Multilayer amniotic membrane transplantation for bacterial keratitis with corneal perforation after hyperopic photorefractive keratectomy

Nubile, Mario; Carpineto, Paolo; Lanzini, Manuela; Ciancaglini, Marco; Zuppardi, Eduardo; Mastropasqua, Leonardo

doi:10.1016/j.jcrs.2007.04.040

Cited by 25 publications

(12 citation statements)

References 23 publications

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“…Furthermore, polymorphonuclear leukocytes cells (PMNs) migration and release of lysosome and oxidative compounds play an important role in the bacterial eradication. These responses may cause cornea tissue damage as well (7). Severe bacterial keratitis needs rapid and extended use of local antibiotic therapy.…”

Section: Key Pointmentioning

confidence: 99%

Antimicrobial effects of amniotic membrane on some bacterial strains

Heidarzadeh¹,

Ghasemian²,

Kalafi³

et al. 2018

Immunopathol Persa

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Section: Key Pointmentioning

confidence: 99%

Antimicrobial effects of amniotic membrane on some bacterial strains

Heidarzadeh¹,

Ghasemian²,

Kalafi³

et al. 2018

Immunopathol Persa

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“…Unlike P. aeruginosa , pneumococcal keratitis is not typically associated with contact lens use but rather with predisposing conditions such as ocular trauma or surgery [53,58,59,60,63,65,66,67,68,69]. …”

Section: Streptococcus Pneumoniaementioning

confidence: 99%

Proteomics in the Study of Bacterial Keratitis

et al. 2015

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Bacterial keratitis is a serious ocular infection that can cause severe visual loss if treatment is not initiated at an early stage. It is most commonly caused by Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumoniae, or Serratia species. Depending on the invading organism, bacterial keratitis can progress rapidly, leading to corneal destruction and potential blindness. Common risk factors for bacterial keratitis include contact lens wear, ocular trauma, ocular surface disease, ocular surgery, lid deformity, chronic use of topical steroids, contaminated ocular medications or solutions, and systemic immunosuppression. The pathogenesis of bacterial keratitis, which depends on the bacterium-host interaction and the virulence of the invading bacterium, is complicated and not completely understood. This review highlights some of the proteomic technologies that have been used to identify virulence factors and the host response to infections of bacterial keratitis in order to understand the disease process and develop improved methods of diagnosis and treatment. Although work in this field is not abundant, proteomic technologies have provided valuable information toward our current knowledge of bacterial keratitis. More studies using global proteomic approaches are warranted because it is an important tool to identify novel targets for intervention and prevention of corneal damage caused by these virulent microorganisms.

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“…Different types of ulcers result from different pathological processes and require different management approaches 2. Keratitis is usually caused by bacteria and fungi 3,4. Recently, fungal causation associated with soft contact lens use has become an increasing cause of concern 5.…”

Section: Introductionmentioning

confidence: 99%

“…Amniotic membrane transplantation has proved successful as an adjunctive method for corneal re-epithelization,3,8 but has not replaced keratoplasty, partly because of availability of donor tissue. Penetrating keratoplasty (PK) is a well established technique; however, long-recognized complications such as postoperative infection, corneal and macular edema, astigmatism, retinal detachment, and high rates of immune reactions and graft failure remain significant concerns 9–15…”

Section: Introductionmentioning

confidence: 99%

Outcome of penetrating keratoplasty in corneal ulcer: a single-center experience

Sedghipour

Sorkhabi²,

Shenasi³

et al. 2011

OPTH

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BackgroundCorneal ulcers often lead to scarring and astigmatism, and significant loss of vision is a common consequence.ObjectiveTo determine the rate of graft rejection, one of the most serious concerns with this procedure, and to evaluate the recovery of visual function in those patients for whom the operation was successful.MethodsWe describe a retrospective study of 33 corneal ulcer patients undergoing penetrating keratoplasty (PK) at the Tabriz Nikookari Eye Hospital.ResultsMean age of the patients was 44 ± 14 years. Most common risk factors for active keratitis were trauma, dry eye, and malnutrition. Culture-positive results included bacterial keratitis (n = 15) and fungal keratitis (n = 5). Perforation was a significant risk factor for therapeutic failure (P < 0.05). Age or gender had no statistically significant effects on the PK outcome (P > 0.05). Postoperative visual acuity had a significant association with preoperative visual acuity (P < 0.01). Graft rejection rate (27.2%) was similar to that reported in the literature.ConclusionAlthough lamellar keratoplasty has recently been established, there are practical reasons for continuing the use of PK in centers such as ours, with due attention to the requirement for topical immunosuppression to diminish the rate of graft rejection and antimicrobial treatment to prevent postoperative infection.

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Multilayer amniotic membrane transplantation for bacterial keratitis with corneal perforation after hyperopic photorefractive keratectomy

Cited by 25 publications

References 23 publications

Antimicrobial effects of amniotic membrane on some bacterial strains

Antimicrobial effects of amniotic membrane on some bacterial strains

Proteomics in the Study of Bacterial Keratitis

Outcome of penetrating keratoplasty in corneal ulcer: a single-center experience

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