Multifunctional poly(aspartic acid) nanoparticles containing iron oxide nanocrystals and doxorubicin for simultaneous cancer diagnosis and therapy

Yang, Hee‐Man; Oh, Byung Chang; Ahn, Taebin; Nam, Ho-Seong; Park, Chan Woo; Kim, Jong-Duk

doi:10.1016/j.colsurfa.2011.04.032

Cited by 37 publications

(15 citation statements)

References 25 publications

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“…They have been used as catalyst, adsorbents for organic or inorganic polluents, 1,2 as electrodes in batteries, 3 and for bioapplications. 4 In particular, magnetic iron oxides show interesting responses to external magnetic fields, which are suitable for clinical diagnosis, medical therapy, 5 and magnetic separation. 6 Generally, nano-sized materials exhibit novel physical and chemical properties, and consequently the synthesis of nanostructured iron oxides particles was intentionally studied.…”

Section: Introductionmentioning

confidence: 99%

Nanometric particle size and phase controlled synthesis and characterization of γ-Fe2O3 or (α + γ)-Fe2O3 by a modified sol-gel method

Silva

Oliveira

Ciciliati

et al. 2013

Journal of Applied Physics

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Fe 2 O 3 nanoparticles with sizes ranging from 15 to 53 nm were synthesized by a modified sol-gel method. Maghemite particles as well as particles with admixture of maghemite and hematite were obtained and characterized by XRD, FTIR, UV-Vis photoacoustic and M€ ossbauer spectroscopy, TEM, and magnetic measurements. The size and hematite/maghemite ratio of the nanoparticles were controlled by changing the Fe:PVA (poly (vinyl alcohol)) monomeric unit ratio used in the medium reaction (1:6, 1:12, 1:18, and 1:24). The average size of the nanoparticles decreases, and the maghemite content increases with increasing PVA amount until 1:18 ratio. The maghemite and hematite nanoparticles showed cubic and hexagonal morphology, respectively. Direct band gap energy were 1.77 and 1.91 eV for A6 and A18 samples. Zero-field-cooling-field-cooling curves show that samples present superparamagnetic behavior. Maghemite-hematite phase transition and hematite N eel transition were observed near 700 K and 1015 K, respectively. Magnetization of the particles increases consistently with the increase in the amount of PVA used in the synthesis. M€ ossbauer spectra were adjusted with a hematite sextet and maghemite distribution for A6, A12, and A24 and with maghemite distribution for A18, in agreement with XRD results. V

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Section: Introductionmentioning

confidence: 99%

Nanometric particle size and phase controlled synthesis and characterization of γ-Fe2O3 or (α + γ)-Fe2O3 by a modified sol-gel method

Silva

Oliveira

Ciciliati

et al. 2013

Journal of Applied Physics

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“…10 Several SPIO/POLYMER/DOX composites have been developed and tested for their drug releasing properties at various pH values, temperature, or in the presence of external magnetic fields, followed by cell internalization studies and measurement of common cytotoxic assays. 5,9,[11][12][13][14] Cancer is ranked among the leading causes of death worldwide, accounting for 8.2 million deaths in 2012. Given the predicted annual rate of increase in diagnosed cancer cases from 14 million in 2012 to 22 million within the next two decades (Globocan 2012, IARC), the need for effective and progressive cancer therapy is a priority in today's research.…”

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confidence: 99%

In vitro cytotoxicity analysis of doxorubicin-loaded/superparamagnetic iron oxide colloidal nanoassemblies on MCF7 and NIH3T3 cell lines

