Multifunctional NO-delivery vessel derived from aminopropyl-modified mesoporous zeolites

Feng, Wei; Hou, Qian; Yang, Jincai; Zhu, Jian Hua

doi:10.1016/j.jcis.2011.01.019

Cited by 16 publications

(8 citation statements)

References 51 publications

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“…The shape of the nanomaterial has also been explored using both spherical and nonspherical particles, where the latter seems to have superior features in many aspects of the drug delivery process . In addition to that, MSNs have already a well-described chemistry and functionalization strategies that can be used as potential drug delivery platforms. − …”

Section: Introductionmentioning

confidence: 99%

“…Having those approaches in mind, a few groups have designed new materials based on silica to create a suitable environment for vasodilator drugs such as SNP or analogues while maintaining their capacity to release NO. , Farooq et al prepared an interesting material, where they incorporated SNP onto a fluorescent mesoporous silica matrix as a delivery system. In that study, ex vivo real-time vasodilator action of SNP on arterial vessels was reported for the first time.…”

Section: Introductionmentioning

confidence: 99%

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Incorporation of Nitroprusside on Silica Nanoparticles—A Strategy for Safer Use of This NO Donor in Therapy

et al. 2019

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Silica-based nanoparticles have been developed as powerful platforms for drug delivery and might also prevent undesired side effects of drugs. Here, a fast method to synthesize positively charged mesoporous silica nanoparticles (ζ = 20 ± 0.5 mV, surface area = 678 m 2 g −1 , and 2.3 nm of porous size) was reported. This nanomaterial was employed to anchor sodium nitroprusside (SNP), a vasodilator drug with undesired cyanide release. A remarkable incorporation of 323.9 ± 7.55 μmol of SNP per gram of nanoparticle was achieved, and a series of studies of NO release were conducted, showing efficient release of NO along with major cyanide retention (ca. 64% bound to nanoparticle). Biological assays with mammalian cells showed only a slight drop in cell viability (13%) at the highest concentration (1000 μM), while SNP exhibited an LC 50 of 228 μM. Moreover, pharmacological studies demonstrated similar efficacy for vasodilation and sGC-PKG-VASP pathway activation when compared to SNP alone. Altogether, this new SNP silica nanoparticle has great potential as an alternative for wider and safer use of SNP in medicine with lower cyanide toxicity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Incorporation of Nitroprusside on Silica Nanoparticles—A Strategy for Safer Use of This NO Donor in Therapy

et al. 2019

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“…An alternative moiety being able to store and deliver NO are the amine groups, which can store NO in the form of nitrite and release it under acidic conditions. To immobilize the amine functionality on the surface of mesoporous silica, γaminopropyltriethoxysilane (APTES) was attached on the surface of MCM-41 and mesoporous MFI zeolite, 63 which was synthesized from MCM-41 by dry-gel conversion. 64 Before the modification of APTES, NO was loaded on MCM-41 and MFI zeolite.…”

Section: Chemical Attachment Of Gas Donorsmentioning

confidence: 99%

Lateral flow assay modified with time-delay wax barriers as a sensitivity and signal enhancement strategy

Sena‐Torralba

Ngo

Parolo

et al. 2020

Biosensors and Bioelectronics

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The discovery of NO, CO, and H2S as gasotransmitters and their beneficial role in multiple physiological functions opened an era of research devoted to exogenously deliver them as therapeutic agents. However, the gaseous nature of these molecules demands new forms of administration that enable to control the location, dosage and timing of their delivery. Porous materials are among the most suitable scaffolds to store, deliver and release gasotranmistters due to their high surface area, tunable composition and reactivity. This review highlights the strategies employed to load and release gasotransmitters from different kinds of porous materials, including zeolites, mesoporous silica, metal-organic frameworks and protein assemblies.

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Section: Chemical Attachment Of Gas Donorsmentioning

confidence: 99%

Porous materials as carriers of gasotransmitters towards gas biology and therapeutic applications

et al. 2020

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Multifunctional NO-delivery vessel derived from aminopropyl-modified mesoporous zeolites

Cited by 16 publications

References 51 publications

Incorporation of Nitroprusside on Silica Nanoparticles—A Strategy for Safer Use of This NO Donor in Therapy

Incorporation of Nitroprusside on Silica Nanoparticles—A Strategy for Safer Use of This NO Donor in Therapy

Lateral flow assay modified with time-delay wax barriers as a sensitivity and signal enhancement strategy

Porous materials as carriers of gasotransmitters towards gas biology and therapeutic applications

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