondingly, the two peaks at 3281 and 3171 cm –1 in MH-2.5 that are assigned to the N–H stretching of primary amino groups combined to form one broad peak. In accordance with these changes, a new peak appeared at 1664 cm –1 in spectrum of cured MHG-C, and this signal is very likely related to the formation of a CN bond. , In addition, the Raman spectra (Figure b) showed more obvious evidence, especially a new and strong peak at 1592 cm –1 appearing in the spectrum of cured MHG-C. This signal was assigned to CN stretching by referring to the literature, further confirming that the Schiff base has been formed.…”

Section: Results and Discussionmentioning

confidence: 99%

Long-Chain Polyamine-Glyoxal Wood Adhesive: Formaldehyde-Free, Green Synthesis, and Ultra-Performances

Jiang,

Duan,

Liu

et al. 2023

ACS Sustainable Chem. Eng.

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Formaldehyde emission from wood-based products has been a threat to human health and the environment due to the use of formaldehyde-based adhesives. Glyoxal (G) was once regarded as a promising substitute for formaldehyde due to its formaldehyde-like reactivity and low toxicity. However, many studies have indicated that the urea-glyoxal (UG) and melamine-glyoxal (MG) reactions did not lead to the desired adhesion property due to cyclization reactions. To prevent cyclization, in this study, a long-chain melamine-1,6-hexanediamine (MH) polymer was used with glyoxal to fabricate wood adhesive via a facile and clean strategy. In contrast to previously reported glyoxal-related wood adhesives, the MHG adhesive exhibited a lower cure temperature, much higher bonding strength, and far superior water resistance. Particularly, when a low hot-press temperature of 80 °C was applied, a dry bonding strength above 2.42 MPa (100% wood failure) and a wet bonding strength (boiling in water for 3 h) of 1.62 MPa were achieved for plywood. With a higher cure temperature of 120 °C applied, a bonding strength above 1.50 MPa was retained with 100% wood failure even after boiling for 72 h. Structural characterizations suggested that the outstanding performances of the MHG adhesive can be attributed to easy formation of highly stable conjugated imine bonds (−N�C−C�N−).

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Section: Application Of Different Adhesive Materials In the Biomedica...mentioning

confidence: 99%

“…150,151 Polyphenol mixtures are more effective than pure compounds. 152,153 Therefore, current research has focused on the antibacterial properties of polyphenol mixtures rather than single compounds. 154,155 Wu et al reported the synthesis of cationic polyelectrolyte brushes grafted with bacterial cellulose (BC) nanofibers in polyacrylamide hydrogels.…”

Section: Antibacterial Applicationsmentioning

confidence: 99%

Recent advances in adhesive materials used in the biomedical field: adhesive properties, mechanism, and applications

Liu

2023

J. Mater. Chem. B

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Multifunctional hydrogel with reactive oxygen species scavenging and photothermal antibacterial activity accelerates infected diabetic wound healing

Cited by 78 publications

References 67 publications

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

Long-Chain Polyamine-Glyoxal Wood Adhesive: Formaldehyde-Free, Green Synthesis, and Ultra-Performances

Recent advances in adhesive materials used in the biomedical field: adhesive properties, mechanism, and applications

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