Multifunctional nanoprobe for multi-mode imaging and diagnosis of metastatic prostate cancer

Wang, Ze; Liu, Annan; Li, Xingchen; Guan, Lin; Xing, Huiyuan; He, Liang; Fang, Linan; Zvyagin, Andrei V.; Yang, Xiao‐Yu; Yang, Bai; Lin, Quan

doi:10.1016/j.talanta.2023.124255

Cited by 11 publications

(12 citation statements)

References 45 publications

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“…The limitations of single-modality imaging pose a significant challenge for healthcare providers because the current ability to use distinct methods to detect PCa and its metastases in patients is inadequate. To overcome this limitation, Wang et al 48 developed a targeted therapeutic diagnostic platform for PCa multimodality imaging-guided photothermal therapy utilizing an Au/Mn nanodot-luteinizing hormone-releasing hormone (AMNDs-LHRH) nanosystem. This system can precisely target both gonadotropin-releasing hormone receptor (GnRH-R)-positive PCa and metastasis for precise preoperative CT/MR diagnosis while enabling fluorescence (FL) visualization to guide surgical intervention, showing its promise in clinical cancer detection and surgical guidance.…”

Section: Ct/mr Multimodal Nano-contrast Agent Researchmentioning

confidence: 99%

Advances in nanotechnology-based targeted-contrast agents for computed tomography and magnetic resonance

Lai,

Luo,

Chen

et al. 2024

Science Progress

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X-ray computed tomography (CT) and magnetic resonance (MR) imaging are essential tools in modern medical diagnosis and treatment. However, traditional contrast agents are inadequate in the diagnosis of various health conditions. Consequently, the development of targeted nano-contrast agents has become a crucial area of focus in the development of medical image-enhancing contrast agents. To fully understand the current development of nano-contrast agents, this review provides an overview of the preparation methods and research advancements in CT nano-contrast agents, MR nano-contrast agents, and CT/MR multimodal nano-contrast agents described in previous publications. Due to the physicochemical properties of nanomaterials, such as self-assembly and surface modifiability, these specific nano-contrast agents can greatly improve the targeting of lesions through various preparation methods and clearly highlight the distinction between lesions and normal tissues in both CT and MR. As a result, they have the potential to be used in the early stages of disease to improve diagnostic capacity and level in medical imaging.

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Section: Ct/mr Multimodal Nano-contrast Agent Researchmentioning

confidence: 99%

Advances in nanotechnology-based targeted-contrast agents for computed tomography and magnetic resonance

Lai,

Luo,

Chen

et al. 2024

Science Progress

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“…In contrast, the PBS group showed minimal changes, further confirming the potential of AMNDs-LHRH as a promising candidate for tumor photothermal therapy (PTT). 206 Dai et al 181 designed a multi-functional nanoparticle based on mesoporous polydopamine (MPDA) for the targeted delivery of DTX in coordination with chemical photothermal treatment of prostate cancer. DTX was embedded in the mesopore with a high loading of MPDA, and the particles were then modified with AS1411 to target prostate cancer cells.…”

Section: Ptt In the Treatment Of Prostate Cancermentioning

confidence: 99%

Photothermal therapy: a novel potential treatment for prostate cancer

Dong,

Xue,

Verma

et al. 2024

Biomater. Sci.

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“…CT imaging offers high spatial resolution and fast detection speed, making it advantageous . However, its application in soft tissue imaging is limited by its lack of sensitivity. , Furthermore, conventional contrast agents like iodine present issues of toxicity and side effects . On the other hand, FL imaging shows promise as an intuitive and sensitive modality for disease monitoring and surgical guidance.…”

Section: Introductionmentioning

confidence: 99%

Advancing Spinal Cord Injury Bioimaging and Repair with Multifunctional Gold Nanodots Tracking

Wang,

Shen,

Liu

et al. 2024

ACS Appl. Mater. Interfaces

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High levels of reactive oxygen species (ROS) are known to play a critical role in the secondary cascade of spinal cord injury (SCI). The scavenging of ROS has emerged as a promising approach for alleviating acute SCI. Moreover, identifying the precise location of the SCI site remains challenging. Enhancing the visualization of the spinal cord and improving the ability to distinguish the lesion site are crucial for accurate and safe treatment. Therefore, there is an urgent clinical need to develop a biomaterial that integrates diagnosis and treatment for SCI. Herein, ultra-small-sized gold nanodots (AuNDs) were designed for dual-mode imaging-guided precision treatment of SCI. The designed AuNDs demonstrate two important functions. First, they effectively scavenge ROS, inhibit oxidative stress, reduce the infiltration of inflammatory cells, and prevent apoptosis. This leads to a significant improvement in SCI repair and promotes a functional recovery after injury. Second, leveraging their excellent dual-mode imaging capabilities, the AuNDs enable rapid and accurate identification of SCI sites. The high contrast observed between the injured and adjacent uninjured areas highlights the tremendous potential of AuNDs for SCI detection. Overall, by integrating ROS scavenging and dual-mode imaging in a single biomaterial, our work on functionalized AuNDs provides a promising strategy for the clinical diagnosis and treatment of SCI.

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Multifunctional nanoprobe for multi-mode imaging and diagnosis of metastatic prostate cancer

Cited by 11 publications

References 45 publications

Advances in nanotechnology-based targeted-contrast agents for computed tomography and magnetic resonance

Advances in nanotechnology-based targeted-contrast agents for computed tomography and magnetic resonance

Photothermal therapy: a novel potential treatment for prostate cancer

Advancing Spinal Cord Injury Bioimaging and Repair with Multifunctional Gold Nanodots Tracking

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