Multifunctional Microelectrode for Low-Voltage Pulsed Field Ablation in Atrial Fibrillation

Xu, Mengfei; Hong, Wen; Song, Ziliang; Guo, Zhejun; Wang, Longchun; You, Minmin; Lin, Zude; Qin, Mu; Liu, Jingquan

doi:10.1109/led.2022.3208927

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…[31,32] More importantly, almost all studies rely on open surgical access, such as thoracotomy, which may lead to severe cardiac burden or surgical infection. [21,28,[33][34][35] Cardiac surgery via minimally invasive implantation is often associated with minimal trauma and short recovery time and is significantly more feasible in the clinic. [36] Therefore, medical electronics enabling low-voltage PFA with high precision through minimally invasive procedures are essential.…”

Section: Introductionmentioning

confidence: 99%

A High‐Precision, Low‐Voltage Pulsed Field Ablation Device with Capability of Minimally Invasive Surgery

Song

Hong

et al. 2023

Adv Funct Materials

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Pulsed field ablation is a novel approach to treating 33.5 million patients with atrial fibrillation and offers a tissue‐specific advantage over conventional radiofrequency ablation and cryoablation. However, for complex structural targets in the heart, current electrodes often damage non‐target areas due to inaccurate ablation and have to employ electrical pulses with amplitudes of several kilovolts. Herein, materials and designs of a catheter‐integrated microelectrode and sensors that can be used for high‐precision and low‐voltage pulsed field ablation through minimally invasive operation on a large animal model, is reported. The device with a new electrode configuration supports point‐by‐point ablation with a width of 3.8 mm (≈1/10 that of a typical ablation electrode) for individual lesions at the voltage of 300 V (an order of magnitude reduction compared to the current state‐of‐the‐art). More impressively, the integrated catheter allows for pulsed field ablation on the large animal heart through minimally invasive surgery and blocks the electrical conduction pathway on the heart, which is the key to treating atrial fibrillation. This catheter‐integrated device will enhance the efficiency and safety of pulsed field ablation, especially for complex cardiac structures, thus facilitating its move to the clinic.

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Section: Introductionmentioning

confidence: 99%

A High‐Precision, Low‐Voltage Pulsed Field Ablation Device with Capability of Minimally Invasive Surgery

Song

Hong

et al. 2023

Adv Funct Materials

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“…Most of the finger structures of IDEs reported so far have a rectangular cross-section, and most studies in this area have focused on the effects of the finger's width, length, and period have been conducted [20,21]. Similarly, studies on IDEs used for electroporation have mainly concentrated on electrodes with a rectangular cross-section and various pulse settings (duration, total pulse number, frequency, voltage), but there has been no study on finger shape according to the authors' knowledge [13,[22][23][24]. Therefore, further improvement in IDEs to enhance the electric field strength is required to increase the practicability of catheter-based IRE.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Electrical Injury Using Triangular Interdigitated Electrodes for Catheter-Based Irreversible Electroporation

Lee

Kim

2023

Applied Sciences

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Irreversible electroporation (IRE) is a promising nonthermal ablation technique that uses high-voltage electrical pulses to create permanent pores in the cell membrane of target tissue. Recently, endoscopic IRE with catheter-based electrodes has attracted significant attention as a potential alternative tool for gastrointestinal tumors, but it has been challenged owing to the limited electric field distribution in an in-plane electrode configuration, in which rectangular interdigitated electrodes (IDEs) are commonly used. Herein, we report an enhanced electrical injury in tissue using triangular IDEs that cause strong electric fields to be induced at the tip of the electrode fingers. A set of 10 pulses with a duration of 100 μs and a frequency of 1 Hz were delivered to the tissue, and a finite element method was used to calculate the electrical injury in the gastrointestinal model. The probability of cell death by electrical injury at the triangular IDEs increases by approximately 10 times compared to that of conventional rectangular IDEs at the same electrode distance. These results could potentially pave the way toward designing electrodes in catheter-based IRE devices.

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Dual-mode arrayed vibration-wind piezoelectric energy harvester

Xu,

Long,

Tian

et al. 2025

Energy Conversion and Management

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Multifunctional Microelectrode for Low-Voltage Pulsed Field Ablation in Atrial Fibrillation

Cited by 4 publications

References 28 publications

A High‐Precision, Low‐Voltage Pulsed Field Ablation Device with Capability of Minimally Invasive Surgery

A High‐Precision, Low‐Voltage Pulsed Field Ablation Device with Capability of Minimally Invasive Surgery

Enhanced Electrical Injury Using Triangular Interdigitated Electrodes for Catheter-Based Irreversible Electroporation

Dual-mode arrayed vibration-wind piezoelectric energy harvester

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