Tománková¹,

Poláková²,

Pizova³

et al. 2015

IJN

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One of the promising strategies for improvement of cancer treatment is based on magnetic drug delivery systems, thus avoiding side effects of standard chemotherapies. Superparamagnetic iron oxide (SPIO) nanoparticles have ideal properties to become a targeted magnetic drug delivery contrast probes, named theranostics. We worked with SPIO condensed colloidal nanocrystal clusters (MagAlg) prepared through a new soft biomineralization route in the presence of alginate as the polymeric shell and loaded with doxorubicin (DOX). The aim of this work was to study the in vitro cytotoxicity of these new MagAlg–DOX systems on mouse fibroblast and breast carcinoma cell lines. For proper analysis and understanding of cell behavior after administration of MagAlg–DOX compared with free DOX, a complex set of in vitro tests, including production of reactive oxygen species, comet assay, cell cycle determination, gene expression, and cellular uptake, were utilized. It was found that the cytotoxic effect of MagAlg–DOX system is delayed compared to free DOX in both cell lines. This was attributed to the different mechanism of internalization of DOX and MagAlg–DOX into the cells, together with the fact that the drug is strongly bound on the drug nanocarriers. We discovered that nanoparticles can attenuate or even inhibit the effect of DOX, particularly in the tumor MCF7 cell line. This is a first comprehensive study on the cytotoxic effect of DOX-loaded SPIO compared with free DOX on healthy and cancer cell lines, as well as on the induced changes in gene expression.

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“…Polyaspartic acid (PAsp) nanoparticles containing iron oxide nanocrystals and Dox have been prepared for cancer diagnosis and therapy. 41 Iron oxide nanocrystals synthesized by the thermal decomposition method were incorporated into PAsp nanoparticles through an emulsion method. Dox, was incorporated into the PAsp nanoparticles via a solvent diffusion method for cancer therapy application.…”

Section: Nanocrystalsmentioning

confidence: 99%

Cancer research and therapy: Where are we today?

Sawant

Shegokar

2014

Int J Cancer Ther Oncol

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Till date scientists are struggling to understand the complete mechanism of carcinogenesis. In future, the real time detection of cancer may help scientists to identify some of the complicated biological mechanisms. Certain special features of cancer cells enable researchers to deliver the drug or to develop the right drug therapy. These cell properties include over expression or over activity in uptake of certain nutrients e.g. folic acid and increased permeability. Listed properties might vary depending upon the type of cancer and can be fully exploited by using nanoparticles either to detect the site of cancer or to direct the drug at the affected site. Product approach like drug conjugates, complexes serves as a good platform to solve issues like solubility, toxicity, poor penetration and stability related to cancer drugs. Beside this, several drug delivery platforms are under development by researchers in academia as well as in industry to deliver therapeutic molecules and new chemical entities to the targeted site in body. Amongst them, nanotechnology both at molecular and supramolecular level is a leading platform and can help to image, detect and treat cancer. Surface modification of nanoparticles by coating or anchoring their surface with special markers, materials, peptide, proteins, antibodies or antigens add extra feature and thereby can enhance the effectiveness. These treatments can be used individually or in combined form. In this review, advances on nanotechnological platform are discussed together with some assisting techniques like magnetic field, photo or light field, sonic rays are touched upon. New biological therapies that are advancing in this direction include the antisense therapy, cell therapy, gene therapy, radiation therapy and SiRNA interfaces which are discussed in brief in this article. This article gives short overview on use of complementary and alternative medicine for treatment of cancer such as traditional Chinese medicine (TCM), Ayurveda to avoid toxic effects of synthetic drugs.

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Multifunctional poly(aspartic acid) nanoparticles containing iron oxide nanocrystals and doxorubicin for simultaneous cancer diagnosis and therapy

Cited by 37 publications

References 25 publications

Nanometric particle size and phase controlled synthesis and characterization of γ-Fe2O3 or (α + γ)-Fe2O3 by a modified sol-gel method

Nanometric particle size and phase controlled synthesis and characterization of γ-Fe2O3 or (α + γ)-Fe2O3 by a modified sol-gel method

In vitro cytotoxicity analysis of doxorubicin-loaded/superparamagnetic iron oxide colloidal nanoassemblies on MCF7 and NIH3T3 cell lines

Cancer research and therapy: Where are we today?

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