Multifunctional Nanoparticles Possessing A “Magnetic Motor Effect” for Drug or Gene Delivery

Abstract

Cells in motion: Multifunctional nanoparticles, with a unique combination of magnetic and fluorescent properties, coupled with biocompatibility are prepared. The uptake of the magnetic nanoparticles by cells is investigated, and an external “magnetic motor effect” on the cells containing the nanoparticles is observed (see scheme).

Cytotoxicity and DNA Damage Induced by Magnetic Nanoparticle Silica in L5178Y Cell

“…nanoparticles were found to induce oxidative stress indicated by induction of reactive oxygen species generation, and membrane lipid peroxidation (Akhtar et al, 2010), and the toxicity were confi rmed in recent studies (Nabeshi et al, 2010;Yang et al, 2010;Ye et al, 2010). It seems that these discrepancy of toxicities may be associated with nano characteristics such as size, shape, surface chemistry and degree of aggregation infl uenced the production of free radicals and oxidative stress (Aillon et al, 2009 (Yoon et al, 2005;. Even magnetic silica nanoparticle can have wide applications in diagnosis, imaging and drug delivery, possible cytotoxicity and genotoxicity are not fully assessed.…”

“…They were prepared by the method as reported previously (Yoon et al, 2005). Analyses of size, component and inducing radical of synthetic MNP@SiO 2 were carried out from 0 to 48 h by transmission electron microscope (TEM), inductively coupled plasma-atomic emission spectrometer (ICP-AES) and electron spin resonance spectrometer (ESR), respectively.…”

Synthesis and Characterization of AICAR and DOX Conjugated Multifunctional Nanoparticles as a Platform for Synergistic Inhibition of Cancer Cell Growth

“…To construct the nanoparticles, silica (SiO 2 ) was used for surface coating of F 3 O 4 particles because dye molecules can be easily incorporated into a silica shell, and silica is quite biocompatible and resistant to biodegradation in biological environments. 24 In addition, silica can be easily surface functionalized for bioconjugation and targeted for various applications in biological systems. Hence, in this study we first synthesized bifunctional nanoparticles, F 3 O 4 @ SiO 2 (FITC) (Figure 1) with both fluorescent and magnetic properties by sol−gel formation of the silica layer onto the magnetite surface.…”

Polymeric nanoparticles for optical sensing

“…These NPs were internalized into living cells, allowing them to be both fluorescently and magnetically labeled. Interestingly, by application of an external magnetic field the labeled cells could also be actively moved (a process named the "magnetic motor effect"), without any apparent acute toxicity (Yoon et al, 2005). Apart from simultaneous cell separation and imaging purposes, this system might find applications in the magnetic delivery of drugs within cells.…”