Multifunctional silicon calcium phosphate composite scaffolds promote stem cell recruitment and bone regeneration

Zhang, Rui; Tao, Bailong; Wu, Jing; Hu, Xiaoye; Li, Xuan; Xia, Zengzilu; Cai, Kaiyong

doi:10.1039/d2tb00687a

Cited by 4 publications

(1 citation statement)

References 49 publications

(57 reference statements)

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“…Xu et al also reported that a moderate pro-inflammatory microenvironment in the early stages after scaffold implantation contributed to stem cell recruitment. Alternatively, cell recruitment could be promoted by local administration [141,142] or in situ expression [143] of chemoattractants that are responsible for cell homing, as well as by physical cues (e.g., magnetic field) [144]; see Figure 5 for a schematic illustration. A protein proven to be both chemoattractive to bone-forming cells and pivotal to the development and regeneration of cranium is bone morphogenic protein-2 (BMP-2) [46].…”

Section: Enhancing the Osteogenic Potential On The Scalp Sidementioning

confidence: 99%

Biomaterials for Regenerative Cranioplasty: Current State of Clinical Application and Future Challenges

2024

JFB

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Acquired cranial defects are a prevalent condition in neurosurgery and call for cranioplasty, where the missing or defective cranium is replaced by an implant. Nevertheless, the biomaterials in current clinical applications are hardly exempt from long-term safety and comfort concerns. An appealing solution is regenerative cranioplasty, where biomaterials with/without cells and bioactive molecules are applied to induce the regeneration of the cranium and ultimately repair the cranial defects. This review examines the current state of research, development, and translational application of regenerative cranioplasty biomaterials and discusses the efforts required in future research. The first section briefly introduced the regenerative capacity of the cranium, including the spontaneous bone regeneration bioactivities and the presence of pluripotent skeletal stem cells in the cranial suture. Then, three major types of biomaterials for regenerative cranioplasty, namely the calcium phosphate/titanium (CaP/Ti) composites, mineralised collagen, and 3D-printed polycaprolactone (PCL) composites, are reviewed for their composition, material properties, and findings from clinical trials. The third part discusses perspectives on future research and development of regenerative cranioplasty biomaterials, with a considerable portion based on issues identified in clinical trials. This review aims to facilitate the development of biomaterials that ultimately contribute to a safer and more effective healing of cranial defects.

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Section: Enhancing the Osteogenic Potential On The Scalp Sidementioning

confidence: 99%

Biomaterials for Regenerative Cranioplasty: Current State of Clinical Application and Future Challenges

2024

JFB

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Multifarious roles of metal elements in bone mineralization

Niu

Cao

et al. 2023

Applied Materials Today

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The Biomimetic Electrical Stimulation System Inducing Osteogenic Differentiations of BMSCs

Xia,

Zhang,

et al. 2024

ACS Appl. Mater. Interfaces

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Electrical stimulation has been used clinically as an adjunct therapy to accelerate the healing of bone defects, and its mechanism requires further investigations. The complexity of the physiological microenvironment makes it challenging to study the effect of electrical signal on cells alone. Therefore, an artificial system mimicking cell microenvironment in vitro was developed to address this issue. In this work, a novel electrical stimulation system was constructed based on polypyrrole nanowires (ppyNWs) with a high aspect ratio. Synthesized ppyNWs formed a conductive network in the composited hydrogel which contained modified gelatin with methacrylate, providing a conductive cell culture matrix for bone marrow mesenchymal stem cells. The dual-network conductive hydrogel had improved mechanical, electrical, and hydrophilic properties. It was able to imitate the three-dimensional structure of the cell microenvironment and allowed adjustable electrical stimulations in the following system. This hydrogel was integrated with cell culture plates, platinum electrodes, copper wires, and external power sources to construct the artificial electrical stimulation system. The optimum voltage of the electrical stimulation system was determined to be 2 V, which exhibited remarkable biocompatibility. Moreover, this system had significant promotion in cell spreading, osteogenic makers, and bone-related gene expression of stem cells. RNA-seq analysis revealed that osteogenesis was correlated to Notch, BMP/Smad, and calcium signal pathways. It was proven that this biomimetic system could regulate the osteogenesis procedure, and it provided further information about how the electrical signal regulates osteogenic differentiations.

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Multifunctional silicon calcium phosphate composite scaffolds promote stem cell recruitment and bone regeneration

Abstract: Scaffold is one of the most significant implants for treating bone injury, while the precise control of stem cell proliferation and differentiation within scaffold is still challenging. In this work,...

Cited by 4 publications

References 49 publications

Biomaterials for Regenerative Cranioplasty: Current State of Clinical Application and Future Challenges

Biomaterials for Regenerative Cranioplasty: Current State of Clinical Application and Future Challenges

Multifarious roles of metal elements in bone mineralization

The Biomimetic Electrical Stimulation System Inducing Osteogenic Differentiations of BMSCs

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