Multifunctional porous silicon nanoparticles for cancer theranostics

Wang, Chang-Fang; Sarparanta, Mirkka; Mäkilä, Ermei; Hyvönen, Mervi T.; Laakkonen, Pirjo; Salonen, Jarno; Hirvonen, Jouni; Airaksinen, Anu J.; Santos, Hélder A.

doi:10.1016/j.biomaterials.2015.01.008

Cited by 148 publications

(103 citation statements)

References 48 publications

(46 reference statements)

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“…Although there is not a lot of data about the application of other metalloid NPs in medicine in cancer research in particular, to the best of the authors' knowledge, boron NPs have been used for different diagnosis or therapeutic purposes in cancer models [160,161], but other metalloid NPs such as germanium are frequently used in other areas of nanotechnology. Silicon NPs are also well-known as quantum dot (QD) agents and typically used for diagnostic systems [162]. Despite toxicity concerns about arsenic, arsenic trioxide (As 2 O 3 ) NPs have recently been considered a promising anticancer agent for solid tumors [143,163].…”

Section: Metalloid Nanoparticles and Cancermentioning

confidence: 99%

Metal, Metalloid, and Oxide Nanoparticles for Therapeutic and Diagnostic Oncology

Yazdi¹,

Sepehrizadeh²,

Mahdavi³

et al. 2016

Nano BioMed ENG

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Nanoparticles have comprehensively affected various sights of human life. Through the wide range of claims about nanosized particles and their functions, biomedical applications are of much interest among health care researchers due to the nanoparticles' potential for use in the process of disease diagnosis, control and treatment. In this regard, inorganic nanoparticles, which have high potential in diagnostic and therapeutic systems, have recently received much attention in oncology. Although inorganic nanoparticles initially seemed an appropriate tool for cancer imaging and diagnosis, their ability to attack cancerous cells as anticancer drugs or carriers in other drugs has also demonstrated promising results. The present review primarily provides a brief survey of various studies in which metal nanoparticles such as gold, silver, iron oxide, and metalloid nanoparticles viz. tellurium and bismuth were exploited for therapeutic or diagnostic purposes in oncology. Then the application of selenium nanoparticles as a therapeutic agent against cancer in in vitro and in vivo studies is reviewed in detail. Although inorganic nanoparticles seem to be useful tools for cancer imaging and diagnosis, their potential for attacking cancerous cells as anticancer substances or even carriers for anticancer medications should not be underestimated.

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Section: Metalloid Nanoparticles and Cancermentioning

confidence: 99%

Metal, Metalloid, and Oxide Nanoparticles for Therapeutic and Diagnostic Oncology

Yazdi¹,

Sepehrizadeh²,

Mahdavi³

et al. 2016

Nano BioMed ENG

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“…[67,68] Multifunctional receptor-targeted porous silicon (PSi) nanoparticles containing a RGD-targeting peptide, an anticancer agent, a fluorophore and 111 In have been used for tumor targeting and imaging combined with drug delivery in prostate cancer xenograft mouse model. [69] Similarly, targeted theranostic liposomes consisting of gadolinium and doxorubicin with peptide targeted to neural cell adhesion molecules showed high drug concentration in tumors, inhibiting the tumor growth with enhanced MRI imaging of Kaposi's tumours in mice. [70] Moreover, porous silica coated quantum dots loading doxorubicin can spontaneously achieve cathepsin B enzyme targeting drug release and real-time fluorescence imaging in lung carcinoma A549 cells.…”

Section: Third Generation Nanomedicinesmentioning

confidence: 99%

Bridging the Knowledge of Different Worlds to Understand the Big Picture of Cancer Nanomedicines

Balasubramanian

Liu

Hirvonen

et al. 2017

Adv Healthcare Materials

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Explosive growth of nanomedicines continues to significantly impact the therapeutic strategies for effective cancer treatment. Despite the significant progress in the development of advanced nanomedicines, successful clinical translation remains challenging. As cancer nanomedicine is a multidisciplinary field, the fundamental problem is that the knowledge gaps stem from different vantage points in the understanding of cancer nanomedicines. The complexities and heterogenecity of both nanomedicines and cancer are further demanding the integration of highly diverse expertise to develop clinically translatable cancer nanomedicines. This progress report aims to discuss the current understanding of cancer nanomedicines between different research areas in terms of nanoparticle engineering, formulation, tumor patho-physiology and clinical medicine, as well as to identify the knowledge gaps lying at the interface between the different fields of research in nanomedicine. Here we also highlight for the necessity to harmonize the multidisciplinary effort in the research of nanomedicines in order to bridge the knowledge and to advance the full understanding in cancer nanomedicines. A paradigm shift is needed in the strategic development of disease specific nanomedicines in order to foster the successful translation into clinic of future cancer nanomedicines.

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“…[16][17][18] In addition, such nanocarrier systems can be very benefi cial if multimodal features and charge modulation are also incorporated in them. [ 19 ] A typical system which can easily incorporate such multiple features are core-shell type nanocarriers. Surface chemistry of core templates in such systems plays crucial role in their design and synthesis.…”

mentioning

confidence: 99%

Bioinspired Oil Core/Silica Shell Nanocarriers with Tunable and Multimodal Functionalities

Jakhmola

Vecchione

Guarnieri

et al. 2015

Adv Healthcare Materials

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The application of multimodal systems in the field of nanomedicine is advantageous as they can perform two or more tasks simultaneously. Here a robust approach is presented mimicking biogenic silica to design a multilayered nanocarrier system with a central oil core encapsulated within a polymer-silica shell. The outermost silica shell has been deposited through a biosilicification process induced by poly-L-lysine molecules immobilized on the surface of emulsion droplets. This system can be simultaneously loaded with high amount of hydrophobic molecules or contrasting agents in the inner oil core, while the polymeric-silica layers can be easily tagged with at least two different contrasting agents. Additionally, the zwitterionic nature of the silica precipitating peptide (poly-L-lysine) has been efficiently exploited to modulate and entirely reverse the surface charge of the nanocarrier without using any additional coating material. It has been demonstrated experimentally that the designed nanocapsular system is monodisperse, nontoxic, cargo protective, tunable in thickness, fluorescent, and magnetic resonance imaging (MRI) active so highly versatile for multiple applications in the field of drug delivery and in vivo imaging.

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Multifunctional porous silicon nanoparticles for cancer theranostics

Cited by 148 publications

References 48 publications

Metal, Metalloid, and Oxide Nanoparticles for Therapeutic and Diagnostic Oncology

Metal, Metalloid, and Oxide Nanoparticles for Therapeutic and Diagnostic Oncology

Bridging the Knowledge of Different Worlds to Understand the Big Picture of Cancer Nanomedicines

Bioinspired Oil Core/Silica Shell Nanocarriers with Tunable and Multimodal Functionalities

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