Multifunctional nanocomposite based on lactose@layered double hydroxide-hydroxyapatite as a pH-sensitive system for targeted delivery of doxorubicin to liver cancer cells

Mohammadzadeh, Vahid; Norouzi, Amin; Ghorbani, Marjan

doi:10.1016/j.colsurfa.2022.129723

Cited by 12 publications

(6 citation statements)

References 53 publications

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“…Ghorbani et al designed lactosefunctionalized MgAlCa-LDH for loading DOX (DOX/ Lactose@LDH-HAp) for DOX uptake by tumor cells. [109] Compared to DOX@LDH-HAp, this system exhibited more significant cellular uptake and tumor penetration, resulting in superior anti-tumor efficacy. Sun's research group prepared FA-modified CoAl-LDH and manganese dioxide self-assembled nanocarriers (FA-CM), which were not only able to be effectively degraded to Co 2 + , Al 3 + and Mn 2 + in the tumor environment.…”

Section: Chemotherapymentioning

confidence: 99%

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Advances of Layered Double Hydroxide‐Based Materials for Tumor Imaging and Therapy

Ma,

Chen,

Qiao

2024

The Chemical Record

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Layered double hydroxides (LDH) are a class of functional anionic clays that typically consist of orthorhombic arrays of metal hydroxides with anions sandwiched between the layers. Due to their unique properties, including high chemical stability, good biocompatibility, controlled drug loading, and enhanced drug bioavailability, LDHs have many potential applications in the medical field. Especially in the fields of bioimaging and tumor therapy. This paper reviews the research progress of LDHs and their nanocomposites in the field of tumor imaging and therapy. First, the structure and advantages of LDH are discussed. Then, several commonly used methods for the preparation of LDH are presented, including co‐precipitation, hydrothermal and ion exchange methods. Subsequently, recent advances in layered hydroxides and their nanocomposites for cancer imaging and therapy are highlighted. Finally, based on current research, we summaries the prospects and challenges of layered hydroxides and nanocomposites for cancer diagnosis and therapy.

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Section: Chemotherapymentioning

confidence: 99%

“…Ghorbani et al. designed lactose‐functionalized MgAlCa‐LDH for loading DOX (DOX/Lactose@LDH‐HAp) for DOX uptake by tumor cells [109] . Compared to DOX@LDH‐HAp, this system exhibited more significant cellular uptake and tumor penetration, resulting in superior anti‐tumor efficacy.…”

Section: Therapymentioning

confidence: 99%

Advances of Layered Double Hydroxide‐Based Materials for Tumor Imaging and Therapy

Ma,

Chen,

Qiao

2024

The Chemical Record

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“…Several recent studies have analyzed and enhanced the LDH-based delivery of therapeutic molecules [ 5 , 53 ], anti-inflammatory drugs [ 54 , 55 ], anticancer drugs [ 27 , 56 , 57 , 58 , 59 , 60 ], and peptide hormones [ 61 ] by improving the drug-release property of LDHs by modification via intercalation, absorption, and other methods. For example, a publication reported the intercalation of nicotinic acid (NA) in LDH interlayers [ 5 ].…”

Section: Design Of Functional Ldh Nanohybrids For Drug Deliverymentioning

confidence: 99%

“…This system, enabling the controlled delivery and release of MTX, exhibits high potential for application in colon-specific therapies involving oral administration. The drug-release performance and target-specific binding of these coated systems can be modulated using different ligands (for example, galactose or lactose is used for liver-tumor therapy [ 53 , 60 ], and dextran sulfate is used for actively identifying specific macrophage scavenger receptors [ 58 ]).…”

Section: Design Of Functional Ldh Nanohybrids For Drug Deliverymentioning

confidence: 99%

“…Ghorbani’s group have reported a similar in-vitro cell study analyzing the biological activity of DOX against the liver-cancer cell line HepG2, as shown in Figure 4 d [ 60 ], using hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , HAp), a cancer drug-delivery molecule, as a unique surface modifying agent for cancer treatment. HAp incorporation increases the LDH surface area and pore size, facilitating a higher DOX loading than that of unmodified LDH.…”

Section: Design Of Functional Ldh Nanohybrids For Drug Deliverymentioning

confidence: 99%

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Multifunctional Layered Double Hydroxides for Drug Delivery and Imaging

Choi

2023

Nanomaterials

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Two-dimensional nanomaterials, particularly layered double hydroxides (LDHs), have been widely applied in the biomedical field owing to their biocompatibility, biodegradability, controllable drug release/loading ability, and enhanced cellular permeability. Since the first study analyzing intercalative LDHs in 1999, numerous studies have investigated their biomedical applications, including drug delivery and imaging; recent research has focused on the design and development of multifunctional LDHs. This review summarizes the synthetic strategies and in-vivo and in-vitro therapeutic actions and targeting properties of single-function LDH-based nanohybrids and recently reported (from 2019 to 2023) multifunctional systems developed for drug delivery and/or bio-imaging.

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