Multifunctional PLGA particles containing poly(l-glutamic acid)-capped silver nanoparticles and ascorbic acid with simultaneous antioxidative and prolonged antimicrobial activity

Stevanović, Magdalena; Bračko, Ines; Milenković, Marina; Filipović, Nenad; Nunić, Jana; Filipič, Metka; Uskoković, Dragan

doi:10.1016/j.actbio.2013.08.030

Cited by 82 publications

(48 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Organization and Food and Drug Administration and are very often used as materials in medicine and pharmacy as polymeric prodrugs, for drug delivery or therapeutic systems [22,23]. They have numerous A c c e p t e d M a n u s c r i p t advantages, such as excellent processing characteristics, degradation rates that can be tailored for the intended application, as well as exhibiting unique pharmacokinetics and pharmacological efficacy [23].…”

Section: Introductionmentioning

confidence: 99%

“…They have numerous A c c e p t e d M a n u s c r i p t advantages, such as excellent processing characteristics, degradation rates that can be tailored for the intended application, as well as exhibiting unique pharmacokinetics and pharmacological efficacy [23]. PLGA micro and nanoparticles are used for the controlled delivery of several classes of medicaments such as anticancer agents, growth factors, antibiotics, antimicrobial agents, etc [24].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

45S5Bioglass®-based scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium particles: Processing, evaluation and antibacterial activity

Stevanović

Filipović

Djurdjevic

et al. 2015

Colloids and Surfaces B: Biointerfaces

Self Cite

View full text Add to dashboard Cite

In the bone tissue engineering field, there is a growing interest in the application of bioactive glass scaffolds (45S5Bioglass(®)) due to their bone bonding ability, osteoconductivity and osteoinductivity. However, such scaffolds still lack some of the required functionalities to enable the successful formation of new bone, e.g. effective antibacterial properties. A large number of studies suggest that selenium (Se) has significant role in antioxidant protection, enhanced immune surveillance and modulation of cell proliferation. Selenium nanoparticles (SeNp) have also been reported to possess antibacterial as well as antiviral activities. In this investigation, uniform, stable, amorphous SeNp have been synthesized and additionally immobilized within spherical PLGA particles (PLGA/SeNp). These particles were used to coat bioactive glass-based scaffolds synthesized by the foam replica method. Samples were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and transmission electron microscopy (TEM). SeNp, 45S5Bioglass(®)/SeNp and 45S5Bioglass(®)/PLGA/SeNp showed a considerable antibacterial activity against Gram positive bacteria, Staphylococcus aureus and Staphylococcus epidermidis, one of the main causative agents of orthopedic infections. The functionalized Se-coated bioactive glass scaffolds represent a new family of bioactive, antibacterial scaffolds for bone tissue engineering applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

45S5Bioglass®-based scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium particles: Processing, evaluation and antibacterial activity

Stevanović

Filipović

Djurdjevic

et al. 2015

Colloids and Surfaces B: Biointerfaces

Self Cite

View full text Add to dashboard Cite

show abstract

“…[21][22][23][24] In fact, PLGA hydrolysis leads to endogenous and easily metabolized molecules (lactic and glycolic acids), and PLGA has been approved by the US Food and Drug Administration and the European Medicine Agency in a series of drug delivery systems for human use. Poly(lactic-co-glycolic acid) (PLGA) is one of the most widely used biodegradable and biocompatible materials for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Au nanoparticle-coated, PLGA-based hybrid capsules for combined ultrasound imaging and HIFU therapy

Qian

et al. 2015

J. Mater. Chem. B

View full text Add to dashboard Cite

Herein, we present a simple method to prepare Au nanoparticle-coated, polydopamine-modified poly(lactic-co-glycolic acid) (AuNPs@PDA/PLGA) hybrid capsules for combined ultrasound imaging and high-intensity focused ultrasound (HIFU) therapy. In this approach, PLGA nanocapsules are prepared firstly via a facile and efficient water/oil/water (W/O/W) emulsion strategy, and are then modified with PDA through the self-polymerization of dopamine in a weakly alkaline aqueous environment. Subsequently, chloroauric acid (HAuCl 4 ) solution is added, and AuCl 4 À ions are absorbed on the surfaces of the PDA/ PLGA nanocapsules by the active catechol and amine groups of PDA coatings. Finally, these absorbed AuCl 4 À ions are reduced in situ to AuNPs to form AuNPs@PDA/PLGA hybrid capsules. The in vitroultrasound imaging experiments show that AuNPs@PDA/PLGA hybrid capsules are suitable for ultrasound contrast imaging. Moreover, the potential of the nanocapsules to enhance HIFU therapy is also demonstrated. These results show that ultrasound-guided HIFU therapy ex vivo with AuNPs@PDA/PLGA hybrid capsules is highly efficient on degassed bovine livers due to the high thermal energy accumulation of AuNPs. Thus, the successful integration of the AuNPs and PLGA nanocapsules provides an alternative strategy for highly efficient ultrasound-guided HIFU therapy.

show abstract

“…The as‐prepared pure PLGA membrane (Figure (a)) shows smooth surface which then formed micropores (Figure (b) and (c)) over 12 weeks of immersion in both solutions. The microporous matrix creation was corresponding to the onset bulk degradation of the PLGA polymer …”

Section: Introductionmentioning

confidence: 99%

The in Vitro Degradation of PLGA/Nanoapatite/Lauric Acid Composite Membrane: A Comparative Study in Phosphate Buffer Saline and Simulated Body Fluid

Jamuna-Thevi

Suleiman

Sabri

2017

Macromolecular Symposia

View full text Add to dashboard Cite

Summary The aim of this study was to examine the effect of ionic content of immersion medium on the degradation of PLGA based composite membranes intended for guided bone regeneration applications. The in vitro degradation of pure poly(lactic‐co‐glycolic acid) (PLGA) membranes and PLGA/nanoapatite (NAp)/lauric acid (LA) graded composite membranes was studied for 12 weeks in two types of immersion mediums, i.e., phosphate buffer saline (PBS) and simulated body fluid (SBF) at 37°C with a controlled pH condition at 7.4. A comparative immersion study between PBS and SBF showed weight loss in PBS soaked composite membranes whereas a continuous weight gain was observed in SBF soaked membranes due to induction of calcium phosphate minerals as evidenced in the scanning electron microscopy (SEM) analysis. The apatite mineralisation on SBF soaked membrane surfaces reflects its excellent in vitro bone bioactivity. The new apatite mineralisation on composite membrane surfaces is referred to the possible positive impact in vivo for new bone regeneration. Hence, it can be concluded that SBF is a closely mimicking physiological environment that enables one to fine‐tune the genuine degradation behavior of membranes compared to PBS for potential clinical applications.

show abstract

Multifunctional PLGA particles containing poly(l-glutamic acid)-capped silver nanoparticles and ascorbic acid with simultaneous antioxidative and prolonged antimicrobial activity

Cited by 82 publications

References 55 publications

45S5Bioglass®-based scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium particles: Processing, evaluation and antibacterial activity

45S5Bioglass®-based scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium particles: Processing, evaluation and antibacterial activity

Au nanoparticle-coated, PLGA-based hybrid capsules for combined ultrasound imaging and HIFU therapy

The in Vitro Degradation of PLGA/Nanoapatite/Lauric Acid Composite Membrane: A Comparative Study in Phosphate Buffer Saline and Simulated Body Fluid

Contact Info

Product

Resources

About