Multifunctional near-infrared fluorescent nanoclusters for simultaneous targeted cancer imaging and photodynamic therapy

The development of fluorescence turn-on probe for Al(III) sensing and live cell nucleus-nucleoli staining

“…There are few reports on specific staining of nucleus by employing nano-materials 21 and Ir(III) 14 / Ru(II) 15 complexes to different cell lines. Specific staining of nucleolus is also achieved using carbon based nano-materials 22 , nanoclusters 23 , coumarin and pyronin based moieties 24 25 , Eu(III) 26 /Ir(III) 27 complexes and semiconducting quantum dots 28 . Two water soluble molecules containing N-methyl benzothiazolium moiety are recently reported which individually stains nucleus and nucleolus 29 .…”

Metallic Nanoclusters for Cancer Imaging and Therapy

“…MCF-7 breast cancer cells possessed good uptake for BSA-Ag 13 NCs and were efficiently killed due to the irradiation of white light via PDT. Wang et al [126] prepared water-soluble Ag NCs encapsulated by a DNA scaffold, which displayed NIR fluorescence and photothermal effect. Moreover, AS1411, a nucleoli-targeting agent, was connected with the DNA scaffold and the protoporphyrin IX (PPIX) was captured by AS1411.…”

PVP‐templated novel fluorescent Ag nanomaterials synthesis and its application to bioimaging

“…Surface reactivity and optical properties are enhanced by the high surface energy of nanostructures leading to their application in the chemical and electronic industries. Cancer is still one of the most causes of mortality in the world to date though rapid advances have been made in the diagnostic and therapeutic methods [12–14]. Exploration of novel approaches with accurate tumour detection and targeted therapy is extremely urgent [15].…”