Multifunctional metal–organic framework heterostructures for enhanced cancer therapy

Liu, Jintong; Huang, Jing; Zhang, Lei; Lei, Jianping

doi:10.1039/d0cs00178c

Cited by 180 publications

(82 citation statements)

References 305 publications

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“…In addition to the nanomaterials mentioned above, some other nanomaterials such as metal-organic frameworks (MOFs) have also been explored as PTAs for PTT applications. MOFs are a class of molecular crystalline materials that consist of metal ions or clusters bridged by organic linkers [125]. Zhang et al prepared zirconium-ferriporphyrin MOF (Zr-FeP) nanoshuttles by a simple one-pot hydrothermal strategy and then loaded heat shock protein 70 (Hsp70) inhibitor siRNA on the nanoshuttles to obtain siRNA/Zr-FeP [126].…”

Section: Other Nanomaterialsmentioning

confidence: 99%

Nanomaterials and their composite scaffolds for photothermal therapy and tissue engineering applications

Sun

Chen

Sutrisno

et al. 2021

Science and Technology of Advanced Materials

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Photothermal therapy (PTT) has attracted broad attention as a promising method for cancer therapy with less severe side effects than conventional radiation therapy, chemotherapy and surgical resection. PTT relies on the photoconversion capacity of photothermal agents (PTAs), and a wide variety of nanomaterials have been employed as PTAs for cancer therapy due to their excellent photothermal properties. The PTAs are systematically or locally administered and become enriched in cancer cells to increase ablation efficiency. In recent years, PTAs and three-dimensional scaffolds have been hybridized to realize the local delivery of PTAs for the repeated ablation of cancer cells. Meanwhile, the composite scaffolds can stimulate the reconstruction and regeneration of the functional tissues and organs after ablation of cancer cells. A variety of composite scaffolds of photothermal nanomaterials have been prepared to combine the advantages of different modalities to maximize their therapeutic efficacy with minimal side effects. The synergistic effects make the composite scaffolds attractive for biomedical applications. This review summarizes these latest advances and discusses the future prospects.

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Section: Other Nanomaterialsmentioning

confidence: 99%

Nanomaterials and their composite scaffolds for photothermal therapy and tissue engineering applications

Sun

Chen

Sutrisno

et al. 2021

Science and Technology of Advanced Materials

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“…It is impossible to state which MOF is the best vaccine delivery system since the type of immune cell, cancer cell, maturation markers and cytokines under observation are different. Nevertheless, all OVA-containing nMOFs allowed DC or macrophage maturation, due to efficient antigen release via pH-[ 80 , 84 – 89 ] or redox-responsive [ 86 ] behavior. All cytokine levels recorded in vitro (DCs, macrophages) and ex-vivo (splenocytes), were higher for cells incubated with the nMOFs than for those simply incubated with free OVA.…”

Section: Immunotherapymentioning

confidence: 99%

Recent Advances in Nanoscale Metal–Organic Frameworks Towards Cancer Cell Cytotoxicity: An Overview

Harvey

Plé

2021

J Inorg Organomet Polym

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The fight against cancer has always been a prevalent research topic. Nanomaterials have the ability to directly penetrate cancer cells and potentially achieve minimally invasive, precise and efficient tumor annihilation. As such, nanoscale metal organic frameworks (nMOFs) are becoming increasingly attractive as potential therapeutic agents in the medical field due to their high structural variability, good biocompatibility, ease of surface functionalization as well as their porous morphologies with tunable cavity sizes. This overview addresses five different common strategies used to find cancer therapies, while summarizing the recent progress in using nMOFs as cytotoxic cancer cell agents largely through in vitro studies, although some in vivo investigations have also been reported. Chemo and targeted therapies rely on drug encapsulation and delivery inside the cell, whereas photothermal and photodynamic therapies depend on photosensitizers. Concurrently, immunotherapy actively induces the body to destroy the tumor by activating an immune response. By choosing the appropriate metal center, ligands and surface functionalization, nMOFs can be utilized in all five types of therapies. In the last section, the future prospects and challenges of nMOFs with respect to the various therapies will be presented and discussed. Graphic Abstract

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“…[ 5‐9 ] Thanks to these unique advantages, the application fields of MOFs cover gas storage/separation, [ 10‐13 ] catalysis, [ 14‐17 ] sensing, [ 18‐22 ] environmental remediation, [ 23‐27 ] proton conduction, [ 28‐31 ] energy storage, [ 32‐34 ] and even biomedical applications. [ 35‐38 ] Nevertheless, the large‐ scale commercialization of MOFs is seriously limited because of their intrinsic fragility, mechanical instability, and unworkability.…”

Section: Introductionmentioning

confidence: 99%

Recent Progress in Metal‐Organic Frameworks@Cellulose Hybrids and Their Applications

et al. 2021

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In recent years, metal‐organic frameworks (MOFs) are attracting increasing attention due to their charming properties. However, the intrinsic fragility, powdered crystalline state, and poor processibility of MOFs hinder their further application. By this, the designs of MOF‐based aerogels, hydrogels, membranes are effective ways to solve this problem. Graphene, silica, synthetic polymer and cellulose are the commonly used raw materials for fabricating MOF‐based aerogels, hydrogels, and membranes. Among them, cellulose and its derivatives are the best candidates to support the powdered MOFs from the perspectives of economy, environmental protection and property. This review focuses on discussing the advantages of MOF@cellulose hybrids in applications such as water treatment, antibacterial, gas separation and adsorption, energy storage, drug delivery, catalysis, and other smart composites. MOF@cellulose‐based aerogels, hydrogels and membranes can provide valuable guidance for investigating the practical application of MOFs in terms of processability, reusability, stability and easiness in handling.

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Multifunctional metal–organic framework heterostructures for enhanced cancer therapy

Abstract: We review the general principle of the design and functional modulation of nanoscaled MOF heterostructures, and biomedical applications in enhanced therapy.

Cited by 180 publications

References 305 publications

Nanomaterials and their composite scaffolds for photothermal therapy and tissue engineering applications

Nanomaterials and their composite scaffolds for photothermal therapy and tissue engineering applications

Recent Advances in Nanoscale Metal–Organic Frameworks Towards Cancer Cell Cytotoxicity: An Overview

Recent Progress in Metal‐Organic Frameworks@Cellulose Hybrids and Their Applications

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