Multiloculated renal cell carcinoma

Koga, Shigehiko; Yamasaki, Akihiko; Nishikido, Masaharu; Matsuo, Ryoichi; Matsuya, Fukuzo; Yushita, Yoshiaki; Kanetake, Hiroshi; Saito, Yutaka

doi:10.1007/bf02583984

Cited by 9 publications

(3 citation statements)

References 11 publications

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“…Judging from the fact that carcinomas existed in the acquired cysts, they might have originated from the cyst epithelia. It has been suggested that malignant transformation of a multilocular renal cyst may be another etiology of MCRCC (37). Hartman et al divided cystic renal cell carcinomas into four pathologic groups (4, 5) and reported that the cysts were formed secondarily, based on tumour degeneration.…”

Section: Discussionmentioning

confidence: 99%

Multilocular cystic renal cell carcinoma: a clinicopathological, immuno‐ and lectin histochemical study of nine cases

Imura

Ichikawa

Takeda

et al. 2004

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Multilocular cystic renal cell carcinoma (MCRCC) is an uncommon variant of renal neoplasm and its histogenesis is unclear. The aim of this study was to use immuno- and lectin histochemistry to delineate histochemical patterns which might indicate the histogenetic origin of MCRCC from a particular part or parts of the nephron. We present our experience with nine cases of MCRCC. Fifteen cases of renal cell carcinoma with cystic degeneration (RCC-CD) were selected for comparison with MCRCC. We carried out clinicopathological and immunohistochemical examinations of the MCRCC cases. Clinically, the prognosis of the patients was quite good, in that all nine patients are alive and without recurrence at the time of this report. The MCRCCs reacted strongly in a higher proportion of cases with the distal nephron markers, such as peanut agglutinin (PNA, 88.9%) and MUC1-core antibody (MUC1, 100%), but none reacted preferentially with proximal nephron markers such as vimentin, Leu M1 and Lotus tetragonolobus (LTA). The RCC-CD tumours reacted with vimentin (40%), Leu M1 (66.7%) and LTA (86.7%). Except for two cases, the RCC-CD tumours did not react with PNA or MUC1 core antibody. These results illustrate the different patterns of expression of MCRCC and RCC-CD and suggest that MCRCC originates from the distal nephron. Therefore, MCRCC should be differentiated from other types of renal cell carcinoma on the basis of the histogenesis of the tumour and the clinicopathological findings.

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Section: Discussionmentioning

confidence: 99%

Multilocular cystic renal cell carcinoma: a clinicopathological, immuno‐ and lectin histochemical study of nine cases

Imura

Ichikawa

Takeda

et al. 2004

APMIS

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“…Some renal cell carcinomas, although not common, show similar morphological appearance to this type of benign tumor. It is difficult to pre‐operatively differentiate multilocular cystic renal cell carcinomas from benign multilocular cystic tumors 5,6 . Therefore, small tumors of this type must be closely monitored, and surgical treatment should be considered if there are any signs of malignant changes 7 .…”

Section: Discussionmentioning

confidence: 99%

“…It is difficult to pre-operatively differentiate multilocular cystic renal cell carcinomas from benign multilocular cystic tumors. 5,6 Therefore, small tumors of this type must be closely monitored, and surgical treatment should be considered if there are any signs of malignant changes. 7 As multilocular cystic renal cell carcinomas, in general, show a good prognosis, 8 nephron-sparing surgery should be considered in the cases of small tumors.…”

Section: Case Reportmentioning

confidence: 99%

Spontaneously ruptured multilocular cystic nephroma

et al. 2002

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Multilocular cystic nephroma is a relatively rare benign tumor of the kidney. An adult case of spontaneously ruptured multilocular cystic nephroma was reported. A 33-year-old woman who presented with a right flank colic attack. The preoperative diagnosis was spontaneously ruptured renal tumor. A right nephrectomy was performed. A multilocular cystic lesion, 10 cm in diameter, was found in the removed specimen, which had a hematoma inside and direct tumor extension into the renal pelvis. On microscopic examination, the surface of loculi was covered by a layer of hobnail epithelium, and septa were composed of fibrous tissue with dilated vessels, lacking in normal renal components. There were no signs of malignancy. The lesion extending into the renal pelvis showed the same microscopic findings. The final diagnosis was multilocular cystic nephroma. Two respects, spontaneous rupture and tumor extension into the renal pelvis, were unique to the present case. There has been no report of spontaneously ruptured mutilocular cystic nephroma. The tumor extension into the renal pelvis, however, has been found in several reports. This growth pattern might be one of the characteristics of this benign renal tumor.

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